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首页 / 抑制剂/激动剂 / 细胞周期 / Chk

货号 产品名 纯度
A1177212 现货 CHK1-IN-3

CHK1-IN-3是一种高效的检测点激酶 1 (CHK1) 抑制剂,IC50 为 0.4 nM。CHK1-IN-3 可通过阻断 DNA 损伤应答途径,在癌症治疗中表现出潜在的应用价值。

95%
A690852 现货 GDC-0575

GDC-0575 is a potent and selective CHK1 inhibitor.

99%+
A547402 现货 SAR-020106

SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC (50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G (2) arrest with an IC (50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.

98%
A1365050 现货 ANI-7

ANI-7是一种 AhR 通路激活剂,能够通过激活 AhR 途径抑制多种癌细胞的生长,尤其对 MCF-7 乳腺癌细胞具有选择性抑制作用,GI50 为 0.56 μM,适用于乳腺癌和其他癌症的研究。

98%
A465968 现货 SB-218078

Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.

98%
A869154 现货 SCH900776 (S-isomer)

SCH-900776 is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM).

98%
A165759 现货 AZD-7762

AZD-7762是一种强效的 ATP 竞争性检查点激酶 (Chk) 抑制剂,对 Chk1IC50 为 5 nM。

99%+
A853008 现货 Prexasertib

LY2606368 is a potent and selective ATP competitive inhibitor (IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase.

99%+
A141550 现货 Rabusertib

Rabusertib(LY2603618) 是一种高效且选择性的 Chk1 抑制剂,IC50 为 7 nM。

99%+
A191306 现货 Prexasertib 2HCl

LY2606368 (Prexasertib) is a selective Chk1 inhibitor with IC50 value <1nM, modest to Chk2 and Rsk with IC50 values of 8nM and <10nM.

98%
A464575 现货 PF-477736

PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes and shows ~100-fold selectivity for Chk1 than Chk2.

98%+
A699007 现货 CCT241533 HCl

CCT241533 HCl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM and shows minimal cross-reactivity against a panel of kinases at 1 μM.

99%
A144417 现货 BML-277/Chk2抑制剂II

BML-277 is a selective Chk2 (checkpoint kinase 2) inhibitor with IC50 of 15 nM.

99%+
A433196 现货 CCT245737

CCT245737 is a potent, ATP-competitive CHK1 inhibitor with an IC50 of 30-220 nM.

97+%
A200833 现货 SCH900776

SCH 900776 (MK-8776) is a selective and highly potent CHK1 inhibitor with IC50 value of 3nM, modest to CDK2 and Chk2 with much higher IC50 values of 160nM and 1.5uM, respectively.

99%+
A241808 现货 CHIR-124/CHIR-124游离态

CHIR-124 is a potent Chk1 inhibitor with IC50 of 0.3 nM with 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.

98%
A1177301 现货 Prexasertib Mesylate Hydrate

Prexasertib, also known as LY2606368, is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.

99%+
A709241 VRX0466617

98%
A525147 PV-1019

95%
A1177764 CHK-IN-1

产品名 Chk1 Chk2 其他靶点 纯度
Rabusertib ++

Chk1, IC50: 7 nM

99%+
PF-477736 ++++

Chk1, Ki: 0.49 nM

98%+
Prexasertib 2HCl ++++

Chk1, Ki: 0.9 nM

++

Chk2, IC50: 8 nM

RSK 98%
AZD-7762 +++

Chk1, IC50: 5 nM

++

Chk2, IC50: <10 nM

99%+
CHIR-124 ++++

Chk1, IC50: 0.3 nM

PDGFR,FLT3,GSK-3 98%
SCH900776 +++

Chk1, IC50: 3 nM

99%+
SAR-020106 +

Chk1, IC50: 13.3 nM

98%
CCT245737 +++

Chk1, IC50: 1.4 nM

97+%
BML-277 +

Chk2, IC50: 15 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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