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货号 产品名 纯度
A1219082 现货 TLR7/8 Agonist 1

TLR7/8 Agonist 1 is a dual agonist of TLR7/8 with EC50 values of 50nM and 55nM, respectively. It can be used as an immune stimulator.

99%+
A1251827 现货 CU-T12-9

CU-T12-9是一种 TLR1/2 激动剂,能够激活免疫系统,对免疫治疗和疫苗研发具有潜在应用。

99%+
A1499565 现货 CU-115

CU-115 是一种高效的 TLR8 拮抗剂,IC50 为 1.04 µM,显示出对 TLR8 的高选择性(相比 TLR7,IC50 > 50 µM),并能抑制由 R-848 激活的 THP-1 细胞中 TNFIL-1β 的产生。

98%
A823597 现货 MD2-IN-1

MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2).

99%+
A846098 现货 DSR-6434

DSR 6434 is a potent TLR7 agonist with EC50 of 7.2 nM.

99%+
A154947 现货 E6446

E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

99%+
A155468 现货 CU-CPT9b

CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF-α levels.

99%+
A839990 现货 SM-324405

SM-324405 is a selective TLR7 agonist with antedrug characteristics.

98%
A611478 现货 PF-4878691

PF-4878691 is a potent and selective Toll-like receptor 7 (TLR7) agonist.

99%+
A602237 现货 Loxoribine

Loxoribine, a guanosine analog, is selective agonist of Toll-like receptor 7 with anti-viral and anti-tumor activities.

99%+
A724317 现货 Gardiquimod diTFA

Gardiquimod trifluoroacetate is a specific TLR7 agonist.

99%+
A1180468 现货 6'-Sialyllactose

6'-Sialyllactose是一种唾液酸化的低聚糖,能够促进双歧杆菌的增殖,调节肠道菌群,并抑制 TLR4 信号通路,防止坏死性小肠结肠炎的发生。

99%+
A1504220 现货 T785

T785是一种 TLR7/TLR8 双激动剂,能够激活先天免疫反应并增强肿瘤免疫。它通过诱导细胞因子和趋化因子的分泌,促进髓系细胞和 T 细胞的抗肿瘤作用。T785 主要用于合成抗体-佐剂免疫偶联物,特别是在肿瘤免疫治疗中具有潜力,帮助提高免疫检查点抑制剂的应答率和治疗效果。

95%
A1516322 现货 Enpatoran

Enpatoran(M5049)是一种有效的口服TLR7/8抑制剂,在HEK293细胞中的IC50分别为11.1 nM和24.1 nM。Enpatoran可用于与先天性和适应性自身免疫阻断相关的研究。

95%
A321163 现货 L48H37

L48H37是一种化学稳定性增强的姜黄素类似物,作为髓系分化蛋白 2 (MD2) 的有效抑制剂,能够抑制 LPS-TLR4/MD2 介导的信号通路,适用于脓毒症和肺损伤的研究。

97%
A1340564 现货 TH1020

TH1020 is Toll-like receptor (TLR) 5/Flagellin complex antagonist with IC50 of 0.85 μM. TH1020 competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

99%+
A1151906 现货 TLR7/8 agonist 1 2HCl

TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline, showing substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens

99%+
A1469763 现货 AXC-715 3HCl

AXC-715 3HCl是一种 TLR7/TLR8 双激动剂,用于合成抗体佐剂免疫偶联物,能够结合 PD-L1,增强免疫反应,适用于抗体偶联药物和免疫治疗的开发。

95%
A666696 现货 Polyinosinic-polycytidylic acid sodium/聚肌苷酸-聚胞苷酸钠盐

聚肌胞酸钠 (Poly(I)) 是一种双链 RNA 的合成类似物,作为 Toll 样受体 3 (TLR3) 和视黄酸诱导基因 I (RIG-I) 受体 (MDA5) 的激动剂。聚肌胞酸钠可作为疫苗佐剂增强先天和适应性免疫反应,改变肿瘤微环境,并直接诱导癌细胞凋亡

99% (less than 1% free nucleotides, TLC)
A388121 现货 Motolimod

Motolimod is a Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM with immunostimulatory and antineoplastic activities.

99%+
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