Schaftoside is a natural product isolated and purified from the herbs of Desmodium styracifolium (Osh.) Merr. with antioxidant and anticancer activities.
Schaftoside/夏佛塔苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Human liver microsomes
1 µM, 10 µM
1.5 hours
To evaluate the metabolic stability of schaftoside in human liver microsomes. Results showed that after 1.5 h incubation, the remaining amounts of schaftoside were 100.25 ± 1.04% (1μM) and 98.36 ± 1.34% (10 μM) of the initial amounts, indicating poor metabolism of schaftoside in human liver microsomes.
Front Pharmacol. 2022 Dec 14;13:1073535
Rat liver microsomes
1 µM, 10 µM
1.5 hours
To evaluate the metabolic stability of schaftoside in rat liver microsomes. Results showed that after 1.5 h incubation, the remaining amounts of schaftoside were 102.66 ± 2.41% (1μM) and 97.66 ± 3.30% (10 μM) of the initial amounts, indicating poor metabolism of schaftoside in rat liver microsomes.
Front Pharmacol. 2022 Dec 14;13:1073535
Vero E6 cells
11.83 ± 3.23 µM (EC50)
24 hours
Evaluate the inhibitory effect of Schaftoside on SARS-CoV-2 virus, showing significant antiviral activity
Acta Pharm Sin B. 2022 Nov;12(11):4154-4164
Caco-2 cells
10 µM and 100 µM
3 hours and 5 hours
Investigate the metabolism of Schaftoside, results showed that Schaftoside underwent poor metabolism, with only hydroxylated/methoxylated C-glycosides observed as metabolites, and no phase II conjugates containing glucuronic acid or sulfates were detectable.
Int J Mol Sci. 2021 Jun 18;22(12):6566
Schaftoside/夏佛塔苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nilaparvata lugens (brown planthopper)
2-3 instar nymphs of BPH
Artificial diet
0.05, 0.1, and 0.15 mg/mL
Diet renewed daily, duration of 15 days
To investigate the effect of Schaftoside on the survival rate of BPH, results showed that Schaftoside significantly inhibited the survival rate of BPH in a dose-dependent manner.
Front Plant Sci. 2018 May 29;9:710
Rats
Healthy rats
Intravenous injection and oral administration
1.2 mg/kg (iv), 50, 100, 200 mg/kg TFDS (po)
Single dose
To investigate the pharmacokinetics and excretion pathways of schaftoside in rats. Results showed that after intravenous injection, schaftoside was quickly eliminated from blood circulation (t1/2=0.64 h) and extensively excreted into urine (54.59 ± 9.11%) and bile (24.78 ± 3.07%) as unchanged form. After oral administration of TFDS, plasma exposure of schaftoside was dose-proportional.
Front Pharmacol. 2022 Dec 14;13:1073535
BALB/c mice
LPS-induced acute lung injury model
Intragastric administration
10 and 20 mg/kg
Single dose, lasting 8 hours
Evaluate the anti-inflammatory effect of Schaftoside, showing significant alleviation of lung inflammation and reduction of pro-inflammatory cytokine levels
Acta Pharm Sin B. 2022 Nov;12(11):4154-4164
Root-knot nematode (Meloidogyne incognita)
Root-knot nematode (Meloidogyne incognita)
Aqueous solution
114.66 μg/mL (LC50)
72 hours
To evaluate the nematicidal activity of Schaftoside against root-knot nematodes, showing an LC50 value of 114.66 μg/mL.
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