Tubastatin A | HDAC6 Inhibitor | AmBeed-信号通路专用抑制剂

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产品名称	HD1 ↓ ↑	HD2 ↓ ↑	HDAC ↓ ↑	HDAC1 ↓ ↑	HDAC10 ↓ ↑	HDAC11 ↓ ↑	HDAC2 ↓ ↑	HDAC3 ↓ ↑	HDAC4 ↓ ↑	HDAC5 ↓ ↑	HDAC6 ↓ ↑	HDAC7 ↓ ↑	HDAC8 ↓ ↑	HDAC9 ↓ ↑	其他靶点	纯度
Givinostat HCl monohydrate	++++ HD1-A, IC50: 16 nM HD1-B, IC50: 7.5 nM	+++ HD2, IC50: 10 nM														99%+
MC1568	++ HD1-B (Maize), IC50: 3.4 μM HD1-A (Maize), IC50: 100 nM															96%
Trichostatin A			++++ HDAC, IC50: ~1.8 nM													99%+
Scriptaid			✔													99%+
Valproic acid sodium			✔												Autophagy	97%
AR-42			+++ HDAC, IC50: 30 nM													99%+
Dacinostat			+++ HDAC, IC50: 32 nM													98+%
CUDC-101			++++ HDAC, IC50: 4.4 nM	++++ HDAC1, IC50: 4.5 nM	+++ HDAC10, IC50: 26.1 nM		+++ HDAC2, IC50: 12.6 nM	++++ HDAC3, IC50: 9.1 nM	+++ HDAC4, IC50: 13.2 nM	+++ HDAC5, IC50: 11.4 nM	++++ HDAC6, IC50: 5.1 nM	+ HDAC7, IC50: 373 nM	++ HDAC8, IC50: 79.8 nM	++ HDAC9, IC50: 67.2 nM	EGFR,HER2	99%+
M344			++ HDAC, IC50: 100 nM													99%+
Splitomicin			+ Sir2p, IC50: 60 μM													99%
Panobinostat			++++ HDAC (MOLT-4 cells), IC50: 5 nM HDAC (Reh cells), IC50: 20 nM													98%
Sodium 4-Phenylbutyrate			✔													98%
Vorinostat			+++ HDAC, IC50: ~10 nM													98%
Curcumin			✔												Nrf2,NF-κB	98%
Belinostat			+++ HDAC, IC50: 27 nM													98%
RG-2833				++ HDAC1, Ki: 32 nM				++ HDAC3, Ki: 5 nM								98%
Valproic acid				+ HDAC1, IC50: 0.4 mM												98%
BG45				+ HDAC1, IC50: 2 μM			+ HDAC2, IC50: 2.2 μM	+ HDAC3, IC50: 289 nM								99%+
Entinostat				+ HDAC1, IC50: 0.51 μM				+ HDAC3, IC50: 1.7 μM								98%
Resminostat				+++ HDAC1, IC50: 42.5 nM				++ HDAC3, IC50: 50.1 nM			++ HDAC6, IC50: 71.8 nM					98+%
Romidepsin				+++ HDAC1, IC50: 36 nM			+++ HDAC2, IC50: 47 nM									99%+
Parthenolide				✔											p53,NF-κB	97% HPLC
Tacedinaline				+ HDAC1, IC50: 0.9 μM			+ HDAC2, IC50: 0.9 μM	+ HDAC3, IC50: 1.2 μM								98%
Mocetinostat				++ HDAC1, IC50: 0.15 μM		+ HDAC11, IC50: 0.59 μM	+ HDAC2, IC50: 0.29 μM	+ HDAC3, IC50: 1.66 μM								98%
WT-161				++++ HDAC1, IC50: 8.35 nM			+++ HDAC2, IC50: 15.4 nM				++++ HDAC6, IC50: 0.4 nM					99%+
Fimepinostat				++++ HDAC1, IC50: 1.7 nM	++++ HDAC10, IC50: 2.8 nM	++++ HDAC11, IC50: 5.4 nM	++++ HDAC2, IC50: 5.0 nM	++++ HDAC3, IC50: 1.8 nM			+++ HDAC6, IC50: 27 nM					99%+
Tucidinostat				++ HDAC1, IC50: 95 nM	++ HDAC10, IC50: 78 nM		++ HDAC2, IC50: 160 nM	++ HDAC3, IC50: 67 nM								99%+
Santacruzamate A							++++ HDAC2, IC50: 119 pM									99%+
(E,E)-RGFP966								++ HDAC3, IC50: 80 nM								99%+
LMK-235									+++ HDAC4, IC50: 11.9 nM	++++ HDAC5, IC50: 4.2 nM						99%+
Tasquinimod									✔							99%+
CAY10603											++++ HDAC6, IC50: 2 pM					98%
Tubastatin A											+++ HDAC6, IC50: 15 nM					98%
Tubacin											++++ HDAC6, IC50: 4 nM					99%+
ACY-738											++++ HDAC6, IC50: 1.7 nM					99%+
Nexturastat A											++++ HDAC6, IC50: 5 nM					99%+
BRD73954											+++ HDAC6, IC50: 36 nM		++ HDAC8, IC50: 120 nM			99%
Tubastatin A HCl											+++ HDAC6, IC50: 15 nM		+ HDAC8, IC50: 854 nM			98%
PCI-34051													+++ HDAC8, IC50: 10 nM			99%+
Ricolinostat				++ HDAC1, IC50: 58 nM			++ HDAC2, IC50: 48 nM	++ HDAC3, IC50: 51 nM			++++ HDAC6, IC50: 4.7 nM		++ HDAC8, IC50: 100 nM			99%+
Droxinostat								+ HDAC3, IC50: 16.9 μM			+ HDAC6, IC50: 2.47 μM		+ HDAC8, IC50: 1.46 μM			99%+
Abexinostat				++++ HDAC1, Ki: 7 nM	+++ HDAC10, IC50: 24 nM		+++ HDAC2, Ki: 19 nM	++++ HDAC3/SMRT, Ki: 8.2 nM			+++ HDAC6, Ki: 17 nM		+ HDAC8, IC50: 280 nM			98%+
Citarinostat				+++ HDAC1, IC50: 35 nM			+++ HDAC2, IC50: 45 nM	+++ HDAC3, IC50: 46 nM			++++ HDAC6, IC50: 2.6 nM		++ HDAC8, IC50: 137 nM			99%+
HPOB				+ HDAC1, IC50: 2.9 μM	+ HDAC10, IC50: 3.0 μM		+ HDAC2, IC50: 4.4 μM	+ HDAC3, IC50: 1.7 μM			++ HDAC6, IC50: 56 nM		+ HDAC8, IC50: 2.8 μM			97%
Quisinostat 2HCl				++++ HDAC1, IC50: 0.11 nM	++++ HDAC10, IC50: 0.46 nM	++++ HDAC11, IC50: 0.37 nM	++++ HDAC2, IC50: 0.33 nM	++++ HDAC3, IC50: 4.86 nM	++++ HDAC4, IC50: 0.64 nM	++++ HDAC5, IC50: 3.69 nM			++++ HDAC8, IC50: 4.26 nM			97%
Domatinostat				+ HDAC1, IC50: 1.20 μM	+ HDAC10, IC50: 21 μM	+ HDAC11, IC50: 9.7 μM	+ HDAC2, IC50: 1.12 μM	+ HDAC3, IC50: 0.57 μM		+ HDAC5, IC50: 11.3 μM				+ HDAC9, IC50: 50 μM		99%+
TMP269									++ HDAC4, IC50: 157 nM	++ HDAC5, IC50: 97 nM		+++ HDAC7, IC50: 43 nM		+++ HDAC9, IC50: 23 nM		99%+
Pracinostat				++ HDAC1, IC50: 49 nM	+++ HDAC10, IC50: 40 nM	++ HDAC11, IC50: 93 nM	++ HDAC2, IC50: 96 nM	+++ HDAC3, IC50: 43 nM	++ HDAC4, IC50: 56 nM	+++ HDAC5, IC50: 47 nM	+ HDAC6, IC50: 1.008 μM	++ HDAC7, IC50: 137 nM	++ HDAC8, IC50: 140 nM	++ HDAC9, IC50: 70 nM		99%+
TMP195									++ HDAC4, Ki: 59 nM	++ HDAC5, Ki: 60 nM		+++ HDAC7, Ki: 26 nM		+++ HDAC9, Ki: 15 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

