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货号 产品名 纯度
A1352007 现货 MLS000532223

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. Small GTPases are key regulators of cellular activity .

99%+
A559382 现货 BQU57

BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA.

98+%
A970865 现货 ITX3

ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 μM and inhibits TrioN-stimulated RhoG exchange in vitro.

98%+
A708952 现货 Rhosin HCl

Rhosin HCl is a specific Rho inhibitor which binds to WT RhoA with an affinity ~0.4 μM Kd while does not interfere with the binding of Cdc42 or Rac1.

99%+
A736431 现货 ML-098

ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM

99%
A381687 现货 CCG-1423

CCG-1423 inhibits RhoA/C-mediated gene transcription and the invasion of rho-overexpressing cell lines.

99%+
A225129 现货 Narciclasine/水仙环素

Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

99%+
A418195 现货 Y16

Y16 is an inhibitor of G-protein–coupled Rho GEFs and works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions.

98%
A175125 K-Ras(G12C) inhibitor 9

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras (G12C).

98+%
A873818 Rho-Kinase-IN-1

Rho-Kinase-IN-1 is a rho kinase inhibitor extracted from US 20090325960 A1, compound 1.008.

98%
A2791387 MLS000532223

99%
A200588 CCG-232601

CCG-232601 is an inhibitor of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.

98+%
A364741 Zoledronic Acid/唑来膦酸

Zoledronic acid, a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.

98%
A1213276 CCG-222740

CCG-222740 is a Rho/MRTF pathway inhibitor. It decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin (α-SMA) expression. It also modulates inflammatory components of the pancreas in KC mice (LSL-KrasG12D/+; Pdx-1-Cre) stimulated with caerulein.

99%+
A706953 Rhosin

Rhosin is a specific Rho inhibitor which binds to WT RhoA with an affinity ~0.4 μM Kd while does not interfere with the binding of Cdc42 or Rac1.

98+%
A2795429 BQU57

99+%
A2792335 Rhosin HCl

99+%
A2791629 CCG-1423

99%
A2792017 Narciclasine/水仙环素

99%
A2795724 Y16

99%
产品名 Cdc42-subclass Rac Rho-subclass 其他靶点 纯度
ZCL278 ++

Cdc42 GTPase, Kd: 11.4 μM

98%
ML141 +++

cdc42, IC50: 200 nM

99%+
NSC 23766 3HCl +

Rac GTPase, IC50: 50 μM

98%
EHop-016 +++

Rac1, IC50: 1.1 μM

98%
Azathioprine 98%
EHT 1864 ++++

Rac1, Kd: 40 nM

Rac3, Kd: 50 nM

99%+
Zoledronic Acid Ras 98%
CCG-1423 99%+
CCG-203971 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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