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首页 / 抑制剂/激动剂 / 膜转运蛋白 / 质子泵 / Pantoprazole sodium/泮托拉唑钠

Pantoprazole sodium/泮托拉唑钠 {[allProObj[0].p_purity_real_show]}

货号：A261610 同义名： 泮托拉唑钠盐 / SKF96022 sodium; BY1023 sodium

Pantoprazole sodium是一种质子泵抑制剂，可以抑制 H+/K+ ATP 酶的功能，常用于研究过度酸症。

Pantoprazole sodium/泮托拉唑钠 化学结构 CAS号：138786-67-1
Pantoprazole sodium/泮托拉唑钠 化学结构
CAS号：138786-67-1
Pantoprazole sodium/泮托拉唑钠 3D分子结构
CAS号：138786-67-1
Pantoprazole sodium/泮托拉唑钠 化学结构 CAS号：138786-67-1
Pantoprazole sodium/泮托拉唑钠 3D分子结构 CAS号：138786-67-1
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Pantoprazole sodium/泮托拉唑钠 纯度/质量文件 产品仅供科研

货号：A261610 标准纯度： {[allProObj[0].p_purity_real_show]}
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产品名称 Proton Pump ↓ 其他靶点 纯度
Zinc pyrithione ✔ 98+%
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

 		99%
Lansoprazole ✔ 98%
Esomeprazole Magnesium ✔ 98%+
Rabeprazole ✔ 99%+
Ilaprazole ✔ TOPK 97%
Bafilomycin A1 ++++

H+-ATPase, IC50: 0.44 nM

 		99%
Pantoprazole sodium ✔ 98%
(R)-Lansoprazole ✔ 98%
Tenatoprazole ✔ 99%+
Omeprazole ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Pantoprazole sodium/泮托拉唑钠 生物活性

靶点

  • Proton Pump
描述 Pantoprazole sodium is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM[3]. Pantoprazole (>200 μmol/L) increased endosomal pH in cells, and also increased nuclear uptake of doxorubicin. Pretreatment with pantoprazole increased tissue penetration of doxorubicin in MCCs(multilayered cell cultures). Pantoprazole improved doxorubicin distribution from blood vessels in solid tumors. Pantoprazole given before doxorubicin led to increased growth delay when given as single or multiple doses to mice bearing MCF7 xenografts[4]. Pantoprazole also has various off-label uses, including eradicating Helicobacter pylori bacteria and preventing peptic ulcer re-bleeding and/or NSAID-induced ulcers[5]. Pantoprazole sodium (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats. Pantoprazole exhibited both anti-ulcer and healing promoting effects on duodenal ulcers in rats[6].

Pantoprazole sodium/泮托拉唑钠 细胞实验

Cell Line
Concentration Treated Time Description References
U87 human GBM cells 100-900 µM 12 hours and 24 hours To evaluate the effect of PPZ on glioma cell growth, results showed that PPZ significantly inhibited cell viability in a dose- and time-dependent manner. Cell Mol Neurobiol. 2018 Nov;38(8):1491-1504.
C6 rat glioma cells 100-900 µM 12 hours and 24 hours To evaluate the effect of PPZ on glioma cell growth, results showed that PPZ significantly inhibited cell viability in a dose- and time-dependent manner. Cell Mol Neurobiol. 2018 Nov;38(8):1491-1504.
Klebsiella pneumoniae 2 mg/mL 30 minutes To evaluate the inhibitory effect of pantoprazole on the hydrolytic activity of metallo-β-lactamases. Results showed that pantoprazole significantly inhibited the hydrolytic activity of metallo-β-lactamases, with higher inhibition effects compared to captopril. Front Pharmacol. 2024 Mar 12;15:1366459.
Human osteoclasts 0.1-10 μg/mL 7 days To evaluate the effects of pantoprazole on the viability and function of human osteoclasts. Results showed that pantoprazole significantly decreased osteoclast viability and TRAP activity. Mediators Inflamm. 2015;2015:413097.

