7-Methoxyisoflavone, an isoflavone derivative, is activator of adenosine monophosphate-activated protein kinase (AMPK).

Ginkgolide C can enhance the cardiac function of rats in the body, is a flavone isolated from Ginkgo biloba leaves.

MARK-IN-4是一种有效的微管亲和调节激酶 (MARK) 抑制剂，IC₅₀ 为 1 nM。通过抑制 MARK，MARK-IN-4 能够潜在阻止阿尔茨海默病中神经原纤维缠结的形成，适用于神经退行性疾病的研究。

BAY-3827是一种 AMPK 抑制剂，能够影响能量代谢，并在代谢疾病及癌症研究中具有潜在的应用价值。

Vaccarin 是一种具有多种生物功能的活性黄酮苷。Vaccarin 显著促进伤口愈合及伤口处内皮细胞和成纤维细胞的增殖。Vaccarin 通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。

Marein是一种通过激活 CaMKK/AMPK/GLUT1 信号通路促进葡萄糖摄取的神经保护剂，同时能够通过 IRS/Akt/GSK-3β 通路增加糖原合成，改善胰岛素抵抗，并通过 AMPK 信号通路减少线粒体功能损伤，具有抗氧化、抗糖尿病等多重生物活性。

AMPK-IN-3是一种选择性的 AMPK 抑制剂，IC₅₀ 分别为 60.7 nM 和 107 nM，对 KDR 的抑制较弱。AMPK-IN-3 可用于研究癌症中的能量代谢途径，而不会引发明显的细胞毒性。

PF-06685249是一种高效、口服活性的变构 AMPK 激活剂，EC₅₀ 为 12 nM。该化合物广泛用于糖尿病肾病的研究，能够通过调节细胞代谢途径，改善代谢紊乱相关疾病。

Lixumistat acetate是二甲双胍的衍生物，是一种强效的，具有口服活性的 AMPK 激活剂。可以缓解与年龄相关的认知障碍，并作为一种有效的氧化磷酸化(OXPHOS)抑制剂，适用于实体肿瘤研究。

Buformin hydrochloride (1-Butylbiguanide hydrochloride)是一种有效的 AMPK 激活剂和口服活性的双胍类降糖药，具有抗癌活性，可用于宫颈癌和乳腺癌的研究。。

Palmitelaidic Acid (9-trans-Hexadecenoic acid) 是反式异构体的棕榈油酸。棕榈油酸是血清和组织中最丰富的脂肪酸之一。

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a drug to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].

HTH-01-015 is a selective NUAK1 inhibitor, but not NUAK2, with IC50 of 100 nM, suppressing NUAK1-mediated MYPT1 phosphorylation.

Dorsomorphin 2HCl 是一种 AMPK 抑制剂，对 AMPK 的 IC50 值为 109 nM。Dorsomorphin 2HCl 具有抑制骨形成蛋白 (BMP) 信号通路的作用，可用于干细胞分化和骨再生的研究。

Gomisin J is a natural product isolated and purified from the fruits of Schizandra chinensis with vasodilatory activity that mediates mainly by calcium-dependent activation of eNOS with subsequent production of endothelial NO, and inhibits LPO in rat liver mitochondria and protects cultured myocardial cells from being injured by calcium paradox.

COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. It significantly reduced intracellular lipid accumulation and downregulated the expression of key adipogenesis-related transcription factors and lipogenic proteins in differentiating adipocytes.

Adenosine 5'-monophosphate disodium salt is an activator of AMPK and can be used as a substrate of AMP-thymidine kinase, AMP deaminase and 5′-nucleotidase.

ASP4132 is a new type of AMPK activator with EC50 value of 18nM. It showed attractive selective growth inhibition against human cancer cells.

PF-06409577 is a potent and selective allosteric activator of AMPK with EC50 value of 7 nM for AMPKα1β1γ1, but >40000 nM for AMPKα1β2γ1.

IM156 is a metformin derivative which has been reported to ameliorate various types of fibrosis and inhibit in vitro and in vivo tumors by inducing AMPK activation more potently than metformin. IM156 treatment impaired the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses. IM156 activated AMPK in a dose-dependent manner, and produced shortening of the circadian period and enhanced degradation of the clock genes PER2 and CRY1.