3-Nitropropionic acid is a natural product isolated and purified from Indigofera spicata
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HazMat fee for 500 gram (Estimated)
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3-Nitropropionic acid is a natural product isolated and purified from Indigofera spicata
3-Nitropropanoic acid/3-硝基丙酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Albino Wistar female rats
Huntington's disease model
Intraperitoneal injection
10 mg/kg
Twice daily for 4 days
To evaluate the protective effects of tBHQ pretreatment against 3-NP-induced neurotoxicity, results showed tBHQ pretreatment improved motor activity and reduced oxidative damage in old rats
Redox Biol. 2017 Aug;12:610-624
C57/BL6 mice
Mitochondrial dysfunction model
Intraperitoneal injection
15 mg/kg
Once daily for 5 days
To evaluate the effect of 3-NP on the mRNA expression of neurotrophins and their receptors in the striatum. Results showed that 3-NP treatment differentially affected the mRNA expression of neurotrophins and their receptors, and 18S rRNA was a reliable internal control gene.
Neurosci Bull. 2012 Oct;28(5):517-31
Wistar albino rats
3-Nitropropionic acid-induced Huntington's disease model
Intraperitoneal injection
10 mg/kg
Once daily for 14 days
To evaluate the effects of 3-nitropropionic acid on behavioral, motor, and cognitive functions in rats, and the neuroprotective effects of Vildagliptin. Results showed that 3-nitropropionic acid significantly impaired motor coordination and cognitive functions, which were ameliorated by Vildagliptin.
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