Quercetin hydrate | Quercetin (hydrate) | Flavonoid Antioxidant

Quercetin hydrate/槲皮素水合物 {[allProObj[0].p_purity_real_show]}

货号：A1257621 同义名： Quercetin (hydrate)

Quercetin hydrate 是一种天然黄酮类化合物，刺激重组 SIRT1 并抑制 PI3K，对 PI3K γ、PI3K δ 和 PI3K β 的 IC50 值分别为 2.4 μM、3.0 μM 和 5.4 μM。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Quercetin hydrate/槲皮素水合物化学结构
CAS号：849061-97-8

Quercetin hydrate/槲皮素水合物 3D分子结构
CAS号：849061-97-8

规格	价格	会员价	库存	数量
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PI3K 亚型比较

自噬亚型比较

产品名称	C2β ↓ ↑	p110α ↓ ↑	p110β ↓ ↑	p110γ ↓ ↑	p110δ ↓ ↑	PI3K ↓ ↑	Vps34 ↓ ↑	其他靶点	纯度
A66	+ C2β, IC50: 462 nM	++ p110α, IC50: 32 nM							99%+
Taselisib	+ C2β, IC50: 292 nM	++++ PI3Kα, Ki: 0.29 nM	+++ PI3Kβ, Ki: 9.1 nM	++++ PI3Kγ, Ki: 0.97 nM	++++ PI3Kδ, Ki: 0.12 nM		+ hVps34, IC50: 374 nM		99%+
Gedatolisib		++++ PI3Kα, IC50: 0.4 nM		+++ PI3Kγ, IC50: 5.4 nM				mTOR	99%
HS-173		++++ PI3Kα , IC50: 0.8 nM							99%+
Serabelisib		+++ PI3Kα, IC50: 21 nM							99%+
GNE-477		++++ PI3Kα, IC50: 4 nM						mTOR	99%
YM-201636		+ p110α, IC50: 3.3 μM						PIKfyve	98%
AS-252424		+ PI3Kα, IC50: 935 nM		++ PI3Kγ, IC50: 33 nM					99%
Alpelisib		+++ PI3Kα, IC50: 5 nM							99%+
AS-604850		+ PI3Kα, IC50: 4.5 μM		+ PI3Kγ, IC50: 0.25 μM					99%
SF2523		++ PI3Kα, IC50: 34 nM		++ PI3Kγ, IC50: 158 nM				DNA-PK,mTOR	99%+
Inavolisib		++++ PI3K alpha, IC50: 0.038 nM							99%+
Bimiralisib		++++ PI3Kα, Kd: 1.5 nM	+++ PI3Kβ, Kd: 11 nM	++ PI3Kγ, Kd: 25 nM	++ PI3Kδ, Kd: 25 nM			mTOR	99%+
GSK1059615		++++ PI3Kα, IC50: 0.4 nM	++++ PI3Kβ, IC50: 0.6 nM	+++ PI3Kγ, IC50: 5 nM	++++ PI3Kδ, IC50: 2 nM			mTOR	98%
GSK2636771			✔						99%
Fimepinostat		+++ PI3Kα, IC50: 19 nM	++ PI3Kβ, IC50: 54 nM		++ PI3Kδ, IC50: 39 nM				99%+
VS-5584		++++ PI3Kα, IC50: 2.6 nM	+++ PI3Kβ, IC50: 21 nM	++++ PI3Kγ, IC50: 3.0 nM	++++ PI3Kδ, IC50: 2.7 nM			mTOR	98%
Dactolisib		++++ p110α1, IC50: 4 nM	++ p110β, IC50: 75 nM	+++ p110γ, IC50: 5 nM	+++ p110δ, IC50: 7 nM				98+%
