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货号 产品名 纯度
A501481 DHODH-IN-17

97%
A278938 11β-HSD1-IN-12

97%
A786224 LY 345899

LY 345899, a Folate analog, is an inhibitor of methylene tetrahydrofolate dehydrogenase MTHFD1 (IC50 = 96 nM, Ki = 18 nM) and MTHFD2 (IC50 = 96 nM).

98%+
A324415 ADH-1

Exherin is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities and selectively and competitively binds to and blocks N-cadherin.

99%+
A932685 (R)-GNE-140

(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively.

99%+
A385200 2,2-Dihydroxy-1-phenylethan-1-one/苯乙二醛 水合物

Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase (ALDH), binding the arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.

95%
A879979 LDHA-IN-4

AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM.

99%+
A959606 Isovaleramide/3-甲基丁酰胺

Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii.

98%
A1361930 DHODH-IN-11

DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03.

99%+
A401180 2-Pyrazinecarboxylic acid/2-吡嗪羧酸

Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD.

98%
A983598 ASP-9521

ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3.

98%+
A1680546 LDCA

99%+
A122692 Teriflunomide/特立氟胺

Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.

99%+
A790334 TC HSD 21

TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1].

99%+
A101522 3-Methylpyrazole/3-甲基吡唑

3-Methylpyrazole is a nitrification inhibitor of nitrification in soil.

98%
A862176 Carbenoxolone disodium

Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

98%
A1209614 HQNO

HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.

97%
A143691 Mycophenolate Mofetil/吗替麦考酚酯

Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.

98+%
A207630 Brequinar Sodium/布列奎钠

Brequinar sodium is a potent inhibitor of the mitochondrial DHODH, a rate-limiting enzyme in the pyrimidine de novo nucleotide synthesis.

95%
A1483843 AG-636

AG-636 is a potent, reversible, selective and orally active DHODH inhibitor with IC50 value of 17nM.

99%+
产品名 Dehydrogenase 其他靶点 纯度
Trilostane 99+%
AGI-6780 +++

IDH2 R140Q mutant, IC50: 23 nM

99%+
Gimeracil 98%
AGI-5198 ++

R132C-IDH1, IC50: 0.16 μM

R132H-IDH1, IC50: 70 nM

99%+
SW033291 ++++

15-PGDH, IC50: 1.5 nM

15-PGDH, Ki: 0.1 nM

99%+
Mycophenolic acid 99+%
Fomepizole 98%
Leflunomide 98%
3-Nitropropanoic acid 99%+
Isovaleramide 98%
Mycophenolate Mofetil +++

Inosine monophosphate dehydrogenase II, IC50: 27 nM

Inosine monophosphate dehydrogenase I, IC50: 39 nM

98+%
MK-8245 ++++

SCD1 (mouse), IC50: 1 nM

SCD1 (rat), IC50: 3 nM

99%+
Vidofludimus ++

Human DHODH, IC50: 134 nM

99%+
Emodin 98%
Ivosidenib 98%
NCT-501 ++

ALDH1A1, IC50: 40 nM

98%
Gossypol 99%+
Devimistat 99%+
Disulfiram 97%
Enasidenib ++++

IDH2, IC50: 12 nM

98%
PluriSIn 1 99%+
ML390 +

DHODH, IC50: 0.56 μM

99%+
Teriflunomide 99%+
Daidzin +++

ALDH-Ⅰ, Ki: 20 nM

98+%
18β-Glycyrrhetinic acid 99%
RRx-001 95%
NCT-503 +

PHGDH, IC50: 2.5 μM

99%+
Vorasidenib 99%+
Ammonium Glycyrrhizinate(x:1) 98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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