There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Levocetirizine 2HCl ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[3]. Levocetirizine has modest sedative effects with a risk ratio of 1.67 when compared with placebo[4]. Montelukast, levocetirizine and their combination is equally effective in controlling symptoms, of allergic rhinitis[5]. Male Sprague Dawley rats received either levocetirizine (1 mg/kg/day, orally) or the vehicle of the drug (2 ml/kg/day, orally) for 1 week before a single IP injection of LPS (7.5 mg/kg). Levocetirizine attenuated lung edema and mitigated the increases in BALF (bronchoalveolar lavage fluid) protein levels, LDH (lactate dehydrogenase) activity, and lung leukocyte recruitment in LPS-challenged rats. Additionally, TNF-α protein levels in BALF and lung tissue were diminished by levocetirizine administration. Levocetirizine may offer protection against lung tissue damage and inflammation in LPS-challenged rats[6].
Levocetirizine 2HCl/左西替利嗪二盐酸盐 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Children
Patients with allergic rhinitis
Oral
5 mg
Once every evening for 4 weeks
To evaluate the safety and efficacy of levocetirizine and montelukast combination therapy in children with allergic rhinitis. Results showed that combination therapy was more effective than monotherapy in reducing both daytime and nighttime nasal symptoms.
To evaluate the effects of Levocetirizine on behavioral and biochemical parameters in a Parkinson's disease model in mice. Results showed that Levocetirizine significantly improved motor coordination, reduced catalepsy, and enhanced antioxidant enzyme activities.
ACS Omega. 2022 Apr 20;7(17):14772-14783
Wistar rats
Atopic dermatitis and MRSA skin infection model
Topical administration
7.5 mg LVC
1 day
Evaluate the deposition and safety of levocetirizine in the skin
Pharmaceuticals (Basel). 2025 Apr 27;18(5):633
Male Wistar rats
Alopecia model
Topically
2.5 mg/mL
Single dose, duration of 10 hours
To evaluate the skin deposition of LVC from CCPCs, results showed that the AUC0-10 of the CCPCs group was significantly higher than that of the LVC solution group, indicating increased LVC deposition in the skin.
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