BMY 7378是一种5-HT1A部分激动剂和高亲和力α1D肾上腺素受体拮抗剂，对大鼠α1D、α1A和仓鼠α1B受体的Ki值分别为2、800和600 nM。

Nebivolol hydrochloride是Nebivolol的盐酸盐形式。Nebivolol作为第三代高选择性β₁受体拮抗剂（β₁ IC₅₀=0.8 nM，β₁/β₂选择性比=293:1），兼具β₃受体激动与eNOS激活特性，通过多通路协同发挥心血管保护作用。Nebivolol通过激动β₃受体，激活Gi蛋白和PI3K/Akt通路，促进eNOS磷酸化，发挥血管舒张作用；通过抑制NADPH氧化酶，降低ROS生成，发挥抗氧化作用。

Propranolol HCl是一种非选择性β1/β2受体阻滞剂，阻断cAMP依赖的钙通道激活，降低心输出量；抑制肾素释放，阻断突触前β2受体减少去甲肾上腺素释放。用于高血压、甲状腺危象及焦虑相关震颤。

Betaxolol HCl is a competitive and cardioselective β1 adrenergic receptor antagonist, used to treat hypertension, arrhythmias, coronary heart disease, glaucoma, and reduce non-fatal cardiac events in patients with heart failure with elimination half-life of 14–22 hours.

ICI 118551 HCl is a selective and inverse β2 adrenergic receptor antagonist with Ki values of 1.2, 120 and 257nM for β2, β1 and β3 receptors, respectively.

Bisoprolol是一种高选择性β₁-肾上腺素受体拮抗剂，对人β₁受体IC₅₀ = 3.9 nM（竞争性结合实验），β₁/β₂选择性比达 75:1。Bisoprolol通过抑制 cAMP/PKA通路，阻断儿茶酚胺诱导的cAMP积累；激活 eNOS/NO通路增强内皮依赖性血管舒张；抑制 RhoA/ROCK通路降低血管平滑肌钙敏感性。

Metoprolol是一种高选择性β₁-肾上腺素受体拮抗剂，通过靶向心肌与血管系统发挥保护作用。Metoprolol通过抑制 cAMP/PKA通路，减少钙离子内流；激活 AMPK/eNOS通路，改善内皮功能；抑制 NOX4/ROS通路，减轻氧化损伤。

Sotalol Hydrochloride是一种非选择性β受体阻滞剂兼III类抗心律失常药。Sotalol hydrochloride 阻断 β受体和钾KCNH2 通道，具有抗抗癫痫作用。

Acebutolol HCl is a cardioselective β1 adrenergic antagonist with little effect on the bronchial receptors.

Carteolol HCl is a non-selective β-adrenergic receptor blocker and a serotonin 5-HT1A and 5-HT1B receptor antagonist, used as an agent for anti-arrhythmia, anti-angina, antihypertensive and antiglaucoma.

Esmolol HCl is a short and rapid-acting β adrenergic antagonist belonging to the class II anti-arrhythmic drugs with elimination half-life‎ of ‎9 minutes.

Betaxolol is a competitive and cardioselective β1 adrenergic receptor antagonist, used to treat hypertension, arrhythmias, coronary heart disease, glaucoma, and reduce non-fatal cardiac events in patients with heart failure with elimination half-life of 14–22 hours.