靶点	HDAC6 HDAC6, IC50:15 nM
描述	HDACs (Histone deacetylases) are a group of enzymes that remove acetyl groups and regulate the histone tail, protein-DNA interaction, chromatin conformation, and even transcription. There are 18 mammalian HDACs, HDAC 1-11 and sirt 1-7^[2]. Tubastatin A, a derivative from tubacin, is a selective HDAC6 inhibitor with IC50 value of 15nM (measured by purified human HDAC protein), over 1000-fold selectivity against HDAC1. Treatment of Tubastatin A with low concentration (2.5uM) results in an α-tubulin hyperacetylation, corresponding to HDAC6 inhibition, rather than histone hyperacetylation, corresponding to class I HDAC inhibition, which shows the selectivity to HDAC6 of tubastatin A. Tubastatin A possesses the function of modulation of several neurodegenerative diseases. In an HCA oxidative stress assay, tubastatin A displayed neuroprotection against HCA-induced neuronal cell death at 5-10 µM in a dose-dependent manner^[1]. Tubastatin A can also increase autophagic flux and reduce diffuse mutant huntingtin in striatal neurons^[3]. Compared with tubacin, tubastatin A possesses a drug-like property, which makes it more considered as a promising anti-cancer drug^[4]. Combination with tubastatin A can enhance the TMZ-induced cytotoxicity in TMZ-resistant glioma cell lines at concentration < 30 μM^[5].
作用机制	Tubastatin has a hydroxamate-based structure, which can chelate the Zn²⁺ ion of HDACs. ^[1]

