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货号 产品名 纯度
A526563 现货 N-desmethyl Enzalutamide

N-desmethyl Enzalutamide 是 Enzalutamide 的活性代谢物,其主要和次要药效学作用与 Enzalutamide 本身相似,浓度与 Enzalutamide 在血浆中的浓度相当。

98%
A1228867 现货 ARCC-4

ARCC-4 是一种基于 PROTAC 技术的纳摩尔雄激素受体 (AR) 降解剂,D50 值为 5 nM。ARCC-4 是一种基于恩杂鲁胺的 von Hippel-Lindau (VHL) 招募的 AR PROTAC,能够有效降解与抗雄激素研究相关的 AR 突变体。

97%
A176397 现货 Bicalutamide/比卡鲁胺

Bicalutamide是一种口服活性、非甾体类雄激素受体(AR)拮抗剂,用于前列腺癌研究。

99%
A270395 现货 Enzalutamide/恩杂鲁胺

Enzalutamide(MDV3100) 是一种雄激素受体 (AR) 拮抗剂,在 LNCaP 前列腺细胞中的 IC50 为 36 nM。它还可以激活自噬

98%
A442284 现货 Dimethylcurcumin

Dimethylcurcumin(ASC-J9)是一种雄激素受体降解增强剂,有效抑制去势抵抗性前列腺癌细胞的增殖和侵袭。

98%+
A2328208 现货 Androgen receptor degrader-1

97%
A1167310 现货 Ralaniten

97%
A112189 现货 Triptophenolide/雷酚内酯

Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii.

99%+
A517338 现货 ORM-15341

ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.

98%
A201832 现货 EPI-001

EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator.

99%+
A789738 现货 ACP-105

ACP-105 is a potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.

97%
A721032 现货 Prochloraz/咪鲜胺

Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM).

98%
A208282 现货 Flutamide/氟他胺

Flutamide is a competitive non-steroidal antagonist of androgen receptor.

98%
A582855 现货 AR antagonist 1

98%+
A1176980 现货 DJ-V-159

99%+
A1249543 现货 VPC-13566

98%
A1339748 现货 SK33

99%+
A619453 现货 Ailanthone

Ailanthone, a natural product isolated and purified from the barks of Ailanthus altissima with high toxicity, has significant pre-emergence herbicide activity directly correlated to its concentration.

98%
A421534 现货 Protodioscin/原薯蓣皂苷

Protodioscin, a major steroidal saponin in dioscoreae rhizome, has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties. Protodioscin is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors.

97%
A1365651 现货 Apalutamide-d4

98% +98%atom%D
产品名 Androgen Receptor 其他靶点 纯度
Cyproterone acetate ++++

Androgen Receptor, IC50: 7.1 nM

98%
Apalutamide +++

Androgen Receptor, IC50: 16 nM

98%
AZD3514 +

Androgen Receptor, Ki: 2.2 μM

98%
Darolutamide ++++

Androgen receptor, Ki: 11 nM

98%
Flutamide +++

Androgen Receptor, Ki: 55 nM

98%
Galeterone ++

Androgen Receptor, IC50: 384 nM

98%
Enzalutamide +++

Androgen Receptor, IC50: 36 nM

98%
Megestrol 98%
Bicalutamide ++

Androgen Receptor, IC50: 0.16 μM

99%
EPI-001 +

Androgen Receptor, IC50: ~6 μM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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