Quercetin Dihydrate

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Chemical Structure| 6151-25-3 同义名 : 槲皮素,二水 ;Sophoretin
CAS号 : 6151-25-3
货号 : A114540
分子式 : C15H14O9
纯度 : 95%
分子量 : 338.27
MDL号 : MFCD00149487
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(310.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • p110γ

    PI3Kγ, IC50:2.4 μM

  • p110β

    PI3Kβ, IC50:5.4 μM

  • p110δ

    PI3Kδ, IC50:3.0 μM

  • SIRT1
描述 Quercetin is a natural flavonoid that can activate SIRT1, inhibit PI3K, inhibit PI3K γ, PI3K δ, PI3K β, with IC50[3]. In vitro，the IC50[4]. In vivo， combination of quercetin and 2-ME can serve as a novel clinical treatment regimen owning the potential of enhancing antitumor effect on prostate cancer and lessening the dose and side effects of either quercetin or 2-ME alone[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01881919 Hyperuricemia ... 展开 >> Gout Kidney Calculi Diabetes Cardiovascular Disease 收起 << Early Phase 1 Completed - United Kingdom ... 展开 >> School of Food Science and Nutrition Leeds, West Yorkshire, United Kingdom, LS2 9JT 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.78mL

2.96mL

1.48mL

29.56mL

5.91mL

2.96mL
参考文献

[1]Dajas F. Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol. 2012 Sep 28;143(2):383-96.

[2]Sing SE, Peterson RK. Assessing environmental risks for established invasive weeds: Dalmatian (Linaria dalmatica) and yellow (L. vulgaris) toadflax in North America. Int J Environ Res Public Health. 2011 Jul;8(7):2828-53.

[3]Navarro-Núñez L, Lozano ML, Martínez C, Vicente V, Rivera J. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. doi: 10.1016/j.fitote.2009.08.006. Epub 2009 Aug 15. PMID: 19686810.

[4]Yu XB, Liu XJ, Qian DH, Zhang JP, Hu ZL, Wu TM. [Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries]. Yao Xue Xue Bao. 1996;31(3):176-81. Chinese. PMID: 9206266.

[5]Yang F, Song L, Wang H, Wang J, Xu Z, Xing N. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277. doi: 10.1371/journal.pone.0128277. PMID: 26011145; PMCID: PMC4444352.