货号:A103354
                
                同义名:
                    
                        
                            6-姜辣素
                            
                             / (S)-(+)-[6]Gingerol; [6]-Gingerol
                            
                        
                    
                
                
                
                    
                    
                    
                    
                
            
6-Gingerol是瞬时受体电位香草受体 1(TRPV1)和瞬时受体电位肌球蛋白受体 A1(TRPA1)的激动剂,其 EC50 值分别为 3.3 µM 和 10.4 µM,是生姜根茎中的天然化学物质。
 HazMat Fee + There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
| Type | HazMat fee for 500 gram (Estimated) | 
| Excepted Quantity | USD 0.00 | 
| Limited Quantity | USD 15-60 | 
| Inaccessible (Haz class 6.1), Domestic | USD 80+ | 
| Inaccessible (Haz class 6.1), International | USD 150+ | 
| Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ | 
| Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ | 
                                
                                
                            

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|---|---|---|---|---|---|---|---|
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免费溶解
                        
                    
| 产品名称 | AMPK ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WZ4003 | 
                                                
                                                    ++++
                                                    
                                                    
                                                     NUAK1, IC50: 20 nM NUAK2, IC50: 100 nM  | 
                                            
                                        
                                        98+% | |||||||||||||||||
| Dorsomorphin | 
                                                
                                                    ++
                                                    
                                                    
                                                     AMPK, Ki: 109 nM  | 
                                            
                                        
                                        99% | |||||||||||||||||
| HTH-01-015 | 
                                                
                                                    +++
                                                    
                                                    
                                                     NUAK1 , IC50: 100 nM  | 
                                            
                                        
                                        99%+ | |||||||||||||||||
| 1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 | |||||||||||||||||||
| 描述 | 6-Gingerol, a pungent oil of fresh ginger, reduces biofilm formation and virulence by antagonistically binding to P. aeruginosa QS receptors. The height of the biofilm formed with 10 μM and 0 μM 6-gingerol was ~12 and ~25 μm, respectively. The growth of Pseudomonas aeruginosa was slightly inhibited by 0.1-100 μ m 6-gingerol[3]. Moreover,6-gingerol exhibited protective effects on apoptosis induced by Aβ1–42 in cultured PC12 cells by reducing oxidative stress and inflammatory responses, suppressing the activation of GSK-3β and enhancing the activation of Akt[4]. | 
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 | 
| NCT03268655 | Colorectal Adenoma | Not Applicable | Not yet recruiting | February 2020 | United States, Minnesota ... 展开 >> Epidemiology Clinical Research Center Minneapolis, Minnesota, United States, 55415 收起 << | 
| NCT03089593 | Healthy Volunteers | Not Applicable | Completed | - | Brazil ... 展开 >> Hospital das Clínicas Belo Horizonte, Minas Gerais, Brazil, 30130-100 收起 << | 
| NCT03028454 | Muscle Soreness | Not Applicable | Completed | - | United States, Virginia ... 展开 >> Human Performance Laboratory Norfolk, Virginia, United States, 23529 收起 << | 
| 计算器 | ||||
| 存储液制备 | ![]()  | 
                        1mg | 5mg | 10mg | 
| 
                             1 mM 5 mM 10 mM  | 
                        
                             3.40mL 0.68mL 0.34mL  | 
                        
                             16.98mL 3.40mL 1.70mL  | 
                        
                             33.97mL 6.79mL 3.40mL  | 
                    |
| CAS号 | 23513-14-6 | 
| 分子式 | C17H26O4 | 
| 分子量 | 294.39 | 
| SMILES Code | CCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O | 
| MDL No. | MFCD00210507 | 
| 别名 | 6-姜辣素 ;(S)-(+)-[6]Gingerol; [6]-Gingerol | 
| 运输 | 蓝冰 | 
| InChI Key | NLDDIKRKFXEWBK-AWEZNQCLSA-N | 
| Pubchem ID | 442793 | 
| 存储条件 | 
                                
                                    
                                             In solvent -20°C:3-6个月-80°C:12个月  | 
                        
| 溶解方案 | 
                                
                                    
                                     DMSO: 50 mg/mL(169.85 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶 
 
 
 
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