There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Recommended Dilution Buffer: Sterile PBS or 0.9% saline for reconstitution/dilution. It is recommended to use the reconstituted/diluted product within one month.
Formulation: 100 mM Pro-Ac，20 mM Arg，pH5.0
Endotoxin: < 0.001EU/μg, determined by LAL method.
Purity: >95%. Determined by SDS-PAGE
Purification: Purified, Protein A, affinity column
Storage: -80°C for 2 years under sterile conditions；
-20°C for 1 year under sterile conditions；
Avoid repeated freeze-thaw cycles.
Isotype: IgG4SP-Kappa
Pembrolizumab/帕博利珠单抗 细胞实验
Cell Line
Concentration
Treated Time
Description
References
SFMCs (21-day culture)
5 μg/mL
21 days
To investigate the effect of Pembrolizumab on TRAP secretion in SFMCs, results showed Pembrolizumab did not significantly increase TRAP secretion (P = 0.28).
Arthritis Res Ther. 2022 Feb 14;24(1):43
Human EA.hy926 endothelial cells
100 μg/ml
24 hours
Study the toxic effect of Pembrolizumab on endothelial cells, finding that atorvastatin could prevent this toxicity
Basic Res Cardiol. 2025 Feb;120(1):263-286
Splenocytes
0-100 μg/ml
24 hours
Assess the effect of ICIs on immune cells, finding that Pembrolizumab at high doses induced increased Th17-type cytokine expression
Basic Res Cardiol. 2025 Feb;120(1):263-286
Human spermatozoa
1-100 ng/mL
4 hours
To evaluate the effect of Pembrolizumab on human sperm motility. Results showed that Pembrolizumab significantly reduced sperm motility at concentrations of 10 ng/mL and above.
Front Pharmacol. 2025 Mar 31;16:1534975
PBMCs
5 µg/mL pembroliz µMab and 1 µg/mL rhGal-3
48 hours
Investigate the effect of Gal-3 and pembrolizumab on IL-2 production, results showed Gal-3 significantly decreased IL-2 production and pembrolizumab could not rescue it
J Immunother Cancer. 2024 Oct 2;12(10):e009952
FLS-PBMC co-cultures
5 μg/mL
48 hours
To investigate the effect of Pembrolizumab on MMP-3 production in FLS-PBMC co-cultures, results showed Pembrolizumab did not significantly increase MMP-3 production (P = 0.76).
Arthritis Res Ther. 2022 Feb 14;24(1):43
PBMCs from healthy controls
5 μg/mL
48 hours
To investigate the effect of Pembrolizumab on MCP-1 production in PBMCs from healthy controls, results showed Pembrolizumab did not significantly increase MCP-1 production (P = 0.43).
Arthritis Res Ther. 2022 Feb 14;24(1):43
Peripheral blood mononuclear cells (PBMCs)
5 μg/mL
48 hours
To investigate the effect of Pembrolizumab on MCP-1 production in PBMCs, results showed Pembrolizumab did not significantly increase MCP-1 production (P = 0.77).
Arthritis Res Ther. 2022 Feb 14;24(1):43
Synovial fluid mononuclear cells (SFMCs)
5 μg/mL
48 hours
To investigate the effect of Pembrolizumab on MCP-1 production in SFMCs, results showed Pembrolizumab significantly increased MCP-1 production (P = 0.0031).
Arthritis Res Ther. 2022 Feb 14;24(1):43
Pembrolizumab/帕博利珠单抗 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Human Pdcd1 transgenic mice
B16F10-R tumor model
Intravenous injection
10 mg/kg
Twice a week
To investigate the role of COX2 in acquired resistance to anti-PD-1 treatment
Cancers (Basel). 2022 Aug 26;14(17):4134
C57BL6/J male mice
Nontumor-bearing mice
Intraperitoneal
2 mg/kg
Weekly for 2 and 5 weeks
Establish a model of Pembrolizumab-induced cardiotoxicity, finding that Pembrolizumab caused coronary endothelial and diastolic dysfunction at 2 weeks and systolic dysfunction at 5 weeks
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