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脱氢酶
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DS18561882
DS18561882
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货号：A1339726
DS18561882 是一种高效、选择性强的亚甲基四氢叶酸脱氢酶 2 (MTHFD2) 抑制剂，IC50 值为 0.0063 μM，抑制 MTHFD1 的 IC50 值为 0.57 μM，具有良好的口服药代动力学特性。
DS18561882 化学结构
CAS号：2227149-22-4
DS18561882 3D分子结构
CAS号：2227149-22-4
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现货 |
1周
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DS18561882 纯度/质量文件 产品仅供科研
货号：A1339726
标准纯度：
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DS18561882 质控信息
| Trilostane |
✔
|
|
99+% |
| AGI-6780 |
+++
IDH2 R140Q mutant, IC50: 23 nM
|
|
99%+ |
| Gimeracil |
✔
|
|
98% |
| AGI-5198 |
++
R132C-IDH1, IC50: 0.16 μM
R132H-IDH1, IC50: 70 nM
|
|
99%+ |
| SW033291 |
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
|
|
99%+ |
| Mycophenolic acid |
✔
|
|
99+% |
| Fomepizole |
✔
|
|
98% |
| Leflunomide |
✔
|
|
98% |
| 3-Nitropropanoic acid |
✔
|
|
99%+ |
| Isovaleramide |
✔
|
|
99% |
| Mycophenolate Mofetil |
+++
Inosine monophosphate dehydrogenase II, IC50: 27 nM
Inosine monophosphate dehydrogenase I, IC50: 39 nM
|
|
98% |
| MK-8245 |
++++
SCD1 (mouse), IC50: 1 nM
SCD1 (rat), IC50: 3 nM
|
|
99%+ |
| Vidofludimus |
++
Human DHODH, IC50: 134 nM
|
|
99%+ |
| Emodin |
✔
|
|
98% |
| Ivosidenib |
✔
|
|
98% |
| NCT-501 |
++
|
|
98% |
| Gossypol |
✔
|
|
99%+ |
| Devimistat |
✔
|
|
98% |
| Disulfiram |
✔
|
|
98%+ |
| Enasidenib |
++++
|
|
98% |
| PluriSIn 1 |
✔
|
|
99%+ |
| ML390 |
+
|
|
99%+ |
| Teriflunomide |
✔
|
|
99%+ |
| Daidzin |
+++
|
|
98+% |
| 18β-Glycyrrhetinic acid |
✔
|
|
99% |
| RRx-001 |
✔
|
|
95% |
| NCT-503 |
+
|
|
99%+ |
| Vorasidenib |
✔
|
|
99%+ |
| Ammonium Glycyrrhizinate(x:1) |
✔
|
|
98+% |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
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DS18561882 细胞实验
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Cell Line
|
Concentration |
Treated Time |
Description |
References |
| C4-2B cells |
50μM |
|
DS18561882 significantly inhibits CRPC cell proliferation |
J Exp Clin Cancer Res. 2022 Apr 5;41(1):125 |
| LNCaP cells |
50μM |
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DS18561882 significantly inhibits CRPC cell proliferation |
J Exp Clin Cancer Res. 2022 Apr 5;41(1):125 |
| HCC78 |
20 µM |
48 hours |
Inhibition of MTHFD2 significantly reduced the viability of HCC78 cells. |
Metabolites. 2022 Jul 15;12(7):652 |
| H1993 |
20 µM |
48 hours |
Inhibition of MTHFD2 significantly reduced the viability of H1993 cells. |
Metabolites. 2022 Jul 15;12(7):652 |
| H23 |
20 µM |
48 hours |
Inhibition of MTHFD2 significantly reduced the viability of H23 cells. |
Metabolites. 2022 Jul 15;12(7):652 |
| HCC44 |
20 µM |
48 hours |
Inhibition of MTHFD2 significantly reduced the viability of HCC44 cells. |
Metabolites. 2022 Jul 15;12(7):652 |
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DS18561882 动物实验
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Species
|
Animal Model
|
Administration |
Dosage |
Frequency |
Description |
References |
| Nude mice |
Subcutaneous xenograft model |
Oral |
100mg/kg |
Once daily |
DS18561882 significantly inhibits CRPC tumor growth |
J Exp Clin Cancer Res. 2022 Apr 5;41(1):125 |
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DS18561882 实验方案
| 计算器 |
|
| 存储液制备 |
 |
1mg |
5mg |
10mg |
|
1 mM
5 mM
10 mM
|
1.64mL
0.33mL
0.16mL
|
8.22mL
1.64mL
0.82mL
|
16.43mL
3.29mL
1.64mL
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DS18561882 技术信息
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