Forsythoside B is a natural product isolated and purified from the fruits of Forsythia suspensa which inhibits inflammatory response,and has antioxidant properties with potent neuroprotective effects with a favorable therapeutic time-window, reduce of cerebral ischemia and reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown, and can rescue cardiac function from I/R injury. Forsythoside B has antisepsis effect, is mediated by decreasing local and systemic levels of a wide spectrum of inflammatory mediators. Its antisepsis mechanism may be that Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activition.
Forsythoside B/连翘酯苷B 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Mouse primary cortical neurons
0.1, 1, 10 μmol/L
24 hours
To evaluate the protective effect of Forsythoside B on oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury. Results showed that Forsythoside B significantly increased the viability of neurons after OGD/R treatment.
Acta Pharm Sin B. 2022 May;12(5):2330-2347.
BV-2 cells
1μM and 2.5μM
3 hours
FTS B significantly suppressed the release of IL-6, TNF-α, iNOs, NO, and IL-1β in LPS-induced BV-2 cells.
J Neuroinflammation. 2020 Oct 15;17(1):305.
Bovine Serum Albumin (BSA)
0— 3.5×10^−5 M
Investigation of the interaction between Forsythoside B and BSA, showing that the quenching mechanism is a combination of static quenching and non-radiative energy transfer.
J Pharm Anal. 2013 Feb;3(1):61-65.
Forsythoside B/连翘酯苷B 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
APP/PS1 transgenic mice
Alzheimer's disease model
Intragastric administration
10 mg/kg and 40 mg/kg
Once daily for 36 days
FTS B improved cognitive function, reduced Aβ deposition and tau protein phosphorylation, and inhibited the activation of microglia and astrocytes in APP/PS1 mice.
J Neuroinflammation. 2020 Oct 15;17(1):305.
KM mice
Transient middle cerebral artery occlusion (tMCAO) model
Intravenous injection
10, 20, 40 mg/kg
Single dose at the beginning of reperfusion
To evaluate the protective effect of Forsythoside B on cerebral ischemia/reperfusion injury. Results showed that Forsythoside B significantly reduced infarct volume and neurological deficit scores.
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