PI-103		++++ p110α, IC50: 2 nM	++++ p110β, IC50: 3 nM	+++ p110γ, IC50: 15 nM	++++ p110δ, IC50: 3 nM			DNA-PK,mTOR	99%+
PI-3065			+ p110β, IC50: 1078 nM		+++ p110δ, IC50: 15 nM				99%+
Voxtalisib		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			DNA-PK,mTOR	99%+
AZD-8835		+++ PI3Kα, IC50: 6.2 nM	+ PI3Kβ, IC50: 431 nM	++ PI3Kγ, IC50: 90 nM	+++ PI3Kδ, IC50: 5.7 nM				99%
Pilaralisib analogue		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 36 nM	+++ PI3Kγ, IC50: 23 nM	++ PI3Kδ, IC50: 36 nM				99%+
ZSTK474		+++ PI3Kα, IC50: 16 nM	++ PI3Kβ, IC50: 44 nM	++ PI3Kγ, IC50: 49 nM	+++ PI3Kδ, IC50: 4.6 nM	++ PI3K, IC50: 37 nM			98%
AS-605240		++ PI3Kα, IC50: 60 nM	+ PI3Kβ, IC50: 270 nM	+++ PI3Kγ, IC50: 8 nM	+ PI3Kδ, IC50: 300 nM				98%
TGX-221			+++ p110β, IC50: 5 nM		++ p110δ, IC50: 0.1 μM				99%+
PF-04691502		++++ PI3Kα, Ki: 1.8 nM	++++ PI3Kβ, Ki: 2.1 nM	++++ PI3Kγ, Ki: 1.9 nM	++++ PI3Kδ, Ki: 1.6 nM			mTOR	98+%
GDC-0084		++++ PI3Kα, Ki app: 2 nM	++ PI3Kβ, Ki app: 46 nM	+++ PI3Kγ, Ki app: 10 nM	++++ PI3Kδ, Ki app: 3 nM			mTOR	99%+
Buparlisib		++ p110α, IC50: 52 nM	+ p110β, IC50: 166 nM	+ p110γ, IC50: 262 nM	++ p110δ, IC50: 116 nM		+ Vps34, IC50: 2.4 μM	mTOR	98%
LY294002		+ p110α, IC50: 0.5 μM	+ p110β, IC50: 0.97 μM		+ p110δ, IC50: 0.57 μM			DNA-PK	99%+
AZD 6482		+ PI3Kα, IC50: 870 nM	+++ PI3Kβ, IC50: 10 nM		++ PI3Kδ, IC50: 80 nM			DNA-PK	99%+
Pictilisib		++++ p110α, IC50: 3 nM	++ p110β, IC50: 33 nM	++ p110γ, IC50: 75 nM	++++ p110δ, IC50: 3 nM			mTOR	99%+
PKI-402		++++ PI3Kα, IC50: 2 nM	+++ PI3Kβ, IC50: 7 nM	+++ PI3Kγ, IC50: 16 nM	+++ PI3Kδ, IC50: 14 nM			mTOR	98%
Copanlisib		++++ PI3Kα, IC50: 0.5 nM	++++ PI3Kβ, IC50: 3.7 nM	+++ PI3Kγ, IC50: 6.4 nM	++++ PI3Kδ, IC50: 0.7 nM				99%+
Omipalisib		++++ p110α, Ki: 0.019 nM	++++ p110β, Ki: 0.13 nM	++++ p110γ, Ki: 0.06 nM	++++ p110δ, Ki: 0.024 nM				99%+
Izorlisib		+++ PI3Kα, IC50: 14 nM	++ PI3Kβ, IC50: 0.12 μM	++ PI3Kγ, IC50: 36 nM	+ PI3Kδ, IC50: 0.50 μM				99%+
