ITX3是一种特异性且无毒的TrioN抑制剂，IC50为76 μM，能够抑制TrioN刺激的RhoG交换反应。

Rhosin HCl是一种特异性的 RhoA 抑制剂，其亲和力约为 0.4 μM Kd，且不干扰 Cdc42 或 Rac1 的结合。

ML-098是一种 GTP 结合蛋白 Rab7 的激活剂，EC50 为 77.6 nM。

MLS000532223是一种高亲和力、选择性的Rho家族GTP酶抑制剂，EC50范围为16 μM到120 μM。小GTP酶是细胞活动的关键调节因子。

CCG-1423抑制 RhoA/C 介导的基因转录和 Rho 超表达细胞系的侵袭。

Narciclasine是一种植物生长调节剂。Narciclasine调节Rho/Rho激酶/LIM激酶/cofilin信号通路，显著增加RhoA的GTP酶活性，并依赖RhoA诱导肌动蛋白应力纤维的形成。

Y16是一种 G 蛋白偶联 Rho GEFs 的抑制剂，能够与 Rhosin/G04 协同作用，抑制 LARG-RhoA 相互作用、RhoA 激活及 RhoA 介导的信号功能。

BQU57显示出对Ral的选择性抑制作用，优于Ras或Rho，并且能够抑制异种移植肿瘤的生长，效果与通过siRNA去除Ral相似。

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras (G12C).

Rho-Kinase-IN-1 is a rho kinase inhibitor extracted from US 20090325960 A1, compound 1.008.

CCG-232601 is an inhibitor of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.

CCG-222740 is a Rho/MRTF pathway inhibitor. It decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin (α-SMA) expression. It also modulates inflammatory components of the pancreas in KC mice (LSL-KrasG12D/+; Pdx-1-Cre) stimulated with caerulein.

Rhosin is a specific Rho inhibitor which binds to WT RhoA with an affinity ~0.4 μM Kd while does not interfere with the binding of Cdc42 or Rac1.

Zoledronic acid, a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.