There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Rho GTPases are molecular switches that regulate many essential cellular processes, including actin dynamics, gene transcription, cell-cycle progression and cell adhesion[3]. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression[4]. CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. CCG-1423 selectively inhibited spontaneous PC-3 prostate cancer cell invasion through a Matrigel matrix in vitro, but not the Gαi-dependent LPA-stimulated SKOV-3 ovarian cancer cell invasion in vitro. At 100 μM, nearly complete inhibition of invasion was achieved with a lesser degree of toxicity than that induced by CCG-1423 at 10 μM[5]. Pharmacological SRF inhibition by CCG-1423 reduced nuclear MKL1 and improved glucose uptake and tolerance in insulin-resistant mice in vivo[6]. SRF binds to this site in vivo and the SRF inhibitor CCG-1423 completely blocks STARS proximal reporter activity in H9c2 cells[7]. Pharmacological MKL-inhibition with CCG-1423 significantly inhibited CCN1 promoter activity as well as mRNA and protein expression[8].
CCG-1423 细胞实验
Cell Line
Concentration
Treated Time
Description
References
AGS
7.5 μM
CCG-1423 effectively inhibited GC cells' invasion and MYH9 expression
Theranostics. 2017 Aug 2;7(13):3338-3353.
MGC 80-3
7.5 μM
CCG-1423 effectively inhibited GC cells' invasion and MYH9 expression
CCG-1423 reversed palmitate-induced MKL1 nuclear localization, resulting in predominant localization of MKL1 to the cytosol.
J Clin Invest. 2011 Mar;121(3):918-29.
L6 myotubes
1 μM
16 h
CCG-1423 increased both basal and insulin-stimulated glucose uptake and blocked SRF activity by inhibiting MKL1 nuclear localization.
J Clin Invest. 2011 Mar;121(3):918-29.
HmVEC
0.5, 1, 2.5, 5 µM
24 h
CCG-1423 significantly inhibited the cord-forming ability of HmVEC, with 45% inhibition at 1 µM, 80% inhibition at 2.5 µM, and almost complete inhibition at 5 µM.
Angiogenesis. 2017 Nov;20(4):663-672.
A10 VSMCs
0.1 μM
30 min
CCG-1423 partially blocked the inhibitory effect of MYDGF on PDGF-BB-induced phenotypic switching in A10 VSMCs
Acta Pharmacol Sin. 2024 Jan;45(1):98-111.
RH30 cells
10 µM
5 h
CCG-1423 and PAX3-FOXO1 showed a significant synergistic effect in suppressing ACTA1 reporter activity.
Cell Biosci. 2021 Jan 28;11(1):25.
TW03
80.55 μM
24 h
CCG-1423 reversed the migration and invasion abilities of Nogo-B and NgR3, and downregulated the expression of N-Cadherin and MRTFA
Cell Death Dis. 2022 Jan 24;13(1):76.
HK1
30.19 μM
24 h
CCG-1423 reversed the migration and invasion abilities of Nogo-B and NgR3, and downregulated the expression of N-Cadherin and MRTFA
Cell Death Dis. 2022 Jan 24;13(1):76.
RH30 cells
10 µM
5 h
Observed significant synergistic effect between PAX3-FOXO1 and CCG-1423 to suppress ACTA1 reporter activity
Cell Biosci. 2021 Jan 28;11(1):25.
CCG-1423 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
HFD-induced obese mice
Intraperitoneal
0.15 mg/kg
Once daily for 2 weeks
CCG-1423 improved glucose tolerance in HFD-fed mice and decreased expression of SRF targets in skeletal muscle.
J Clin Invest. 2011 Mar;121(3):918-29.
Nude mice
Orthotopic-transplant nude-mouse models of GC
Intraperitoneally
0.15 mg/kg
Every 2 weeks for 2 weeks
The tumor volumes of CCG-1423-treated group were smaller than the control group, and the metastatic nodules were also significantly less in CCG-1423-treated group
Theranostics. 2017 Aug 2;7(13):3338-3353.
Mice
Carotid artery ligation model
Intraperitoneal injection
1 mg/kg
Daily for 4 weeks
CCG-1423 inhibited neointima formation after carotid artery ligation
Redox Biol. 2023 Feb;59:102586.
Zebrafish
Tg(kdrl:gfp)la116 zebrafish embryos
Directly added to water
0.5, 1 µM
22 hours
CCG-1423 at 1 μM significantly inhibited angiogenesis in zebrafish embryos, marked by reduced ISV (intersegmental vessel) formation and incomplete extension.
Angiogenesis. 2017 Nov;20(4):663-672.
Mice
CAP2-CKO mouse model
Intraperitoneal injection
0.15 mg/kg
Once daily for 21 days
To evaluate the effect of CCG-1423-8u on cardiac function and survival in CAP2-CKO mice, results showed that CCG-1423-8u significantly extended survival and improved cardiac function
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