AZD8186		++ PI3Kα, IC50: 35 nM	++++ PI3Kβ, IC50: 4 nM		+++ PI3Kδ, IC50: 12 nM				99%
KU-0060648		++++ PI3Kα, IC50: 4 nM	++++ PI3Kβ, IC50: 0.5 nM	+ PI3Kγ, IC50: 0.59 μM	++++ PI3Kδ, IC50: 0.1 nM			DNA-PK	98%
Apitolisib		+++ p110α, IC50: 5 nM	++ p110β, IC50: 27 nM	+++ p110γ, IC50: 14 nM	+++ p110δ, IC50: 7 nM			mTOR	98%+
CZC24832			+ PI3Kβ, IC50: 1.1 μM	++ PI3Kγ, IC50: 27 nM					98+%
BGT226 maleate		++++ PI3Kα, IC50: 4 nM	++ PI3Kβ, IC50: 63 nM	++ PI3Kγ, IC50: 38 nM				mTOR	99%+
TG 100713		++ PI3Kα, IC50: 165 nM	+ PI3Kβ, IC50: 215 nM	++ PI3Kγ, IC50: 50 nM	+++ PI3Kδ, IC50: 24 nM				98%+
PI3K-IN-1		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			DNA-PK,mTOR	98+%
TG100-115		+ PI3Kα, IC50: 1.3 μM	+ PI3Kβ, IC50: 1.2 μM	++ PI3Kγ, IC50: 83 nM	+ PI3Kδ, IC50: 235 nM				98%
PIK-90		+++ PI3Kα, IC50: 11 nM	+ PI3Kβ, IC50: 350 nM	+++ PI3Kγ, IC50: 18 nM	++ PI3Kδ, IC50: 58 nM				99%+
PIK-294			+ p110β, IC50: 490 nM	++ p110γ, IC50: 160 nM	+++ p110δ, IC50: 10 nM				99%+
Duvelisib			++++ PI3Kβ, Ki: 1564 pM	++ PI3Kγ, Ki: 243 pM	++++ PI3Kδ, Ki: 23 pM				99%+
GDC-0326		++++ PI3Kα, Ki: 0.2 nM	++ PI3Kβ, Ki: 26.6 nM	+++ PI3Kγ, Ki: 10.2 nM	++++ PI3Kδ, Ki: 4 nM				98%
Quercetin Dihydrate			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM				95%
Quercetin			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM			Sirtuin,Src,PKC	95%
Leniolisib		+ PI3Kα, IC50: 0.244 μM	+ PI3Kβ, IC50: 0.424 μM	+ PI3Kγ, IC50: 2.23 μM	+++ PI3Kδ, IC50: 0.011 μM			DNA-PK	99%+
PIK-108			✔						99%
Eganelisib				+++ PI3Kγ, IC50: 16 nM					99%+
CAY10505				✔					99%
IPI-3063					++++ p110δ, IC50: 2.5 nM				99%
Nemiralisib					++++ PI3Kδ, pKi: 9.9				99%+
PF-4989216		++++ p110α, IC50: 2 nM		++ p110γ, IC50: 65 nM	++++ p110δ, IC50: 1 nM				99%+
PIK-75 HCl		+++ p110α, IC50: 5.8 nM		++ p110γ, IC50: 76 nM	+ p110δ, IC50: 0.51 μM			DNA-PK	99%+
Tenalisib				++ PI3Kγ, IC50: 33.2 nM	++ PI3Kδ, IC50: 24.5 nM				98%
Acalisib					+++ p110δ, IC50: 14 nM				99%+
Umbralisib					+++ PI3Kδ, IC50: 22.2 nM				99%+
