CNDAC HCl | CNDAC hydrochloride | Nucleoside Analog | AmBeed-信号通路专用抑制剂

首页 / / / / CNDAC HCl

CNDAC HCl {[allProObj[0].p_purity_real_show]}

货号：A631239 同义名： CNDAC hydrochloride

CNDAC HCl是口服药物 Sapacitabine 的代谢物，属于核苷酸类似物，可诱导 DNA 损伤和细胞凋亡。

CNDAC HCl 化学结构
CAS号：134665-72-8

CNDAC HCl 3D分子结构
CAS号：134665-72-8

规格	价格	会员价	库存	数量
{[ item.pr_size ]} {[ size_append(item.pr_size_append, item.pr_am, item.pr_size) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]}	现货	1周咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

CNDAC HCl 纯度/质量文件产品仅供科研

货号：A631239 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025, 188, (21): 5847-5861.e11. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025, 20, 1502-1513. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

DNA 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							98%
Daptomycin	✔							98%
Blasticidin S·HCl	✔							98%
Metronidazole	✔							98%
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Oxolinic acid	✔							98+%
Bendamustine	✔							98+%
Trifluridine	✔							98%
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							98%
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							98%
YK-4-279		✔						99%+
ML216		+ BLM^full-length, IC50: 2.98 μM BLM^636-1298, IC50: 0.97 μM						99%+
RK-33		✔						98%
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					99%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				97%
Didox				✔				98%
(E)-3-AP				✔				99%
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, IC50: 46.11 nM Leucyl-tRNA synthetase, Kd: 42.1 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

CNDAC HCl 生物活性

描述

CNDAC hydrochloride, a metabolite of the orally active agent Sapacitabine, acts as a nucleoside analog that prompts DNA damage and apoptosis^[1].^[2].

体外研究

CNDAC employs a distinctive mechanism by inducing single-strand breaks (SSBs) in DNA, which transform into double-strand breaks (DSBs) during a subsequent S phase, highlighting its unique action mode^[1].

Sensitivity to CNDAC is increased in cells lacking Rad51D and XRCC3, with exposure ranges from 0 to 1 μM for 24 hours^[1].

Moreover, CNDAC inhibits the proliferation of HL-60 and THP-1 cells at concentrations from 0 to 100 μM over 3 days and induces apoptosis in these cell lines at 0 to 10 μM over 3 to 6 days^[2].

Otherwise, at the concentration of 6 μM for 48 h, CNDAC induces cell cycle arrest in the G2 phase following a delayed S phase in HCT116 cells^[3].

CNDAC HCl 参考文献

[1]Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. 2012 Aug;31(8):373-80.

[2]Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683.

[3]Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36.

CNDAC HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.46mL

0.69mL

0.35mL

17.32mL

3.46mL

1.73mL

34.64mL

6.93mL

3.46mL

CNDAC HCl 技术信息

CAS号	134665-72-8
分子式	C₁₀H₁₃ClN₄O₄
分子量	288.69
SMILES Code	N#C[C@@H]1[C@H](N2C=CC(N)=NC2=O)O[C@H](CO)[C@H]1O.[H]Cl
MDL No.	MFCD32201159

别名	CNDAC hydrochloride
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 120 mg/mL(415.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

CNDAC HCl {[allProObj[0].p_purity_real_show]}

CNDAC HCl 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

CNDAC HCl 质控信息

CNDAC HCl 生物活性

CNDAC HCl 参考文献

CNDAC HCl 实验方案

CNDAC HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

CNDAC HCl {[allProObj[0].p_purity_real_show]}

CNDAC HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

CNDAC HCl 质控信息

CNDAC HCl 生物活性

CNDAC HCl 参考文献

CNDAC HCl 实验方案

CNDAC HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

CNDAC HCl 纯度/质量文件产品仅供科研