组蛋白去乙酰化酶 | HDAC

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组蛋白去乙酰化酶相关产品
HDAC 亚型比较

全部(405) Modulator(1) Inhibitor(63) Activator(4)

货号			产品名	纯度
A970825	现货	促	HDAC3-IN-T247 HDAC3-IN-T247是一种有效的选择性 HDAC3 抑制剂，IC50 为 0.24 μM，能够诱导 HCT116 细胞选择性增加 NF-κB 的乙酰化，具有抗癌和抗病毒作用，并可抑制癌细胞的生长和激活潜伏在 HIV 感染细胞中的 HIV 基因表达。	95% HPLC
A161831	现货	促	Tubastatin A Tubastatin A 是一种有效且选择性的 HDAC6 抑制剂，IC50 为 15 nM，对 HDAC8 的选择性高出 57 倍，对其他同工酶的选择性高出 1000 倍以上。Tubastatin A 还抑制 HDAC10 和 MBLAC2。	98%
A301260	现货	促	Pimelic Diphenylamide 106 Pimelic diphenylamide 106 is an inhibitor of class I HDAC with IC50 for HDAC1, HDAC2, and HDAC3 of 150 nM, 760nM, and 370 nM, respectively.	99%+
A113603	现货	促	Givinostat HCl monohydrate ITF2357 HCl H2O is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively.	99%+
A567414	现货	促	SKLB-23bb HDAC6-IN-1 is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively	99%+
A698765	现货	促	MPI_5a MPI-5a is an effective and selective inhibitor of HDAC6 with IC50 value of 36nM.	97%
A251359	现货	促	HDAC-IN-3 HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor.	99%
A293543	现货	促	Nexturastat A Nexturastat A is a selective inhibitor of HDAC6 with IC50 of 5 nM.	99%+
A822432	现货	促	BRD3308 BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs.	99%+
A719547	现货	促	BRD 4354/BRD 4354游离态 BRD 4354 is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively.	98%
A579458	现货	促	Pivanex/新戊酰基氧基甲基丁酸酯 Pivanex (AN-9) 是丁酸的衍生物，是一种口服有效的HDAC抑制剂，能够下调bcr-abl蛋白并增强细胞凋亡，具有抗转移和抗血管生成活性。	95%
A503709	现货	促	BML-210 BML-210 is the HDAC inhibitor, and its mechanism of action has not been characterized.	98%
A201295	现货	促	M344/4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺 M344 is HDAC inhibitor with IC50 of 100 nM and can induce cell differentiation.	99%+
A242924	现货	促	Carbamazepine/卡马西平 Carbamazepine is a blocker of sodium channel with IC50 of 131 μM in rat brain synaptosomes. It is an anticonvulsant drug.	98%
A1193427	现货	促	CG347B CG347B is a biochemical.	99%+
A1483491	现货	促	Crebinostat Crebinostat是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂，能诱导组蛋白 H3 和 H4 乙酰化，增强 CREB 靶基因 Egr1 的表达，并调节染色质介导的神经可塑性，具有增强记忆和神经元连接的潜力。	98%
A1505054	现货	促	9-Hydroxyoctadecanoic acid/9-羟基十八酸 9-Hydroxyoctadecanoic acid是一种 HDAC1 抑制剂，在 5 μM 浓度下可抑制 66.4% 的 HDAC1 活性，显示出抗癌活性，适用于癌症治疗的研究。	98%+
A675299	现货	促	Marein/马里甙 Marein是一种通过激活 CaMKK/AMPK/GLUT1 信号通路促进葡萄糖摄取的神经保护剂，同时能够通过 IRS/Akt/GSK-3β 通路增加糖原合成，改善胰岛素抵抗，并通过 AMPK 信号通路减少线粒体功能损伤，具有抗氧化、抗糖尿病等多重生物活性。	99%+
A1177031	现货	促	SW-100 SW-100是一种选择性组蛋白脱乙酰基酶 6 (HDAC6) 抑制剂，IC₅₀ 为 2.3 nM，其选择性相对于其他 HDAC 酶高达 1000 倍，并具有良好的跨越血脑屏障的能力。	99%+
A1209426	现货	促	BRD6688 BRD6688是一种选择性的 HDAC2 抑制剂，可增加原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白乙酰化，能够穿透血脑屏障，在 CK-p25 小鼠模型中缓解与 p25 诱导的神经退行性病变相关的记忆缺陷。	98%+