AMG319				+ PI3Kγ, IC50: 850 nM	+++ PI3Kδ, IC50: 18 nM				99%
IC-87114				+ PI3Kγ, IC50: 29 μM	+ PI3Kδ, IC50: 0.5 μM				99%+
Idelalisib				++ p110γ, IC50: 89 nM	++++ p110δ, IC50: 2.5 nM				98%
PIK-293				+ p110γ, IC50: 10 μM	+ p110δ, IC50: 0.24 μM				99%+
Vps34-PIK-III					+ PI3Kδ, IC50: 1.2μM		+++ Vps34, IC50: 0.018μM		99%+
GSK2292767					✔				98%
Seletalisib				+ PI3Kγ, IC50: 282 nM	+++ PI3Kδ, IC50: 12 nM				99%+
P110δ-IN-1					++++ P110δ, IC50: 0.6 nM				99%
PI3Kδ-IN-5					++++ PI3Kδ, IC50: 0.9 nM				99%
SRX3207		+ PI3K alpha, IC50: 244 nM		+ PI3K gamma, IC50: 9790 nM	+ PI3K delta, IC50: 388 nM			Syk	98%
Parsaclisib HCl					++++ PI3Kδ, IC50: 1 nM				98%
IHMT-PI3Kδ-372					+++ PI3Kδ, IC50: 14 nM				98%
Trigonelline						✔		Akt	99%+
Wortmannin						++++ PI3K, IC50: 3 nM		DNA-PK,MLCK	99%+
Samotolisib						✔		DNA-PK	99%+
GNE-317						✔			99%+
Oroxin B						✔		Akt,PTEN	99%+
NU 7026						+ PI3K, IC50: 13 μM		DNA-PK	98+%
Deguelin						✔		Akt	99%+
Ailanthone						✔		Akt,CDK,ATM/ATR	98%
Resibufogenin						✔		ROS	98%
KU-57788						+ PI3K, IC50: 5 μM		DNA-PK,mTOR	99%+
Cinobufagine						✔		Akt	99%
α-Linolenic acid						✔			97% (GC)
MTX-211						✔		EGFR	98%
PI3K/mTOR Inhibitor-2						++++ PI3K, IC50: 3.4 nM		mTOR	99%+
SPP-86						✔			99%+
(E)-Akt inhibitor-IV						✔			98%
Vps34-IN-1							++ Vps34, IC50: 25 nM		98%
SAR405							++++ Vps34, IC50: 1.2 nM		98+%
3-Methyladenine				+ PI3Kγ, IC50: 60 μM			+ Vps34, IC50: 25 μM	Autophagy	98%
Vps34-IN-4							+++ VPS34, IC50: 15 nM		98%+
Autophinib							+++ Vps34, IC50: 19 nM	Autophagy	99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK1, IC50: 108 nM ULK2, IC50: 711 nM		95%
Hydroxychloroquine sulfate	✔		99%
Valproic acid sodium	✔	HDAC	97%
PFK-015	++ PFKFB3, IC50: 207 nM		99%+
MRT68921 HCl	++++ ULK1, IC50: 2.9 nM ULK2, IC50: 1.1 nM		99%+
ROC-325	✔		99%+
Autophinib	+++ Autophagy, IC50: 40 nM		99%
Lys05	✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Quercetin hydrate/槲皮素水合物生物活性