Pantoprazole sodium/泮托拉唑钠 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
CD-1 mice Femur fracture model Intraperitoneal injection 100 mg/kg Daily for 2 weeks or 5 weeks To study the effect of pantoprazole on fracture healing in aged mice. Results showed that pantoprazole impairs fracture healing in aged mice by affecting angiogenic and osteogenic growth factor expression, osteoclast activity and bone formation. Sci Rep. 2020 Dec 23;10(1):22376
C57BL/6J mice Chronic proton pump inhibitor use model Gavage 150 mg/kg Three times a week for 60 days To investigate the effects of pantoprazole on gut microbiota, intestinal barrier integrity, TLR4 signaling, and liver fibrosis. Results showed that pantoprazole altered microbiota composition, increased circulating LPS levels, activated hepatic TLR4 signaling, and led to liver microvesicular steatosis and fibrosis. Int J Mol Sci. 2022 Nov 9;23(22):13766
Wistar albino rats Renal ischemia/reperfusion injury model Intraperitoneal injection 160 mg/kg Single dose Pantoprazole attenuated renal IRI by suppressing apoptosis, attenuating pro-inflammatory cytokines levels, and inhibiting the intracellular signaling pathway MAPK (ERK1/2, JNK, p38)–NF-κB. Int J Mol Sci. 2021 Oct 1;22(19):10669
Wistar albino rats Renal ischemia/reperfusion injury model Oral 40 mg/kg Twice daily for 10 days To evaluate the protective effect of Pantoprazole sodium in renal ischemia/reperfusion injury, results showed it significantly reduced serum creatinine, BUN, and MDA levels, and inhibited inflammatory cytokines and apoptosis signaling pathways Molecules. 2022 Feb 18;27(4):1383
Wistar albino rats Renal ischemia/reperfusion injury model Oral administration 40 mg/kg Twice daily for ten days Pantoprazole attenuated renal IRI by suppressing apoptosis, attenuating pro-inflammatory cytokines levels, and inhibiting the intracellular signaling pathway MAPK (ERK1/2, JNK, p38)–NF-κB. Int J Mol Sci. 2021 Oct 1;22(19):10669

Pantoprazole sodium/泮托拉唑钠 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02170896 Healthy Phase 1 Completed - -
NCT03545243 Dysbiosis Phase 4 Recruiting March 8, 2021 Belgium ... 展开 >> UZ Leuven Recruiting Leuven, Belgium, 3000 Contact: Lucas Wauters, MD    003216342538    lucas.wauters@kuleuven.be 收起 <<
NCT00681005 GERD Not Applicable Completed - -

Pantoprazole sodium/泮托拉唑钠 参考文献

[1]Shen Y, Chen M, et al. Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2. Oncol Lett. 2016 Jan;11(1):717-722.

[2]Shen Y, Wu Y, et al. Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells. Neoplasma. 2012;59(2):142-9.

[3]Beil W, Staar U, Sewing KF. Pantoprazole: a novel H+/K(+)-ATPase inhibitor with an improved pH stability. Eur J Pharmacol. 1992 Aug 6;218(2-3):265-71

[4]Patel KJ, Lee C, Tan Q, Tannock IF. Use of the proton pump inhibitor pantoprazole to modify the distribution and activity of doxorubicin: a potential strategy to improve the therapy of solid tumors. Clin Cancer Res. 2013 Dec 15;19(24):6766-76

[5]Bernshteyn MA, Masood U. Pantoprazole. 2021 Jul 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–

[6]Takeuchi K, Konaka A, Nishijima M, Kato S, Yasuhiro T. Effects of pantoprazole, a novel H+/K+-ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: a comparative study with omeprazole and lansoprazole. J Gastroenterol Hepatol. 1999 Mar;14(3):251-7

Pantoprazole sodium/泮托拉唑钠 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.34mL

2.47mL

1.23mL

24.67mL

4.93mL

2.47mL

Pantoprazole sodium/泮托拉唑钠 技术信息

CAS号138786-67-1
分子式C16H14F2N3NaO4S
分子量 405.35
SMILES Code COC1=CC=NC(CS(C2=NC3=C([N-]2)C=CC(OC(F)F)=C3)=O)=C1OC.[Na+]
MDL No. MFCD01658543
别名 泮托拉唑钠盐 ;SKF96022 sodium; BY1023 sodium; SKF-96022; SK and F 96022; Protonix; Zurcal; Pantecta; Controloc; Pantoloc
运输蓝冰
InChI Key YNWDKZIIWCEDEE-UHFFFAOYSA-N
Pubchem ID 15008962
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(259.03 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 3 mg/mL(7.4 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Pantoprazole | 138786-67-1 | BY1023 | SKF96022 | BY 1023 | BY-1023 | SKF 96022 | SKF-96022 | Proton Pump Inhibitor | Membrane Transporter/Ion Channel | Autophagy | Apoptosis | Anti-infection | Proton Pump | Autophagy | Apoptosis | Bacterial | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Pantoprazole sodium/泮托拉唑钠 纯度/质量文件 | Pantoprazole sodium/泮托拉唑钠 亚型比较 | Pantoprazole sodium/泮托拉唑钠 生物活性 | Pantoprazole sodium/泮托拉唑钠 临床数据 | Pantoprazole sodium/泮托拉唑钠 参考文献 | Pantoprazole sodium/泮托拉唑钠 实验方案 | Pantoprazole sodium/泮托拉唑钠 技术信息

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