Trilostane | 曲洛斯坦 | Win 24540 | 3-β-Hydroxysteroid Dehydrogenase Inhibitor

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Trilostane/曲洛司坦 {[allProObj[0].p_purity_real_show]}

货号：A378777 同义名： 曲洛斯坦 / Win 24540; Desopan

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome.

Trilostane/曲洛司坦化学结构
CAS号：13647-35-3

Trilostane/曲洛司坦 3D分子结构
CAS号：13647-35-3

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Trilostane/曲洛司坦纯度/质量文件产品仅供科研

货号：A378777 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

脱氢酶亚型比较

产品名称	Dehydrogenase ↓ ↑	纯度
Trilostane	✔	99+%
AGI-6780	+++ IDH2 R140Q mutant, IC50: 23 nM	99%+
Gimeracil	✔	98%
AGI-5198	++ R132C-IDH1, IC50: 0.16 μM R132H-IDH1, IC50: 70 nM	99%+
SW033291	++++ 15-PGDH, IC50: 1.5 nM 15-PGDH, Ki: 0.1 nM	99%+
Mycophenolic acid	✔	99+%
Fomepizole	✔	98%
Leflunomide	✔	98%
3-Nitropropanoic acid	✔	99%+
Isovaleramide	✔	99%
Mycophenolate Mofetil	+++ Inosine monophosphate dehydrogenase II, IC50: 27 nM Inosine monophosphate dehydrogenase I, IC50: 39 nM	98%
MK-8245	++++ SCD1 (rat), IC50: 3 nM SCD1 (mouse), IC50: 1 nM	99%+
Vidofludimus	++ Human DHODH, IC50: 134 nM	99%+
Emodin	✔	98%
Ivosidenib	✔	98%
NCT-501	++ ALDH1A1, IC50: 40 nM	98%
Gossypol	✔	99%+
Devimistat	✔	98%
Disulfiram	✔	98%+
Enasidenib	++++ IDH2, IC50: 12 nM	98%
PluriSIn 1	✔	99%+
ML390	+ DHODH, IC50: 0.56 μM	99%+
Teriflunomide	✔	99%+
Daidzin	+++ ALDH-Ⅰ, Ki: 20 nM	98+%
18β-Glycyrrhetinic acid	✔	99%
RRx-001	✔	95%
NCT-503	+ PHGDH, IC50: 2.5 μM	99%+
Vorasidenib	✔	99%+
Ammonium Glycyrrhizinate(x:1)	✔	98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Trilostane/曲洛司坦生物活性

靶点

Dehydrogenase

描述

Trilostane is a recognized treatment for canine pituitary-dependent hyperadrenocorticism (PDH); The median survival time for animals treated with trilostane was 353 days (95% confidence interval [CI] 95-528 days)^[3]. During trilostane therapy, urinary catecholamines and their metabolites did not decrease significantly. However, dogs with low post-ACTH cortisol concentrations during trilostane therapy had less increased epinephrine, norepinephrine and normetanephrine, creatinine ratios compared to healthy dogs^[4]. In a substantial number of dogs treated with trilostane, the two prepill cortisol concentrations differed. Part of this difference might be ascribable to stressful events during test performance^[5].

Trilostane/曲洛司坦临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01615211	Medical Abortion, Complete or ... 展开 >>Unspecified, Without Complication 收起 <<	Phase 2	Terminated(No access to study ... 展开 >>drug Trilostan. Company closed down) 收起 <<	-	Sweden ... 展开 >> Karolinska University Hospital Stockholm, Sweden, 17177 收起 <<
NCT00181597	Prostate Cancer ... 展开 >> Prostate Adenocarcinoma 收起 <<	Phase 2	Completed	-	United States, Massachusetts ... 展开 >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 收起 <<

Trilostane/曲洛司坦参考文献

[1]Feldman EC, Kass PH. Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. J Vet Intern Med. 2012 Jul-Aug;26(4):1078-80.

[2]Helm JR, McLauchlan G, et al. A comparison of factors that influence survival in dogs with adrenal-dependent hyperadrenocorticism treated with mitotane or trilostane. J Vet Intern Med. 2011 Mar-Apr;25(2):251-60.

[3]Helm JR, McLauchlan G, Boden LA, Frowde PE, Collings AJ, Tebb AJ, Elwood CM, Herrtage ME, Parkin TD, Ramsey IK. A comparison of factors that influence survival in dogs with adrenal-dependent hyperadrenocorticism treated with mitotane or trilostane. J Vet Intern Med. 2011 Mar-Apr;25(2):251-60

[4]Sieber-Ruckstuhl N, Salesov E, Quante S, Riond B, Rentsch K, Hofmann-Lehmann R, Reusch C, Boretti F. Effects of Trilostane on urinary Catecholamines and their metabolites in dogs with Hypercortisolism. BMC Vet Res. 2017 Sep 4;13(1):279

[5]Boretti F, Musella C, Burkhardt W, Kuemmerle-Fraune C, Riond B, Reusch C, Sieber-Ruckstuhl N. Comparison of two prepill cortisol concentrations in dogs with hypercortisolism treated with trilostane. BMC Vet Res. 2018 Dec 27;14(1):417

Trilostane/曲洛司坦实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.36mL

6.07mL

3.04mL

Trilostane/曲洛司坦技术信息

CAS号	13647-35-3
分子式	C₂₀H₂₇NO₃
分子量	329.43
SMILES Code	C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])CC[C@]45[C@](O5)([H])C(O)=C(C#N)C[C@]4(C)[C@@]3([H])CC2
MDL No.	MFCD00199295

别名	曲洛斯坦 ;Win 24540; Desopan; Modrenal.; Modrastane. Desopan; D-01180; DB01108; Vetoryl; Modrefen
运输	蓝冰
InChI Key	KVJXBPDAXMEYOA-CXANFOAXSA-N
Pubchem ID	656583

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, 2-8°C

溶解方案

细胞实验：

DMSO: 55 mg/mL(166.95 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

Trilostane/曲洛司坦 {[allProObj[0].p_purity_real_show]}

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Trilostane/曲洛司坦参考文献

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Trilostane/曲洛司坦纯度/质量文件产品仅供科研

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Trilostane/曲洛司坦生物活性

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Trilostane/曲洛司坦参考文献

Trilostane/曲洛司坦实验方案

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