Rabeprazole is an antiulcer drug and selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 72 nM).
Rabeprazole/雷贝拉唑 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Dematiaceous fungi
2-128 mg/ml
72h
Rabeprazole alone exhibited limited antifungal effect against all tested species. However, the median MICs of azoles and RAB in the combination revealed up to 7.7-fold and 128-fold reduction compared to that when tested alone, respectively.
Front Cell Infect Microbiol. 2024 Jan 17;14:1296151.
Candida spp.
2-128 mg/ml
24h
Rabeprazole alone exhibited limited antifungal effect against all tested species. However, the median MICs of azoles and RAB in the combination revealed up to 7.7-fold and 128-fold reduction compared to that when tested alone, respectively.
Front Cell Infect Microbiol. 2024 Jan 17;14:1296151.
Aspergillus fumigatus
2-128 mg/ml
48h
Rabeprazole alone exhibited limited antifungal effect against all tested species. However, the median MICs of azoles and RAB in the combination revealed up to 7.7-fold and 128-fold reduction compared to that when tested alone, respectively.
Front Cell Infect Microbiol. 2024 Jan 17;14:1296151.
Trypanosoma cruzi epimastigotes
250 μM
24 hours
To evaluate the effect of Rabeprazole on cell viability and TIM enzyme activity with different numbers of parasites. Results showed that Rabeprazole significantly reduced cell viability and TIM enzyme activity.
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2231169.
Trypanosoma cruzi epimastigotes
100–2000 μM
4 hours
To evaluate the effect of Rabeprazole on cell viability and TIM enzyme activity. Results showed that Rabeprazole significantly reduced cell viability and TIM enzyme activity.
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2231169.
Campylobacter jejuni and C. coli
16 µg/ml
Immediately
RPZ-TH and PPIs also inhibited the motility of C. jejuni and C. coli, but had no effect on other bacteria such as V. cholerae and S. enterica.
Rabeprazole (RPZ) and its thioether derivative (RPZ-TH) markedly inhibited the motility of H. pylori. RPZ-TH completely blocked motility at 1 µg/ml, while RPZ had an IC50 of 16 µg/ml.
Human lung microvascular endothelial cells (HLMVECs)
20 μM
18 hours
Rabeprazole induced HIF1A mRNA expression in a dose-dependent manner
Cells. 2022 Apr 22;11(9):1425.
Trypanosoma cruzi epimastigotes
1 mM
4 hours
To evaluate the effect of Rabeprazole on cell viability and TIM enzyme activity with different numbers of parasites in a short time. Results showed that Rabeprazole significantly reduced cell viability and TIM enzyme activity.
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2231169.
Human lung microvascular endothelial cells (HLMVECs)
20 μM
18 hours
Rabeprazole induced HIF1A mRNA expression in a dose-dependent manner
Cells. 2022 Apr 22;11(9):1425.
HEK293 cells
100 μM
48 hours
Rabeprazole significantly reduced the transcriptional activity of the CDX2 promoter.
Front Pharmacol. 2024 Nov 7;15:1409001.
AGS cells
100 μM
48 hours
Rabeprazole significantly downregulated CDX2 and MUC2 mRNA and protein levels, alleviating gastric intestinal metaplasia.
Front Pharmacol. 2024 Nov 7;15:1409001.
BGC823 cells
100 μM
48 hours
Rabeprazole inhibited CREB phosphorylation and nuclear translocation, reducing the binding of CREB to the GPX4 promoter, thereby decreasing GPX4 expression and inducing ferroptosis.
Front Pharmacol. 2024 Nov 7;15:1409001.
Rabeprazole/雷贝拉唑 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
B10.RIII mice
Experimental autoimmune uveitis (EAU) model
Intraperitoneal injection
60 mg/kg/day
Once daily for 7 days (from Day 7 to Day 14)
To evaluate the effect of rabeprazole on the EAU mouse model. Results showed that rabeprazole reduced anterior chamber inflammation and retinal inflammation, inhibited TNF and IL-1β expression, and promoted IL-10 expression.
Front Immunol. 2022 Jun 21;13:895869
C57BL/6 mice
DNBS and DSS-induced colitis models
Oral
30 mg/kg
Twice daily, throughout the experiment
Rabeprazole failed to demonstrate any anti-colitic effect
Front Immunol. 2022 May 25;13:870817
Mice
Endotoxemia-induced inflammatory lung injury model
Oral
18 mg/kg
Administered at 4 and 20 hours post-LPS
Rabeprazole promotes vascular repair and resolution of inflammatory lung injury through HIF-1α/FoxM1 signaling
Cells. 2022 Apr 22;11(9):1425.
Wistar rats
Anesthetized rat model
Intravenous injection
4 mg/kg
Single dose, lasting 2 hours
To investigate the effects of Rabeprazole on the concentration of amoxicillin in gastric juice and gastric mucosa. Results showed that Rabeprazole increased the amoxicillin concentration in gastric juice but did not significantly alter its concentration in blood or gastric mucosa.
Acta Pharmacol Sin. 2010 Apr;31(4):501-8
Female Swiss albino mice
Osteoporosis model
Oral
10 mg/kg every 48 hours
Every 48 hours for 18 weeks
To investigate the impact of rabeprazole on osteoporosis and explore the modulatory effects of dietary calcium or alendronate on this side effect. Results showed that rabeprazole significantly reduced bone mineral density, increased trabecular separation and osteoclast number. Calcium supplementation or alendronate partially restored bone density and reduced osteoclast activity.
Hong Kong
... 展开 >> Prince of Wales Hospital
Hong Kong, Hong Kong
Japan
Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan
Izumo, Japan
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Kyoto, Japan
Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan (Satellite hospital of Osaka City University)
Osaka, Japan
Department of Gastroenterology, Osaka City University Graduate School of Medicine
Osaka, Japan
Department of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, Japan (Satellite hospital of Osaka City University)
Osaka, Japan
Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
Osaka, Japan
Department of Internal Medicine and Gastroenterology, Saga Medical School, Saga, Japan
Saga, Japan 收起 <<
Hong Kong
... 展开 >> Prince of Wales Hospital
Hong Kong, Hong Kong
Japan
Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan
Izumo, Japan
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Kyoto, Japan
Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan (Satellite hospital of Osaka City University)
Osaka, Japan
Department of Gastroenterology, Osaka City University Graduate School of Medicine
Osaka, Japan
Department of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, Japan (Satellite hospital of Osaka City University)
Osaka, Japan
Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
Osaka, Japan
Department of Internal Medicine and Gastroenterology, Saga Medical School, Saga, Japan
Saga, Japan 收起 <<
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Nagoya, Aichi, Japan
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... 展开 >>
MRA Clinical Research - Phase 1
Miami, Florida, United States, 33143
Miami Research Associates, LLC
South Miami, Florida, United States, 33143
MRA Clinical Research, LLC
South Miami, Florida, United States, 33143 收起 <<
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... 展开 >>
ASTHMA, Inc.
Richland, Washington, United States, 99352
ASTHMA, Inc.
Seattle, Washington, United States, 98105 收起 <<
Japan
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Kariya, Aichi, Japan
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