There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
To treat allergic asthma, nonsympathomimetic drugs have been developed that act prophylactically by inhibiting the release of mast cell mediators. Lodoxamide tromethamine is a new drug intended for the prophylaxis of mast cell-mediated allergic disease. In vitro, lodoxamide inhibited compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibited the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized, anesthetized rhesus monkeys. Doses as low as 1 μg by aerosol 30 min prior to challenge effectively prevented lung function changes induced by allergen. Ten allergen-sensitive asthmatics were pretreated with lodoxamide (0.01, 0.1, or 1.0 mg) or placebo. Pretreatment with lodoxamide offered significant protection against experimental allergen-induced bronchoconstriction. At 0.01 mg, lodoxamide was effective in over half the subjects tested. Administration of lodoxamide by inhalation at doses of 0.1 and 1.0 mg uniformly allowed subjects to tolerate significantly larger doses of inhaled allergen[3].
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