描述

Quercetin hydrate, known for its potent bioactivities as a natural flavonoid, functions as a significant enhancer of recombinant SIRT1 and as a PI3K inhibitor, displaying IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM for PI3K γ, δ, and β isoforms, respectively^[1].

体内研究

Additionally, when combined with 2-Methoxyestradiol at a dosage of 75 mg/kg, it significantly curtails tumor growth in xenograft models of human prostate cancer LNCaP and PC-3 cells, highlighting its potential in cancer therapy^[3].

体外研究

Quercetin hydrate's application extends beyond supplements, beverages, or foods, owing to its anti-inflammatory and antioxidant properties. These properties make quercetin hydrate an attractive subject for research into its potential health benefits. Specifically, it robustly targets PI3K and Src kinases, moderately affects Akt1/2, and has a lesser impact on PKC, p38, and ERK1/2^[1].

Quercetin hydrate's ability to inhibit TNF-induced LDH release, reduce EC-dependent neutrophil adhesion to BPAECs, and diminish BPAEC DNA synthesis and proliferation underscores its therapeutic potential^[2].

Quercetin hydrate/槲皮素水合物细胞实验

Cell Line Human periodontal ligament cells (hPDLCs) HK-2 human renal tubular epithelial cells HEK293 cells ERα/ERβ reporter cells C2C12 skeletal muscle cells AMJ2-C11 cells MIN-6 cells MIN-6 cells	Concentration	Treated Time	Description	References
Human periodontal ligament cells (hPDLCs)	5 μM	24 h	Quercetin alleviated oxidative damage and enhanced the antioxidant capacity of hPDLCs by activating the NRF2 signaling pathway, and protected their osteogenic ability.	Drug Des Devel Ther. 2021 Aug 12;15:3509-3522.
HK-2 human renal tubular epithelial cells	5 μM	48 h	Quercetin significantly reduced the accumulation of fibrosis- and inflammation-related proteins induced by IL-33 and improved renal cell pyroptosis via the IL33/ST2 pathway.	Antioxidants (Basel). 2022 Nov 13;11(11):2238.
HEK293 cells	10 μM		Quercetin inhibited hP2X3 and hP2X2 with IC50 values of 4.72 ± 0.35 and 17.1 ± 0.9 μM, respectively, indicating its relative selectivity for P2X3 receptors.	Nat Commun. 2023 Sep 20;14(1):5844.
ERα/ERβ reporter cells	0.023–50 µg/mL	24 h	To evaluate the activation of ERα and ERβ by Quercetin, results showed that Quercetin had a stronger activation effect on ERβ than on ERα.	Int J Mol Sci. 2021 Jan 21;22(3):1032.
C2C12 skeletal muscle cells	25, 50, 75, 100 µM	24 h	Quercetin significantly increased the viability of dexamethasone-treated C2C12 cells and exerted antiapoptotic effects by regulating mitochondrial membrane potential (ΔΨm) and reducing oxidative species.	Molecules. 2020 Jul 17;25(14):3267.
AMJ2-C11 cells	20 μM	1 h	Quercetin significantly suppressed LPS-induced production of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, and this suppression was attenuated by the HO-1 inhibitor SnPP.	Respir Res. 2014 Nov 21;15(1):150.
MIN-6 cells	10 μM	1 h	To evaluate the effect of quercetin on insulin secretion, results showed that quercetin significantly increased insulin secretion	Drug Des Devel Ther. 2018 Apr 23;12:955-966.
MIN-6 cells	10 μM	24 h	To evaluate the protective effect of quercetin on palmitic acid-induced cell apoptosis, results showed that quercetin significantly improved cell viability	Drug Des Devel Ther. 2018 Apr 23;12:955-966.

Cell Line

Human periodontal ligament cells (hPDLCs) HK-2 human renal tubular epithelial cells HEK293 cells ERα/ERβ reporter cells C2C12 skeletal muscle cells AMJ2-C11 cells MIN-6 cells MIN-6 cells

Concentration

Treated Time

Description

References

Human periodontal ligament cells (hPDLCs)

5 μM

24 h

Quercetin alleviated oxidative damage and enhanced the antioxidant capacity of hPDLCs by activating the NRF2 signaling pathway, and protected their osteogenic ability.

Drug Des Devel Ther. 2021 Aug 12;15:3509-3522.

HK-2 human renal tubular epithelial cells

5 μM

48 h

Quercetin significantly reduced the accumulation of fibrosis- and inflammation-related proteins induced by IL-33 and improved renal cell pyroptosis via the IL33/ST2 pathway.

Antioxidants (Basel). 2022 Nov 13;11(11):2238.

HEK293 cells

10 μM

Quercetin inhibited hP2X3 and hP2X2 with IC50 values of 4.72 ± 0.35 and 17.1 ± 0.9 μM, respectively, indicating its relative selectivity for P2X3 receptors.

Nat Commun. 2023 Sep 20;14(1):5844.

ERα/ERβ reporter cells

0.023–50 µg/mL

24 h

To evaluate the activation of ERα and ERβ by Quercetin, results showed that Quercetin had a stronger activation effect on ERβ than on ERα.

Int J Mol Sci. 2021 Jan 21;22(3):1032.

C2C12 skeletal muscle cells

25, 50, 75, 100 µM

24 h

Quercetin significantly increased the viability of dexamethasone-treated C2C12 cells and exerted antiapoptotic effects by regulating mitochondrial membrane potential (ΔΨm) and reducing oxidative species.

Molecules. 2020 Jul 17;25(14):3267.

