Tetrahydropalmatine | DL-Tetrahydropalmatine | 四氢帕马丁 | Plant Standard | Dopamine Receptor

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Tetrahydropalmatine/延胡索乙素 {[allProObj[0].p_purity_real_show]}

货号：A482970 同义名： 四氢帕马丁 / DL-Tetrahydropalmatine

Tetrahydropalmatine是一种主要在裂叶草属（Corydalis）中发现的异喹啉生物碱，具有镇痛作用。它拮抗多巴胺D1和D2受体，并在D3、α-肾上腺素能和5-羟色胺受体上有作用，对D1和D2多巴胺受体的Ki值分别为124 nM和388 nM。

Tetrahydropalmatine/延胡索乙素化学结构
CAS号：2934-97-6

Tetrahydropalmatine/延胡索乙素 3D分子结构
CAS号：2934-97-6

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Tetrahydropalmatine/延胡索乙素纯度/质量文件产品仅供科研

货号：A482970 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Nat. Electron., 2025, 8, 66-74. Ambeed. [ A100095 ]; • Adv. Mater., 2025, 2416621. Ambeed. [ A255324 , A420052 ]; • Adv. Mater., 2025, 2410493. Ambeed. [ A838608 ]; • Adv. Mater., 2025, 2420319. Ambeed. [ A106129 ]; 更多 >

多巴胺受体亚型比较

产品名称	D1 receptor ↓ ↑	D2 receptor ↓ ↑	D3 receptor ↓ ↑	D4 receptor ↓ ↑	D5 receptor ↓ ↑	DAT ↓ ↑	Dopamine receptor ↓ ↑	其他靶点	纯度
Penfluridol	+ Dopamine receptor, Ki: 1.6 μM								98%
Ansofaxine HCl	++ Dopamine receptor, IC50: 491 nM								99%
Tetrahydroberberine		+ D2 receptor, pKi: 6.08							98+%
Prochlorperazine Maleate		✔							98% (HPLC)
Olanzapine		✔							99+%
Trifluoperazine		++++ Dopamine D2 receptor, IC50: 1.1 nM							98%
Ropinirole HCl		++ D2 receptor, Ki: 29 nM							99%
Lurasidone		++++ D2 receptor, Ki: 1 nM							98%
Levosulpiride		✔							99+%
Pridopidine		✔							95%
Metoclopramide		✔					✔		99+%
Molindone HCl		✔							99%
Sulpiride		✔							99+%
Perospirone		++++ D2 receptor, Ki: 1.4 nM							99%
Perospirone HCl		++++ D2 receptor, Ki: 1.4 nM							99%
Phenothiazine		✔							98%
Pimozide	+ Dopamine D1 receptor, Ki: 6600 nM	+++ Dopamine D2 receptor, Ki: 3.0 nM	++++ Dopamine D3 receptor, Ki: 0.83 nM						98%
Rotundine	++ D1 receptor, IC50: 166 nM	+ D2 receptor, IC50: 1.47 μM	+ D3 receptor, IC50: 3.25 μM						98%
Domperidone		✔							99+%
ONC206		✔							99%
Pimethixene maleate	++ Dopamine D1 Receptor, pKi: 6.37	+++ Dopamine D2 Receptor, pKi: 8.19		++ Dopamine D4.4 Receptor, pKi: 7.54					97%
Loxapine succinate	++ D1 receptor (human), Ki: 26 nM D2 receptor (Human), Ki: 62 nM	++ D2 receptor (human), Ki: 24 nM D2 receptor (bovine), Ki: 26 nM		+++ D4 receptor (human), Ki: 7.5 nM					98%
Chlorprothixene	+++ D1 receptor, Ki: 18 nM	+++ D2 receptor, Ki: 2.96 nM	+++ D3 receptor, Ki: 4.56 nM		+++ D5 receptor, Ki: 9 nM				99%
SCH-23390 HCl	++++ D1 dopamine receptor, Ki: 0.2 nM				++++ D5 dopamine receptor, Ki: 0.3 nM				98%
MPP+ iodide						✔			97%
σ1 Receptor antagonist-1						+ DAT, pKi: 5.8			97%
Benztropine mesylate						++ DAT, IC50: 118 nM			98%
Azaperone							✔		98%
Ziprasidone HCl							✔		98+%
Paliperidone							✔		98%
Alizapride HCl							✔		99+%
Amisulpride							✔		98%
Quetiapine hemifumarate							✔	Adrenergic Receptor	98%
Clozapine N-oxide							✔		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Tetrahydropalmatine/延胡索乙素生物活性

描述

Tetrahydropalmatine, one of the active components of rhizoma corydalis, exert several pharmacological effects, including anti-inflammatory, anti-tumor and analgesic activities. Tetrahydropalmatine did not exhibit any cellular toxicity up to 40 µM. Tetrahydropalmatine suppress lipid accumulation in 3T3-L1 cells and it inhibited pre-adipocyte differentiation in a concentration-dependent manner^[3]. Tetrahydropalmatine (80 mg/kg) may protect against ketamine-induced learning and memory impairment in mice via antioxidative, anti-inflammatory and anti-apoptotic mechanisms^[4].

Tetrahydropalmatine/延胡索乙素参考文献

[1]Zhang X, Guan J, et al. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:126-32.

[2]Lin YY, Wang YP, et al. Plasma pharmacokinetics and lung distribution of tetrahydropalmatine after topical application of cold asthma recipe extract: Feishu (BL 13) versus Non-Feishu acupoint. J Ethnopharmacol. 2014 Apr 28;153(2):454-60.

[3]Piao GC, Liu GC, Jin XJ, Jin D, Yuan HD. Tetrahydropalmatine inhibits lipid accumulation through AMPK signaling pathway in 3T3‑L1 adipocytes. Mol Med Rep. 2017 Jun;15(6):3912-3918. doi: 10.3892/mmr.2017.6473. Epub 2017 Apr 12. PMID: 28440456.

[4]Ben Khelil M, Kamel M, Lahmar S, Mrabet A, Borsali Falfoul N, Hamdoun M. Death certificate accuracy in a Tunisian Emergency Department. Tunis Med. 2017 Jun;95(6):422-428. PMID: 29512798.

Tetrahydropalmatine/延胡索乙素实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.07mL

2.81mL

1.41mL

28.13mL

5.63mL

2.81mL

Tetrahydropalmatine/延胡索乙素技术信息

CAS号	2934-97-6
分子式	C₂₁H₂₅NO₄
分子量	355.43
SMILES Code	COC1=C(OC)C(C2)=C(C=C1)CC3N2CCC4=C3C=C(OC)C(OC)=C4
MDL No.	MFCD00214191

别名	四氢帕马丁 ;DL-Tetrahydropalmatine
运输	蓝冰
InChI Key	AEQDJSLRWYMAQI-UHFFFAOYSA-N
Pubchem ID	5417

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, room temperature

溶解方案

细胞实验：

DMSO: 5 mg/mL(14.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

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Tetrahydropalmatine/延胡索乙素纯度/质量文件产品仅供科研

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Tetrahydropalmatine/延胡索乙素生物活性

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Tetrahydropalmatine/延胡索乙素实验方案

Tetrahydropalmatine/延胡索乙素技术信息