Sterile PBS or 0.9% saline for reconstitution/dilution. It is recommended to use the reconstituted/diluted product within one month.
Infliximab/英夫利昔单抗 细胞实验
Cell Line
Concentration
Treated Time
Description
References
LPMNC from IBD patients
10 µg/mL
18 h
To test the effect of Infliximab on the release of inflammatory cytokines in LPMNC from IBD patients, results showed that Infliximab significantly reduced the release of IL-1β, IL-6, TNFα, CCL2, Mip-1α, and IP-10.
Gut. 2018 Oct;67(10):1813-1823.
Infliximab/英夫利昔单抗 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
Chronic hyperammonemia model
Intravenous injection
5 mg/kg
Weekly for 4 weeks
To assess the role of peripheral inflammation in neuroinflammation and TNF-α induction. The anti-TNF-α antibody (infliximab) prevented microglial and astrocyte activation and TNF-α induction in Purkinje neurons by reducing peripheral inflammation.
J Neuroinflammation. 2020 Feb 22;17(1):70.
Mice
C57BL/6J mice
Subcutaneous injection
30.75 µg/g
Single injection, lasted for 2 weeks
To evaluate the causative effect of antibiotic treatment on ADA formation, results showed that mice pretreated with cephalosporins had significantly higher ADA levels compared to those pretreated with macrolides, and germ-free mice produced no detectable ADA.
Gut. 2022 Feb;71(2):287-295
Mice
TNBS-induced colitis model
Intravenous injection
5 mg/kg
Once daily for 5 days
To monitor the effect of anti-tumor necrosis factor α antibody therapy using P-selectin-targeted US imaging, results showed a significant decrease in US signal in treated mice, which correlated well with P-selectin expression levels.
Radiology. 2012 Jan;262(1):172-80
Mice
DSS-induced colitis model
Intraperitoneal injection
10 mg/kg
Single injection, lasting 7 days
Infliximab suppressed DSS-induced PUMA expression and colitis, alleviating colonic damage and IEC apoptosis.
J Clin Invest. 2011 May;121(5):1722-32
Mice
TNFdARE mouse model
Intraperitoneal injection
100 µg/mouse
Twice a week for 15 days
To evaluate the efficacy of Infliximab in TNFdARE mice, the results showed that Infliximab significantly suppressed inflammatory gene expression, but histological improvement was not significant.
J Crohns Colitis. 2022 Jul 14;16(6):978-991
Mice
DSS-induced colitis model
Intraperitoneal injection
5 mg/kg
2 consecutive days
To evaluate the therapeutic effect of Infliximab on colitis
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