(S)-Crizotinib

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Chemical Structure| 1374356-45-2 同义名 : -
CAS号 : 1374356-45-2
货号 : A419254
分子式 : C21H22Cl2FN5O
纯度 : 98%
分子量 : 450.34
MDL号 : MFCD22126092
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(26.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • MTH1

    MTH1, IC50:72 nM
描述 (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.21mL

4.44mL

2.22mL
参考文献

[1]Huber KV, Salah E, et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508(7495):222-7.