There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
NSC 146109 HCl is a small molecule p53 activator targeting MDMX for breast cancer research. NSC 146109 HCl is a pseudourea derivative that promotes apoptosis in breast cancer cells by activating p53 and inducing expression of pro-apoptotic genes[1].
NSC 146109 HCl 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MDA-MB-231 cells
0.5 µM
16 hours
XI-011 inhibits MDMX expression in p53 mutant cells.
Neoplasia. 2011 Jul;13(7):611-9
MCF-7 cells
0.5 µM
16 hours
XI-011 activates p53 by inhibiting MDMX expression, leading to apoptosis in breast cancer cells.
Neoplasia. 2011 Jul;13(7):611-9
Primary mouse lung fibroblasts
1 µM
24 hours
XI-011 significantly reduced MDM4 protein levels
Theranostics. 2023 May 8;13(9):2787-2799
Primary human lung fibroblasts
1 µM
24 hours
XI-011 significantly reduced MDM4 protein levels
Theranostics. 2023 May 8;13(9):2787-2799
NSC 146109 HCl 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Bleomycin-induced lung fibrosis model
Intratracheal inhalation
1 mM/kg，50 μl
Every other day for a total of 10 times
XI-011 significantly reduced Mdm4 protein levels in fibrotic mice and decreased the expression of Col1a1, FN1, and αSMA, improving lung fibrosis
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