产品名	HD1 ↓ ↑	HD2 ↓ ↑	HDAC ↓ ↑	HDAC1 ↓ ↑	HDAC10 ↓ ↑	HDAC11 ↓ ↑	HDAC2 ↓ ↑	HDAC3 ↓ ↑	HDAC4 ↓ ↑	HDAC5 ↓ ↑	HDAC6 ↓ ↑	HDAC7 ↓ ↑	HDAC8 ↓ ↑	HDAC9 ↓ ↑	其他靶点	纯度
Givinostat HCl monohydrate	++++ HD1-A, IC50: 16 nM HD1-B, IC50: 7.5 nM	+++ HD2, IC50: 10 nM														99%+
MC1568	++ HD1-B (Maize), IC50: 3.4 μM HD1-A (Maize), IC50: 100 nM															96%
Trichostatin A			++++ HDAC, IC50: ~1.8 nM													99%+
Scriptaid			✔													99%+
Valproic acid sodium			✔												Autophagy	97%
AR-42			+++ HDAC, IC50: 30 nM													99%+
Dacinostat			+++ HDAC, IC50: 32 nM													98+%
CUDC-101			++++ HDAC, IC50: 4.4 nM	++++ HDAC1, IC50: 4.5 nM	+++ HDAC10, IC50: 26.1 nM		+++ HDAC2, IC50: 12.6 nM	++++ HDAC3, IC50: 9.1 nM	+++ HDAC4, IC50: 13.2 nM	+++ HDAC5, IC50: 11.4 nM	++++ HDAC6, IC50: 5.1 nM	+ HDAC7, IC50: 373 nM	++ HDAC8, IC50: 79.8 nM	++ HDAC9, IC50: 67.2 nM	EGFR,HER2	99%+
M344			++ HDAC, IC50: 100 nM													99%+
Splitomicin			+ Sir2p, IC50: 60 μM													95%
Panobinostat			++++ HDAC (MOLT-4 cells), IC50: 5 nM HDAC (Reh cells), IC50: 20 nM													98%
Sodium 4-Phenylbutyrate			✔													98%
Vorinostat			+++ HDAC, IC50: ~10 nM													98%
Curcumin			✔												Nrf2,NF-κB	98%
Belinostat			+++ HDAC, IC50: 27 nM													98%
RG-2833				++ HDAC1, Ki: 32 nM				++ HDAC3, Ki: 5 nM								98%
Valproic acid				+ HDAC1, IC50: 0.4 mM												98%
BG45				+ HDAC1, IC50: 2 μM			+ HDAC2, IC50: 2.2 μM	+ HDAC3, IC50: 289 nM								99%+
Entinostat				+ HDAC1, IC50: 0.51 μM				+ HDAC3, IC50: 1.7 μM								98%
Resminostat				+++ HDAC1, IC50: 42.5 nM				++ HDAC3, IC50: 50.1 nM			++ HDAC6, IC50: 71.8 nM					98+%
Romidepsin				+++ HDAC1, IC50: 36 nM			+++ HDAC2, IC50: 47 nM									99%+
Parthenolide				✔											NF-κB,p53	97% HPLC
Tacedinaline				+ HDAC1, IC50: 0.9 μM			+ HDAC2, IC50: 0.9 μM	+ HDAC3, IC50: 1.2 μM								98%
Mocetinostat				++ HDAC1, IC50: 0.15 μM		+ HDAC11, IC50: 0.59 μM	+ HDAC2, IC50: 0.29 μM	+ HDAC3, IC50: 1.66 μM								98%
WT-161				++++ HDAC1, IC50: 8.35 nM			+++ HDAC2, IC50: 15.4 nM				++++ HDAC6, IC50: 0.4 nM					99%+
Fimepinostat				++++ HDAC1, IC50: 1.7 nM	++++ HDAC10, IC50: 2.8 nM	++++ HDAC11, IC50: 5.4 nM	++++ HDAC2, IC50: 5.0 nM	++++ HDAC3, IC50: 1.8 nM			+++ HDAC6, IC50: 27 nM					99%+
Tucidinostat				++ HDAC1, IC50: 95 nM	++ HDAC10, IC50: 78 nM		++ HDAC2, IC50: 160 nM	++ HDAC3, IC50: 67 nM								99%+
