Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
肿瘤
/
DNA损伤
细胞周期 肿瘤表观遗传和基因调控
/
MTH1
DNA
/ (S)-Crizotinib

(S)-Crizotinib {[allProObj[0].p_purity_real_show]}

货号：A419254

(S)-Crizotinib 是一种强效、选择性的 MTH1（mutT 同源物）抑制剂，IC50 为 330 nM。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
(S)-Crizotinib 化学结构 CAS号：1374356-45-2
(S)-Crizotinib 化学结构
CAS号：1374356-45-2
(S)-Crizotinib 3D分子结构
CAS号：1374356-45-2
(S)-Crizotinib 化学结构 CAS号：1374356-45-2
(S)-Crizotinib 3D分子结构 CAS号：1374356-45-2
规格 价格 会员价 库存 数量
{[ item.pr_size ]} {[ size_append(item.pr_size_append, item.pr_am, item.pr_size) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

(S)-Crizotinib 纯度/质量文件 产品仅供科研

货号：A419254 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025, 188, (21): 5847-5861.e11. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025, 20, 1502-1513. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 MTH1 ↓ 其他靶点 纯度
TH588 +++

MTH1, IC50: 5 nM

 		99%+
TH287 ++++

MTH1, IC50: 0.8 nM

 		99%
(S)-Crizotinib ++

MTH1, IC50: 72 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Oxolinic acid ✔ 98+%
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

BLM636-1298, IC50: 0.97 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 98%
Favipiravir ✔ 99%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 99%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, Kd: 42.1 nM

Leucyl-tRNA synthetase, IC50: 46.11 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(S)-Crizotinib 生物活性

靶点

  • MTH1

    MTH1, IC50:72 nM
描述 (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.

(S)-Crizotinib 细胞实验

Cell Line
Concentration Treated Time Description References
H1975 cells 0.625-80 µM 24 hours Measure cell viability, IC50 value was 16.54 μM J Exp Clin Cancer Res. 2017 Sep 7;36(1):120.
HT-1080 cells 1 µM 24 hours Inhibits RSL3-induced ferroptosis Cell Death Discov. 2024 Aug 12;10(1):360.
SK-HEP-1 cells 1 µM 10 hours Inhibits RSL3-induced ferroptosis Cell Death Discov. 2024 Aug 12;10(1):360.
A549 cells 0.625-80 µM 24 hours Measure cell viability, IC50 value was 11.25 μM J Exp Clin Cancer Res. 2017 Sep 7;36(1):120.
U2OS cells 5 µM 24 hours Induces formation of DNA single strand breaks due to activation of endogenous base excision repair Nature. 2014 Apr 10;508(7495):222-7.
NCI-H460 cells 0.625-80 µM 24 hours Measure cell viability, IC50 value was 14.29 μM J Exp Clin Cancer Res. 2017 Sep 7;36(1):120.
BGC-823/R >100 µM (IC50) 24 hours To evaluate the effect of (S)-crizotinib on the viability of resistant gastric cancer cells, results showed that resistant cells had significantly reduced sensitivity to (S)-crizotinib. Cell Death Dis. 2018 May 31;9(6):660.
BGC-823 24.81 µM (IC50) 24 hours To evaluate the effect of (S)-crizotinib on the viability of gastric cancer cells, results showed that (S)-crizotinib significantly reduced cell viability and induced apoptosis. Cell Death Dis. 2018 May 31;9(6):660.
SGC-7901 21.33 µM (IC50) 24 hours To evaluate the effect of (S)-crizotinib on the viability of gastric cancer cells, results showed that (S)-crizotinib significantly reduced cell viability and induced apoptosis. Cell Death Dis. 2018 May 31;9(6):660.
L145 CRC spheroids 10 µM 3 days Assessment of cell viability, results showed (S)-crizotinib significantly reduced cell viability Sci Rep. 2019 Jan 28;9(1):819.
P25T and p26T patient-derived organoids 5 µM 3 days Assessment of cell viability, results showed (S)-crizotinib significantly reduced cell viability Sci Rep. 2019 Jan 28;9(1):819.
SW480 cells 2 µM 3 days Induces DNA damage as indicated by an increase in 53BP1 foci and ATM autophosphorylation Nature. 2014 Apr 10;508(7495):222-7.
SW480 colon carcinoma cells 5 µM 3 hours To evaluate the thermal stabilization effect of (S)-Crizotinib on MTH1 protein, results showed that (S)-Crizotinib significantly stabilized MTH1 protein, while DMSO-treated control cells showed a sharp decline in MTH1 protein content. Nat Methods. 2015 Nov;12(11):1055-7.
SW480 cell lysates 100 µM 30 minutes To assess the target profile of (S)-Crizotinib in cell lysates, results revealed not only MTH1 but also several kinases as targets, suggesting that cellular compartmentalization may affect the compound's target profile. Nat Methods. 2015 Nov;12(11):1055-7.
U251MG cells 0.1 nM to 10 µM 30 minutes Competitive binding assays showed that (S)-Crizotinib has lower affinity for MTH1 with a Ki value of 153.90 ± 20.48 nM Int J Mol Sci. 2020 Nov 23;21(22):8860.
786-O cells 1 µM 4 hours Inhibits RSL3-induced lipid-ROS accumulation Cell Death Discov. 2024 Aug 12;10(1):360.

(S)-Crizotinib 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Nude mice (BALB/c nu/nu) Gastric cancer xenograft model Intraperitoneal injection 10 mg/kg (S)-crizotinib, 5 mg/kg MK2206 Once daily for 24 days To evaluate the inhibitory effect of (S)-crizotinib alone or in combination with MK2206 on the growth of gastric cancer xenografts, results showed that the combined treatment significantly inhibited tumor growth. Cell Death Dis. 2018 May 31;9(6):660.
SCID mice SW480 colon carcinoma xenograft model Subcutaneous and oral administration 25 mg/kg (subcutaneous), 50 mg/kg (oral) Once daily for 35 days (subcutaneous), 26 days (oral) Suppresses tumour growth, reduces tumour volume by more than 50% Nature. 2014 Apr 10;508(7495):222-7.
Mice Kidney ischemia-reperfusion injury model Intraperitoneal injection 4 mg/kg and 10 mg/kg Single injection, lasting 24 hours Alleviates renal ischemia-reperfusion injury Cell Death Discov. 2024 Aug 12;10(1):360.
BALB/c nu/nu female mice NCI-H460 xenograft model Intraperitoneal injection 7.5 or 15 mg/kg Once daily for 10 days Evaluate the inhibitory effect of (S)-Crizotinib on tumor growth, results showed significant reductions in tumor volume and weight J Exp Clin Cancer Res. 2017 Sep 7;36(1):120.

(S)-Crizotinib 参考文献

[1]Huber KV, Salah E, et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508(7495):222-7.

(S)-Crizotinib 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.21mL

4.44mL

2.22mL

(S)-Crizotinib 技术信息

CAS号1374356-45-2
分子式C21H22Cl2FN5O
分子量 450.34
SMILES Code NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C
MDL No. MFCD22126092
别名
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 12 mg/mL(26.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: (S)-Crizotinib | 1374356-45-2 | Selective MTH1 Inhibitor | Cell Cycle/DNA Damage | Apoptosis | DNA/RNA Synthesis | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | (S)-Crizotinib 纯度/质量文件 | (S)-Crizotinib 亚型比较 | (S)-Crizotinib 生物活性 | (S)-Crizotinib 参考文献 | (S)-Crizotinib 实验方案 | (S)-Crizotinib 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z