There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine acts via H1 and H2 receptors to produce vasodilation and increased vascular permeability; elevated levels of histamine are found in inflamed tissue[3]. Bilateral EP (experimental periodontitis) was induced for 2 weeks and histamine treatment (0.1 mg/kg subcutaneously) was started 5 days before the end of the experimental period in male rats. Histamine treatment partially reversed the methacholine-induced salivation reduction produced by EP while preventing SMG (submandibular gland) histological damage. Furthermore, histamine completely prevented enhanced EP-induced apoptosis. Histamine is able to reduce periodontitis-induced damage to SMG and bone structure[4]. Histamines play an important role as a neurotransmitter in the central nervous system and participate in several physiological functions, such as the regulation of body temperature, food intake, circadian rhythm and analgesia. Histamines facilitate memory performance in mice[5]. In HL-60 cells, histamine and 2-methylhistamine increased cytosolic Ca2+ concentration ([Ca2+]i) in a clemastine-sensitive manner. Histamine and 2-methylhistamine act as H1-receptor agonists in HL-60 cells[6].
Histamine/组胺 细胞实验
Cell Line
Concentration
Treated Time
Description
References
human airway smooth muscle cells
10 μM
~127 seconds delay before shortening
Study histamine-induced cell contraction and shortening
ACS Nano. 2021 Jul 27;15(7):11585-11596
HEK293T cells
2.5 μM
30 minutes
Identified CG1358 (HisT) as a histamine-specific transporter, whose transport activity is Na+-dependent but Cl−-independent, and highly specific to histamine
Sci Adv. 2022 Oct 28;8(43):eabq1780
CINs (cholinergic interneurons)
10 μM
To assess the effects of histamine on CIN excitability, results showed histamine significantly increased spontaneous firing frequency of CINs
To assess the effects of histamine on PV-IN excitability and resting membrane potential, results showed no significant effect of histamine on PV-IN excitability or resting membrane potential
Biol Psychiatry. 2023 Jun 1;93(11):1041-1052
human induced pluripotent stem cells (hiPSCs)
10 μM
3-5 days
promoted cardiac progenitor cell generation and cardiomyocyte differentiation
Stem Cell Res Ther. 2020 Mar 4;11(1):27
HeLa cells
30 μM
1 min
The IC50 value of the inhibition of histamine (30 μM, 1 min)-induced Ca2+ rise was 951 nM for cetirizine/DBD-pz, which is equivalent to the IC50 value of cetirizine (867 nM)
搜索
HazMat Fee +
