Tetrahydropalmatine

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Chemical Structure| 2934-97-6 同义名 : 四氢帕马丁 ;DL-Tetrahydropalmatine
CAS号 : 2934-97-6
货号 : A482970
分子式 : C21H25NO4
纯度 : 98%
分子量 : 355.43
MDL号 : MFCD00214191
存储条件:

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 5 mg/mL(14.07 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Tetrahydropalmatine, one of the active components of rhizoma corydalis, exert several pharmacological effects, including anti-inflammatory, anti-tumor and analgesic activities. Tetrahydropalmatine did not exhibit any cellular toxicity up to 40 µM. Tetrahydropalmatine suppress lipid accumulation in 3T3-L1 cells and it inhibited pre-adipocyte differentiation in a concentration-dependent manner[3]. Tetrahydropalmatine (80 mg/kg) may protect against ketamine-induced learning and memory impairment in mice via antioxidative, anti-inflammatory and anti-apoptotic mechanisms[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.07mL

2.81mL

1.41mL

28.13mL

5.63mL

2.81mL

参考文献

[1]Zhang X, Guan J, et al. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:126-32.

[2]Lin YY, Wang YP, et al. Plasma pharmacokinetics and lung distribution of tetrahydropalmatine after topical application of cold asthma recipe extract: Feishu (BL 13) versus Non-Feishu acupoint. J Ethnopharmacol. 2014 Apr 28;153(2):454-60.

[3]Piao GC, Liu GC, Jin XJ, Jin D, Yuan HD. Tetrahydropalmatine inhibits lipid accumulation through AMPK signaling pathway in 3T3‑L1 adipocytes. Mol Med Rep. 2017 Jun;15(6):3912-3918. doi: 10.3892/mmr.2017.6473. Epub 2017 Apr 12. PMID: 28440456.

[4]Ben Khelil M, Kamel M, Lahmar S, Mrabet A, Borsali Falfoul N, Hamdoun M. Death certificate accuracy in a Tunisian Emergency Department. Tunis Med. 2017 Jun;95(6):422-428. PMID: 29512798.