QNZ（EVP4593）对NF-κB转录激活和TNF-α生成具有强效抑制作用，IC50值分别为11 nM和7 nM。QNZ（EVP4593）是一种神经保护性的SOC通道抑制剂。

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Bioymifi is an activatior of the TRAIL receptor DR5 in cancer cells.

Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity and inhibits angiogenesis and reduces the secretion of TNF alpha.

VGX-1027 is an orally active immunomodulatory agent that primarily targets macrophages, it can inhibit TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. VGX-1027 also reduces the secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ.

Nedocromil Sodium is a potent TNF-α inhibitor with an IC50 value of 1.67 μM for Blood eosinophils.

GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.

R-7050 is an antagonist of tumor necrosis factor receptor (TNFR) that towards TNFα.

(Rac)-Shikonin是一种天然产物，具有强效的抗肿瘤活性，能够绕过癌症耐药性。

Forsythoside B 是从传统中药植物连翘（Forsythia suspensa）叶中分离出来的苯乙烯苷类物质，可用于研究炎症性疾病和促进血液循环。Forsythoside B 抑制 TNF-alpha、IL-6、IκB 并调节 NF-κB。

(Rac)-Benpyrine is the racemate form of Benpyrine. Benpyrine could directly bind to TNF-α and block TNF-α-trigged signaling activation in vitro and in vivo. Administration of benpyrine by gavage significantly relieved the symptoms of collagen-induced arthritis and imiquimod-induced psoriasiform inflammation in mice.

PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models.

Adalimumab是一种人源化IgG1单克隆抗体，通过与TNFα结合来阻止其与受体结合。Adalimumab具有用于类风湿性关节炎、克罗恩病和牛皮癣研究的潜力。

Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM.

Geraniin is a naturally occuring dehydroellagitannin found in geraniums which can mediates apoptosis.

Homoplantaginin, a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway.

Pomalidomide是一种第三代免疫调节剂，通过与 E3 连接酶 cereblon 相互作用并诱导必需的 Ikaros 转录因子降解，作为分子胶作用。

Infliximab是一种嵌合IgG1单克隆抗体，通过与TNFα结合来阻止其与受体结合。Infliximab具有用于类风湿性关节炎、克罗恩病和溃疡性结肠炎研究的潜力。

Thalidomide targets to CRBN with IC50 of 8.5 nM. It can inhibit biosynthesis of TNF-α and has anti-angiogenic and immunosuppressive effects.