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货号 产品名 纯度
A230954 现货 QNZ

QNZ(EVP4593)对NF-κB转录激活和TNF生成具有强效抑制作用,IC50值分别为11 nM和7 nM。QNZ(EVP4593)是一种神经保护性的SOC通道抑制剂。

99%+
A542297 现货 Forsythoside B/连翘酯苷B

Forsythoside B 是从传统中药植物连翘(Forsythia suspensa)叶中分离出来的苯乙烯苷类物质,可用于研究炎症性疾病和促进血液循环。Forsythoside B 抑制 TNF-alphaIL-6、IκB 并调节 NF-κB

99%+
A203253 现货 Pomalidomide/泊马度胺

Pomalidomide是一种第三代免疫调节剂,通过与 E3 连接酶 cereblon 相互作用并诱导必需的 Ikaros 转录因子降解,作为分子胶作用。

98%
A466111 现货 Necrostatin 2 racemate

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

99%+
A809531 现货 Roquinimex/利诺安

Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity and inhibits angiogenesis and reduces the secretion of TNF alpha.

99%+
A590582 现货 VGX-1027

VGX-1027 is an orally active immunomodulatory agent that primarily targets macrophages, it can inhibit TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. VGX-1027 also reduces the secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ.

99%+
A716229 现货 Nedocromil sodium

Nedocromil Sodium is a potent TNF-α inhibitor with an IC50 value of 1.67 μM for Blood eosinophils.

97%
A135126 现货 GSK481

GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.

99%+
A386124 现货 R-7050

R-7050 is an antagonist of tumor necrosis factor receptor (TNFR) that towards TNFα.

97%
A288138 现货 (Rac)-Shikonin/莽草素

99%
A310971 现货 Homoplantaginin/高车前苷

Homoplantaginin, a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway.

98%
A1352250 现货 (Rac)-Benpyrine

(Rac)-Benpyrine is the racemate form of Benpyrine. Benpyrine could directly bind to TNF-α and block TNF-α-trigged signaling activation in vitro and in vivo. Administration of benpyrine by gavage significantly relieved the symptoms of collagen-induced arthritis and imiquimod-induced psoriasiform inflammation in mice.

97%
A633788 现货 PF-3644022

PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models.

99%+
A1174420 现货 Adalimumab/阿达木单抗

Adalimumab是一种人源化IgG1单克隆抗体,通过与TNFα结合来阻止其与受体结合。Adalimumab具有用于类风湿性关节炎、克罗恩病和牛皮癣研究的潜力。

95%
A164079 现货 Thalidomide/沙利度胺

Thalidomide targets to CRBN with IC50 of 8.5 nM. It can inhibit biosynthesis of TNF-α and has anti-angiogenic and immunosuppressive effects.

98%
A368764 现货 Lenalidomide/来那度胺

Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM.

98%
A447714 现货 Geraniin/老鹳草素

Geraniin is a naturally occuring dehydroellagitannin found in geraniums which can mediates apoptosis.

99%+
A1482574 AN0128

95%
A130673 Bioymifi

Bioymifi is an activatior of the TRAIL receptor DR5 in cancer cells.

98%
A320400 Pimaric acid/海松酸

Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells.

98+%
产品名 TNF-α 其他靶点 纯度
Thalidomide E3 Ligase 98%
GSK2982772 ++

human RIP1, IC50: 16 nM

99%+
QNZ ++++

TNF-α, IC50: 7 nM

NF-κB 99%+
Lenalidomide +++

TNF-α, IC50: 13 nM

98%
Pomalidomide +++

TNF-α, IC50: 13 nM

98%
GSK481 99%+
Apremilast ++

TNF-α, IC50: 77 nM

98%
Necrostatin-1 +

RIP1, EC50: 490 nM

99%+
N-Ac-Cys-OH 98%
Adalimumab 95%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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