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2-Pyrazinecarboxylic acid/2-吡嗪羧酸
2-Pyrazinecarboxylic acid/2-吡嗪羧酸
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货号：A401180
同义名：
2-甲酸吡嗪
2-Pyrazinecarboxylic acid 是通过与天冬氨酸脱羧酶 PanD 结合，抑制分枝杆菌辅酶 A 的合成。
2-Pyrazinecarboxylic acid/2-吡嗪羧酸 化学结构
2-Pyrazinecarboxylic acid/2-吡嗪羧酸 3D分子结构
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2-Pyrazinecarboxylic acid/2-吡嗪羧酸 纯度/质量文件 产品仅供科研
货号：A401180
标准纯度：
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产品说明书
全球学术期刊中引用的产品
• Science , 2025, 387(6729): eadp5637. Ambeed. • Nat. Electron. , 2025, 8, 66-74. Ambeed. • Adv. Mater. , 2025, 2416621. Ambeed. • Adv. Mater. , 2025, 2410493. Ambeed. • Adv. Mater. , 2025, 2420319. Ambeed. A106129
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2-Pyrazinecarboxylic acid/2-吡嗪羧酸 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132H-IDH1, IC50: 70 nM
R132C-IDH1, IC50: 0.16 μM
99%+
SW033291
++++
15-PGDH, Ki: 0.1 nM
15-PGDH, IC50: 1.5 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
99%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase I, IC50: 39 nM
Inosine monophosphate dehydrogenase II, IC50: 27 nM
98%
MK-8245
++++
SCD1 (rat), IC50: 3 nM
SCD1 (mouse), IC50: 1 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
2-Pyrazinecarboxylic acid/2-吡嗪羧酸 生物活性
描述
Pyrazinecarboxylic acid is an active metabolite of pyrazinamide. Pyrazinamidean is an anti-tubercular agent. In this model for the evaluation of the effects of uricosuric agents, the urinary excretion of pyrazinecarboxylic acid was decreased by probenecid and indicated an inverse correlation between urinary excretion of urate and pyrazinecarboxylic acid. In the in vitro study, the treatment of the vesicles of rat renal brush-border membrane with pyrazinecarboxylic acid produced an increased urate uptake, which was inhibited by uricosuric agents[2] [3]
2-Pyrazinecarboxylic acid/2-吡嗪羧酸 参考文献
[1] Gopal P, Nartey W, Ragunathan P, Sarathy J, Kaya F, Yee M, Setzer C, Manimekalai MSS, Dartois V, Grüber G, Dick T. Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD. ACS Infect Dis. 2017 Nov 10;3(11):807-819. doi: 10.1021/acsinfecdis.7b00079. Epub 2017 Oct 18. PMID: 28991455; PMCID: PMC5734868.
[2] Taniguchi T, Ashizawa N, Matsumoto K, Iwanaga T. Enhancement of pharmacological effects of uricosuric agents by concomitant treatment with pyrazinamide in rats. Naunyn Schmiedebergs Arch Pharmacol. 2017;390(3):253‐260
[3] Sun X, Li Y, He W, et al. Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nat Commun. 2017;8:15758. Published 2017 Jun 12
2-Pyrazinecarboxylic acid/2-吡嗪羧酸 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
8.06mL
1.61mL
0.81mL
40.29mL
8.06mL
4.03mL
80.58mL
16.12mL
8.06mL
2-Pyrazinecarboxylic acid/2-吡嗪羧酸 技术信息
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