Cell Line RN46A-B14 cells TKPTS cells RAW264.7 cells CD8+ T cells Naïve CD4+ T cells iBMDMs	Concentration	Treated Time	Description	References
RN46A-B14 cells	2.5 μM	1 h	To test the effect of Tubastatin A on hormone-induced GR translocation, results showed that Tubastatin A significantly inhibited DEX-induced GR translocation.	Biol Psychiatry. 2015 Feb 15;77(4):345-55.
TKPTS cells	100nM	24 h	To study the effect of HDAC6 inhibition on AMWAP expression, results showed that Tubastatin A slightly increased AMWAP expression in TKPTS cells.	Kidney Int. 2016 Feb;89(2):317-26.
RAW264.7 cells	100nM	24 h	To study the effect of HDAC6 inhibition on AMWAP expression, results showed that Tubastatin A did not increase AMWAP expression in RAW264.7 cells.	Kidney Int. 2016 Feb;89(2):317-26.
CD8+ T cells	10 μM	24 h	Screening for compounds that promote IFN-γ expression in CD8+ T cells, Tubastatin A significantly promoted IFN-γ expression with low cellular toxicity.	Immunity. 2019 Sep 17;51(3):491-507.e7.
Naïve CD4+ T cells	10 μM	24 h	Tubastatin A significantly suppressed the differentiation of Naïve CD4+ T cells under Th17-skewing conditions and reduced the expression of IL-17A and RORγt mRNA.	Theranostics. 2020 May 21;10(15):6790-6805.
iBMDMs	10 μM	1 h	Inhibited NLRP3 inflammasome activation, reduced caspase-1 processing and IL-1β release	Science. 2020 Sep 18;369(6510):eaas8995.

Species Mice Mice Mice Mice Mice	Animal Model B16-OVA melanoma model MCAO model Acute lung allograft rejection model LPS-induced endotoxic shock model Photothrombotic ischemia model	Administration	Dosage	Frequency	Description	References
Mice	B16-OVA melanoma model	Intratumoral injection	60 μg/mouse	Daily until the end of the experiment	To evaluate the inhibitory effect of Tubastatin A and acetate combination therapy on tumor growth, the results showed that the combination therapy significantly inhibited tumor growth.	Immunity. 2019 Sep 17;51(3):491-507.e7.
Mice	MCAO model	Intraperitoneal injection	0.5 mg/kg	Every two days	By inhibiting HDAC6, the study investigated its impact on functional recovery after stroke. The results showed that HDAC6 inhibition significantly reduced the dendritic length and branch number of newly generated neurons.	J Biomed Sci. 2019 Apr 18;26(1):27
Mice	Acute lung allograft rejection model	Intraperitoneal injection	30 mg/kg	Once daily until lung allograft loss	Tubastatin A significantly attenuated the pathological lesions of acute lung allograft rejection, prolonged the survival of lung allografts, and attenuated acute rejection by suppressing Th17 cell accumulation.	Theranostics. 2020 May 21;10(15):6790-6805.
Mice	LPS-induced endotoxic shock model	Intraperitoneal injection	70 mg/kg	Single dose, lasting 12 hours	Tubastatin A significantly reduced LPS-induced IL-1β and IL-18 secretion and alleviated acute lung injury	Science. 2020 Sep 18;369(6510):eaas8995.
Mice	Photothrombotic ischemia model	Intraperitoneal injection	10 mg/kg	Once daily for 3 days	To study the protective effect of HDAC6 inhibition on ischemic brain injury	Cell Death Dis. 2022 May 18;13(5):466

Dose	Mice^[8] (i.p.): 10 mg/kg - 100 mg/kg
Administration	i.p.

CAS号	1252003-15-8
分子式	C₂₀H₂₁N₃O₂
分子量	335.4
SMILES Code	O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1
MDL No.	MFCD18071463

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别名
运输	蓝冰
InChI Key	GOVYBPLHWIEHEJ-UHFFFAOYSA-N
Pubchem ID	49850262

human HeLa cells	Function assay	6 h	Inhibition of HDAC6 in human HeLa cells assessed as reduction in K40 hyperacetylation of alpha-tubulin incubated for 6 hrs by immunofluorescence assay, IC50=2.5 μM.	25454270
human Jurkat cells	Cytotoxic assay	72 h	Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTS assay, IC50=3.38 μM.	24304348
human KB cells	Cytotoxic assay	72 h	Cytotoxicity against human KB cells after 72 hrs by MTS assay, IC50=14.81 μM.	25899338
human LNCAP cells	Cytotoxic assay	72 h	Cytotoxicity against androgen-dependent human LNCAP cells assessed as growth inhibition after 72 hrs by MTS assay, IC50=10.88 μM.	24304348
mouse B16 cells	Growth inhibition assay		Growth inhibition of mouse B16 cells incubated for 48 hrs by MTT assay, GI50=40.5 μM.	23009203
Sf9 cells	Function assay		Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate, IC50=15 nM.	23009203

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