Dauricine, a bisbenzylisoquinoline alkaloid derived from Menispermum dauricum, exhibits anti-inflammatory properties. It hampers cell proliferation and invasion and prompts apoptosis by inhibiting NF-κB activation in a dose- and time-dependent manner in colon cancer[1].
体内研究
Dauricine, when administered subcutaneously at 40 mg/kg every two days for nine days, inhibits the growth of colonic tumors in a HCT116 xenograft mouse model[1].
Dauricine, given intraperitoneally at 1 or 10 mg/kg, mitigates cognitive impairment, diminishes Aβ accumulation, and curtails Tau hyperphosphorylation in 3xTg-Alzheimer's Disease mice[2].
体外研究
Dauricine, at concentrations ranging from 0 to 20 μM over a period of 8 days, suppresses the growth of HCT116, HCT8, SW620, and SW480 cells[1].
Dauricine, at concentrations from 0 to 20 μM, induces G1 phase cell-cycle arrest in HCT116 cells after 12 and 24 hours of treatment[1].
Dauricine, in concentrations ranging from 0 to 20 μM over a period of 36 hours, induces apoptosis in HCT116 cells and inhibits their invasion[1].
Dauricine, administered at 0-20 μM for 6 hours, suppresses the activation of the NF-κB signaling pathway in HCT116 cells[1].
Dauricine (1 and 2 μg/mL, 24 h) inhibits glucose glycolysis and increased oxidative phosphorylation in HepG2 and Huh-7 cells[3].
Dauricine (2 μg/mL, 48 h) increases the sensitivities of HCC cell lines to both Cisplatin and Sorafenib[3].
Dauricine/蝙蝠葛碱 细胞实验
Cell Line
Concentration
Treated Time
Description
References
A549 cells
5 and 15 µM
24 h
To evaluate the effect of Dauricine on the proliferation of lung adenocarcinoma cells, results showed significant reduction in cell proliferation
Cells. 2025 May 12;14(10):698
SH-SY5Y neuroblastoma cells
1 μM
24 h
Evaluate the neuroprotective effects of DPM against Fe2+-induced toxicity, DPM significantly increased cell viability
J Nanobiotechnology. 2020 Apr 19;18(1):61
Dauricine/蝙蝠葛碱 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Subcutaneous cell line-derived syngeneic model
Intraperitoneal injection
20 mg/kg
Once daily for 21 days
To evaluate the inhibitory effect of Dauricine on lung adenocarcinoma tumor growth in vivo, results showed significant inhibition of tumor growth
Cells. 2025 May 12;14(10):698
Mice
3xTg-AD mouse model
Intraperitoneal injection
1 or 10 mg/kg
Once daily for 2 months
DAU significantly improved cognitive impairments in 3xTg-AD mice by decreasing Aβ plaques and hyperphosphorylated tau and increasing the hippocampal ATP level.
Front Cell Dev Biol. 2021 Feb 5;8:624339
C57BL/6 mice
Autologous whole blood double infusion ICH model
Tail vein injection
100 mg/kg DPM (equivalent to 10.1 mg/kg DRC)
Administered immediately after ICH surgery, evaluated at 24 h
Assess the improvement of DPM on neurological deficits, brain edema, and BBB permeability post-ICH, DPM significantly improved neurological scores, reduced brain water content and Evans blue leakage
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