AMJ2-C11 cells

20 μM

1 h

Quercetin significantly suppressed LPS-induced production of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, and this suppression was attenuated by the HO-1 inhibitor SnPP.

Respir Res. 2014 Nov 21;15(1):150.

MIN-6 cells

10 μM

1 h

To evaluate the effect of quercetin on insulin secretion, results showed that quercetin significantly increased insulin secretion

Drug Des Devel Ther. 2018 Apr 23;12:955-966.

MIN-6 cells

10 μM

24 h

To evaluate the protective effect of quercetin on palmitic acid-induced cell apoptosis, results showed that quercetin significantly improved cell viability

Drug Des Devel Ther. 2018 Apr 23;12:955-966.

Quercetin hydrate/槲皮素水合物动物实验

Species C57BL/6 mice MRL/lpr mice C57BL/6 mice Mice Mice Db/db mice	Animal Model Periodontitis model Systemic lupus erythematosus model Chronic cough model Sod1KO mice Triple transgenic Alzheimer’s disease model mice (3xTg-AD) Type 2 diabetes model	Administration	Dosage	Frequency	Description	References
C57BL/6 mice	Periodontitis model	Oral gavage	50 mg/kg	Once daily for 10 days	Quercetin reduced the oxidative stress level and slowed the absorption of alveolar bone in mice with periodontitis by activating the NRF2 signaling pathway.	Drug Des Devel Ther. 2021 Aug 12;15:3509-3522.
MRL/lpr mice	Systemic lupus erythematosus model	Gavage	40 mg/kg	Daily for three months	Quercetin improved renal function and inhibited fibrosis- and inflammation-related markers in MRL/lpr mice.	Antioxidants (Basel). 2022 Nov 13;11(11):2238.
C57BL/6 mice	Chronic cough model	Oral	150 mg/kg	Twice daily for seven days	Quercetin significantly decreased the frequency of coughing in mice, indicating its cough-relieving effect via acting at P2X3 receptors.	Nat Commun. 2023 Sep 20;14(1):5844.
Mice	Sod1KO mice	Oral	50 mg/kg	Three consecutive days every 15 days for 7 months	D + Q treatment significantly reduced the expression of p16 and SASP factors (such as IL-6, IL-1β, CXCL-1, and GDF-15) in the livers of Sod1KO mice, and reduced markers of inflammation and the incidence of hepatocellular carcinoma.	Aging Cell. 2022 Aug;21(8):e13676
Mice	Triple transgenic Alzheimer’s disease model mice (3xTg-AD)	Oral	100 mg/kg	Every 48 hours for one year	To evaluate the effect of long-term oral administration of quercetin on neurodegeneration markers and cognitive function in Alzheimer’s disease model mice. The results showed that quercetin significantly reduced β-amyloid accumulation and partially improved cognitive function.	Molecules. 2019 Jun 20;24(12):2287
Db/db mice	Type 2 diabetes model	Intragastric administration	0.5 g/kg	Once daily for 4 weeks	To evaluate the effect of quercetin on glucose tolerance and insulin secretion in db/db mice, results showed that quercetin significantly improved glucose tolerance and insulin secretion	Drug Des Devel Ther. 2018 Apr 23;12:955-966.

Species

C57BL/6 mice MRL/lpr mice C57BL/6 mice Mice Mice Db/db mice

Animal Model

Periodontitis model Systemic lupus erythematosus model Chronic cough model Sod1KO mice Triple transgenic Alzheimer’s disease model mice (3xTg-AD) Type 2 diabetes model

Administration

Dosage

Frequency

Description

References

C57BL/6 mice

Periodontitis model

Oral gavage

50 mg/kg

Once daily for 10 days

Quercetin reduced the oxidative stress level and slowed the absorption of alveolar bone in mice with periodontitis by activating the NRF2 signaling pathway.

Drug Des Devel Ther. 2021 Aug 12;15:3509-3522.

