NSC 146109 HCl

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Chemical Structure| 59474-01-0 同义名 : NSC 146109 (hydrochloride); XI-011; NSC 146109 hydrochloride
CAS号 : 59474-01-0
货号 : A259495
分子式 : C17H17ClN2S
纯度 : 99%+
分子量 : 316.85
MDL号 : MFCD07783997
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(268.27 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 NSC 146109 HCl is a small molecule p53 activator targeting MDMX for breast cancer research. NSC 146109 HCl is a pseudourea derivative that promotes apoptosis in breast cancer cells by activating p53 and inducing expression of pro-apoptotic genes[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.16mL

0.63mL

0.32mL

15.78mL

3.16mL

1.58mL

31.56mL

6.31mL

3.16mL
参考文献

[1]Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13(7):611-9.