2-Pyrazinecarboxylic acid
产品说明书
 |
同义名 : | 2-甲酸吡嗪 |
| CAS号 : | 98-97-5 | |
| 货号 : | A401180 | |
| 分子式 : | C5H4N2O2 | |
| 纯度 : | 98% | |
| 分子量 : | 124.1 | |
| MDL号 : | MFCD00006130 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 50 mg/mL(402.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Pyrazinecarboxylic acid is an active metabolite of pyrazinamide. Pyrazinamidean is an anti-tubercular agent. In this model for the evaluation of the effects of uricosuric agents, the urinary excretion of pyrazinecarboxylic acid was decreased by probenecid and indicated an inverse correlation between urinary excretion of urate and pyrazinecarboxylic acid. In the in vitro study, the treatment of the vesicles of rat renal brush-border membrane with pyrazinecarboxylic acid produced an increased urate uptake, which was inhibited by uricosuric agents[2]. PZA (pyrazinamide) is converted to pyrazinecarboxylic acid (POA) in plant cells, suppressing the activity of 1-aminocyclopropane-1-carboxylic acid oxidase (ACO), the enzyme catalysing the final step of ethylene formation[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
8.06mL 1.61mL 0.81mL |
40.29mL 8.06mL 4.03mL |
80.58mL 16.12mL 8.06mL |
| 参考文献 |
|---|