货号:A101947
同义名:
硫唑嘌呤
/ BW 57-322; Azamune
Azathioprine 能够抑制 GTP 结合蛋白 Rac1 的激活及嘌呤合成,常被用于器官移植及自身免疫性疾病的研究。


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| 靶点 |
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| 描述 | Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. |
| Concentration | Treated Time | Description | References | |
| PANC1 cells | 5 μM | 48 hours | Azathioprine had no effect on invasive migration of Vav1-negative cells | Cancer Res. 2015 Jul 15;75(14):2907-15. |
| DanG cells | 5 μM | 48 hours | Azathioprine significantly inhibited invasive migration of Vav1-positive cells | Cancer Res. 2015 Jul 15;75(14):2907-15. |
| Administration | Dosage | Frequency | Description | References | ||
| Swiss mice | Normal mice and inflammation model | Subcutaneous injection | 3 mg/kg | Once daily for 4 to 9 days | To study the effect of Azathioprine on monocyte production, results showed high dose Azathioprine significantly inhibited monocyte production. | J Exp Med. 1975 Mar 1;141(3):531-46 |
| Nude mice | Xenograft model | Intraperitoneal injection | 5 mg/kg | Three times per week for 3-4 weeks | Azathioprine significantly reduced metastasis of Vav1-positive tumors | Cancer Res. 2015 Jul 15;75(14):2907-15. |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00745329 | - | Unknown | - | - | |
| NCT01235689 | Crohn's Disease | Phase 3 | Completed | - | - |
| NCT00615173 | Kidney Diseases ... 展开 >> Lupus Nephritis Tacrolimus Induction Phase Maintenance Phase 收起 << | Phase 3 | Completed | - | China, Guangdong ... 展开 >> The 1st Affiliated Hospital, Sun Yet-sen University Guangzhou, Guangdong, China, 510080 收起 << |
| 计算器 | ||||
| 存储液制备 | ![]() |
1mg | 5mg | 10mg |
|
1 mM 5 mM 10 mM |
3.61mL 0.72mL 0.36mL |
18.03mL 3.61mL 1.80mL |
36.07mL 7.21mL 3.61mL |
|
| CAS号 | 446-86-6 |
| 分子式 | C9H7N7O2S |
| 分子量 | 277.26 |
| SMILES Code | O=[N+](C1=C(SC2=C3N=CNC3=NC=N2)N(C)C=N1)[O-] |
| MDL No. | MFCD00055974 |
| 别名 | 硫唑嘌呤 ;BW 57-322; Azamune; NSC 39084; Imuran; Azoran |
| 运输 | 蓝冰 |
| InChI Key | LMEKQMALGUDUQG-UHFFFAOYSA-N |
| Pubchem ID | 2265 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
| 溶解方案 |
DMSO: 50 mg/mL(180.33 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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