CNDAC HCl

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Chemical Structure| 134665-72-8 同义名 : CNDAC hydrochloride
CAS号 : 134665-72-8
货号 : A631239
分子式 : C10H13ClN4O4
纯度 : 99%+
分子量 : 288.69
MDL号 : MFCD32201159
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(415.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 CNDAC hydrochloride, a metabolite of the orally active agent Sapacitabine, acts as a nucleoside analog that prompts DNA damage and apoptosis[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.46mL

0.69mL

0.35mL

17.32mL

3.46mL

1.73mL

34.64mL

6.93mL

3.46mL
参考文献

[1]Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. 2012 Aug;31(8):373-80.

[2]Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683.

[3]Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36.