AZD3514

产品说明书

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Chemical Structure| 1240299-33-5 同义名 : -
CAS号 : 1240299-33-5
货号 : A806995
分子式 : C25H32F3N7O2
纯度 : 99%
分子量 : 519.56
MDL号 : MFCD25976791
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(202.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Androgen Receptor

    Androgen Receptor, Ki:2.2 μM
描述 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.62mL

1.92mL

0.96mL

19.25mL

3.85mL

1.92mL
参考文献

[1]Bradbury RH, Acton DG, et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8.

[2]Sarah A. Loddick, et al. Cancer Res, 2012, 72(8 Suppl), Abstract nr 3848.