MRL/lpr mice

Systemic lupus erythematosus model

Gavage

40 mg/kg

Daily for three months

Quercetin improved renal function and inhibited fibrosis- and inflammation-related markers in MRL/lpr mice.

Antioxidants (Basel). 2022 Nov 13;11(11):2238.

C57BL/6 mice

Chronic cough model

Oral

150 mg/kg

Twice daily for seven days

Quercetin significantly decreased the frequency of coughing in mice, indicating its cough-relieving effect via acting at P2X3 receptors.

Nat Commun. 2023 Sep 20;14(1):5844.

Mice

Sod1KO mice

Oral

50 mg/kg

Three consecutive days every 15 days for 7 months

D + Q treatment significantly reduced the expression of p16 and SASP factors (such as IL-6, IL-1β, CXCL-1, and GDF-15) in the livers of Sod1KO mice, and reduced markers of inflammation and the incidence of hepatocellular carcinoma.

Aging Cell. 2022 Aug;21(8):e13676

Mice

Triple transgenic Alzheimer’s disease model mice (3xTg-AD)

Oral

100 mg/kg

Every 48 hours for one year

To evaluate the effect of long-term oral administration of quercetin on neurodegeneration markers and cognitive function in Alzheimer’s disease model mice. The results showed that quercetin significantly reduced β-amyloid accumulation and partially improved cognitive function.

Molecules. 2019 Jun 20;24(12):2287

Db/db mice

Type 2 diabetes model

Intragastric administration

0.5 g/kg

Once daily for 4 weeks

To evaluate the effect of quercetin on glucose tolerance and insulin secretion in db/db mice, results showed that quercetin significantly improved glucose tolerance and insulin secretion

Drug Des Devel Ther. 2018 Apr 23;12:955-966.

Quercetin hydrate/槲皮素水合物参考文献

Quercetin hydrate/槲皮素水合物实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.12mL

0.62mL

0.31mL

15.61mL

3.12mL

1.56mL

31.23mL

6.25mL

3.12mL

Quercetin hydrate/槲皮素水合物技术信息

CAS号	849061-97-8
分子式	C₁₅H₁₂O₈
分子量	320.25
SMILES Code	OC1=C(OC2=C(C1=O)C(O)=CC(O)=C2)C3=CC=C(C(O)=C3)O.[H]O[H]
MDL No.	MFCD00006828

别名	Quercetin (hydrate)
运输	蓝冰

存储条件	In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, room temperature

Quercetin hydrate/槲皮素水合物 {[allProObj[0].p_purity_real_show]}

Quercetin hydrate/槲皮素水合物纯度/质量文件产品仅供科研

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Quercetin hydrate/槲皮素水合物质控信息

Quercetin hydrate/槲皮素水合物生物活性

Quercetin hydrate/槲皮素水合物细胞实验

Quercetin hydrate/槲皮素水合物动物实验

Quercetin hydrate/槲皮素水合物参考文献

Quercetin hydrate/槲皮素水合物实验方案

Quercetin hydrate/槲皮素水合物技术信息

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Quercetin hydrate/槲皮素水合物 {[allProObj[0].p_purity_real_show]}

Quercetin hydrate/槲皮素水合物 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Quercetin hydrate/槲皮素水合物 质控信息

Quercetin hydrate/槲皮素水合物 生物活性

Quercetin hydrate/槲皮素水合物 细胞实验

Quercetin hydrate/槲皮素水合物 动物实验

Quercetin hydrate/槲皮素水合物 参考文献

Quercetin hydrate/槲皮素水合物 实验方案

Quercetin hydrate/槲皮素水合物 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Quercetin hydrate/槲皮素水合物纯度/质量文件产品仅供科研

Quercetin hydrate/槲皮素水合物质控信息

Quercetin hydrate/槲皮素水合物生物活性

Quercetin hydrate/槲皮素水合物细胞实验

Quercetin hydrate/槲皮素水合物动物实验

Quercetin hydrate/槲皮素水合物参考文献

Quercetin hydrate/槲皮素水合物实验方案

Quercetin hydrate/槲皮素水合物技术信息