TH5427是一种NUDT5抑制剂，能够阻断孕激素依赖性PAR衍生的核ATP合成，对乳腺癌的研究具有潜力。

(S)-Crizotinib 是一种强效、选择性的 MTH1（mutT 同源物）抑制剂，IC50 为 330 nM。

TH588 是一种高度选择性的 MTH1 (NUDT1) 抑制剂，IC50 为 5 nM。

TH287是一种选择性的MTH1抑制剂，IC50值为0.8 nM。

MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity[1].

BAY-707 is a potent and cellularly active inhibitor devalidate MTH1 as broad-spectrum cancer target.

TH588 HCl is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM) in cells.

SCH 51344 is a potent MTH1 inhibitor with Kd value of 49nM.