Sterile PBS or 0.9% saline for reconstitution/dilution. It is recommended to use the reconstituted/diluted product within one month.
Atezolizumab/阿特珠单抗 细胞实验
Cell Line
Concentration
Treated Time
Description
References
143B cells
0, 2.5, 5, 10, 20, 40 µg/ml
24 hours
To evaluate the inhibitory effect of Atezolizumab on the proliferation of 143B cells. Results showed that Atezolizumab inhibited the proliferation of 143B cells in a dose-dependent manner.
Cell Death Dis. 2021 Feb 8;12(2):164.
HOS cells
0, 2.5, 5, 10, 20, 40 µg/ml
24 hours
To evaluate the inhibitory effect of Atezolizumab on the proliferation of HOS cells. Results showed that Atezolizumab inhibited the proliferation of HOS cells in a dose-dependent manner.
Cell Death Dis. 2021 Feb 8;12(2):164.
Atezolizumab/阿特珠单抗 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Severe combined immunodeficient mice
HOS cell xenograft tumor model
Intraperitoneal injection
10 mg/kg
Once daily for 3 weeks
To evaluate the inhibitory effect of Atezolizumab alone or in combination with chloroquine on the growth of HOS xenograft tumors. Results showed that Atezolizumab significantly inhibited tumor growth, and the effect was more pronounced when combined with chloroquine.
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