Santacruzamate A							++++ HDAC2, IC50: 119 pM									99%+
(E,E)-RGFP966								++ HDAC3, IC50: 80 nM								99%+
LMK-235									+++ HDAC4, IC50: 11.9 nM	++++ HDAC5, IC50: 4.2 nM						99%+
Tasquinimod									✔							99%+
CAY10603											++++ HDAC6, IC50: 2 pM					98%
Tubastatin A											+++ HDAC6, IC50: 15 nM					98%
Tubacin											++++ HDAC6, IC50: 4 nM					99%+
ACY-738											++++ HDAC6, IC50: 1.7 nM					99%+
Nexturastat A											++++ HDAC6, IC50: 5 nM					99%+
BRD73954											+++ HDAC6, IC50: 36 nM		++ HDAC8, IC50: 120 nM			98%
Tubastatin A HCl											+++ HDAC6, IC50: 15 nM		+ HDAC8, IC50: 854 nM			98%
PCI-34051													+++ HDAC8, IC50: 10 nM			99%+
Ricolinostat				++ HDAC1, IC50: 58 nM			++ HDAC2, IC50: 48 nM	++ HDAC3, IC50: 51 nM			++++ HDAC6, IC50: 4.7 nM		++ HDAC8, IC50: 100 nM			99%+
Droxinostat								+ HDAC3, IC50: 16.9 μM			+ HDAC6, IC50: 2.47 μM		+ HDAC8, IC50: 1.46 μM			99%+
Abexinostat				++++ HDAC1, Ki: 7 nM	+++ HDAC10, IC50: 24 nM		+++ HDAC2, Ki: 19 nM	++++ HDAC3/SMRT, Ki: 8.2 nM			+++ HDAC6, Ki: 17 nM		+ HDAC8, IC50: 280 nM			98%+
Citarinostat				+++ HDAC1, IC50: 35 nM			+++ HDAC2, IC50: 45 nM	+++ HDAC3, IC50: 46 nM			++++ HDAC6, IC50: 2.6 nM		++ HDAC8, IC50: 137 nM			99%+
HPOB				+ HDAC1, IC50: 2.9 μM	+ HDAC10, IC50: 3.0 μM		+ HDAC2, IC50: 4.4 μM	+ HDAC3, IC50: 1.7 μM			++ HDAC6, IC50: 56 nM		+ HDAC8, IC50: 2.8 μM			97%
Quisinostat 2HCl				++++ HDAC1, IC50: 0.11 nM	++++ HDAC10, IC50: 0.46 nM	++++ HDAC11, IC50: 0.37 nM	++++ HDAC2, IC50: 0.33 nM	++++ HDAC3, IC50: 4.86 nM	++++ HDAC4, IC50: 0.64 nM	++++ HDAC5, IC50: 3.69 nM			++++ HDAC8, IC50: 4.26 nM			99+%
Domatinostat				+ HDAC1, IC50: 1.20 μM	+ HDAC10, IC50: 21 μM	+ HDAC11, IC50: 9.7 μM	+ HDAC2, IC50: 1.12 μM	+ HDAC3, IC50: 0.57 μM		+ HDAC5, IC50: 11.3 μM				+ HDAC9, IC50: 50 μM		99%+
TMP269									++ HDAC4, IC50: 157 nM	++ HDAC5, IC50: 97 nM		+++ HDAC7, IC50: 43 nM		+++ HDAC9, IC50: 23 nM		99%+
Pracinostat				++ HDAC1, IC50: 49 nM	+++ HDAC10, IC50: 40 nM	++ HDAC11, IC50: 93 nM	++ HDAC2, IC50: 96 nM	+++ HDAC3, IC50: 43 nM	++ HDAC4, IC50: 56 nM	+++ HDAC5, IC50: 47 nM	+ HDAC6, IC50: 1.008 μM	++ HDAC7, IC50: 137 nM	++ HDAC8, IC50: 140 nM	++ HDAC9, IC50: 70 nM		99%+
TMP195									++ HDAC4, Ki: 59 nM	++ HDAC5, Ki: 60 nM		+++ HDAC7, Ki: 26 nM		+++ HDAC9, Ki: 15 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

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