WYE-132

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Chemical Structure| 1144068-46-1 同义名 : WYE-125132
CAS号 : 1144068-46-1
货号 : A686362
分子式 : C27H33N7O4
纯度 : 99%+
分子量 : 519.6
MDL号 : MFCD22420813
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(48.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • mTOR

    mTOR, IC50:0.19 nM
描述 WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM, highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
LNCAP cells Cytotoxicity assay Cytotoxicity against human LNCAP cells, IC50=0.002 μM 20089401
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.62mL

1.92mL

0.96mL

19.25mL

3.85mL

1.92mL
参考文献

[1]Yu K, Shi C, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res. 2010 Jan 15;70(2):621-31.

[2]Shor B, Wu J, et al. Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J Biol Chem. 2010 May 14;285(20):15380-92.