Scriptaid | Scriptide | Autophagy Inducer | AmBeed-信号通路专用抑制剂

Scriptaid {[allProObj[0].p_purity_real_show]}

货号：A120568 同义名： Scriptide; GCK1026

Scriptaid是一种 HDAC 抑制剂，对乙酰化 H4 有更强的抑制作用。

Scriptaid 化学结构
CAS号：287383-59-9

Scriptaid 3D分子结构
CAS号：287383-59-9

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组蛋白去乙酰化酶亚型比较

产品名称	HD1 ↓ ↑	HD2 ↓ ↑	HDAC ↓ ↑	HDAC1 ↓ ↑	HDAC10 ↓ ↑	HDAC11 ↓ ↑	HDAC2 ↓ ↑	HDAC3 ↓ ↑	HDAC4 ↓ ↑	HDAC5 ↓ ↑	HDAC6 ↓ ↑	HDAC7 ↓ ↑	HDAC8 ↓ ↑	HDAC9 ↓ ↑	其他靶点	纯度
Givinostat HCl monohydrate	++++ HD1-A, IC50: 16 nM HD1-B, IC50: 7.5 nM	+++ HD2, IC50: 10 nM														99%+
MC1568	++ HD1-A (Maize), IC50: 100 nM HD1-B (Maize), IC50: 3.4 μM															96%
Trichostatin A			++++ HDAC, IC50: ~1.8 nM													99%+
Scriptaid			✔													99%+
Valproic acid sodium			✔												Autophagy	97%
AR-42			+++ HDAC, IC50: 30 nM													99%+
Dacinostat			+++ HDAC, IC50: 32 nM													98+%
CUDC-101			++++ HDAC, IC50: 4.4 nM	++++ HDAC1, IC50: 4.5 nM	+++ HDAC10, IC50: 26.1 nM		+++ HDAC2, IC50: 12.6 nM	++++ HDAC3, IC50: 9.1 nM	+++ HDAC4, IC50: 13.2 nM	+++ HDAC5, IC50: 11.4 nM	++++ HDAC6, IC50: 5.1 nM	+ HDAC7, IC50: 373 nM	++ HDAC8, IC50: 79.8 nM	++ HDAC9, IC50: 67.2 nM	HER2,EGFR	99%+
M344			++ HDAC, IC50: 100 nM													99%+
Splitomicin			+ Sir2p, IC50: 60 μM													99%
Panobinostat			++++ HDAC (Reh cells), IC50: 20 nM HDAC (MOLT-4 cells), IC50: 5 nM													98%
Sodium 4-Phenylbutyrate			✔													98%
Vorinostat			+++ HDAC, IC50: ~10 nM													98%
Curcumin			✔												Nrf2,NF-κB	98%
Belinostat			+++ HDAC, IC50: 27 nM													98%
RG-2833				++ HDAC1, Ki: 32 nM				++ HDAC3, Ki: 5 nM								98%
Valproic acid				+ HDAC1, IC50: 0.4 mM												98%
BG45				+ HDAC1, IC50: 2 μM			+ HDAC2, IC50: 2.2 μM	+ HDAC3, IC50: 289 nM								99%+
Entinostat				+ HDAC1, IC50: 0.51 μM				+ HDAC3, IC50: 1.7 μM								98%
Resminostat				+++ HDAC1, IC50: 42.5 nM				++ HDAC3, IC50: 50.1 nM			++ HDAC6, IC50: 71.8 nM					98+%
Romidepsin				+++ HDAC1, IC50: 36 nM			+++ HDAC2, IC50: 47 nM									99%+
Parthenolide				✔											p53,NF-κB	97% HPLC
Tacedinaline				+ HDAC1, IC50: 0.9 μM			+ HDAC2, IC50: 0.9 μM	+ HDAC3, IC50: 1.2 μM								98%
Mocetinostat				++ HDAC1, IC50: 0.15 μM		+ HDAC11, IC50: 0.59 μM	+ HDAC2, IC50: 0.29 μM	+ HDAC3, IC50: 1.66 μM								98%
WT-161				++++ HDAC1, IC50: 8.35 nM			+++ HDAC2, IC50: 15.4 nM				++++ HDAC6, IC50: 0.4 nM					99%+
Fimepinostat				++++ HDAC1, IC50: 1.7 nM	++++ HDAC10, IC50: 2.8 nM	++++ HDAC11, IC50: 5.4 nM	++++ HDAC2, IC50: 5.0 nM	++++ HDAC3, IC50: 1.8 nM			+++ HDAC6, IC50: 27 nM					99%+
Tucidinostat				++ HDAC1, IC50: 95 nM	++ HDAC10, IC50: 78 nM		++ HDAC2, IC50: 160 nM	++ HDAC3, IC50: 67 nM								99%+
Santacruzamate A							++++ HDAC2, IC50: 119 pM									99%+
(E,E)-RGFP966								++ HDAC3, IC50: 80 nM								99%+
LMK-235									+++ HDAC4, IC50: 11.9 nM	++++ HDAC5, IC50: 4.2 nM						99%+
Tasquinimod									✔							99%+
CAY10603											++++ HDAC6, IC50: 2 pM					98%
Tubastatin A											+++ HDAC6, IC50: 15 nM					98%
Tubacin											++++ HDAC6, IC50: 4 nM					99%+
ACY-738											++++ HDAC6, IC50: 1.7 nM					99%+
Nexturastat A											++++ HDAC6, IC50: 5 nM					99%+
BRD73954											+++ HDAC6, IC50: 36 nM		++ HDAC8, IC50: 120 nM			99%
Tubastatin A HCl											+++ HDAC6, IC50: 15 nM		+ HDAC8, IC50: 854 nM			98%
PCI-34051													+++ HDAC8, IC50: 10 nM			99%+
Ricolinostat				++ HDAC1, IC50: 58 nM			++ HDAC2, IC50: 48 nM	++ HDAC3, IC50: 51 nM			++++ HDAC6, IC50: 4.7 nM		++ HDAC8, IC50: 100 nM			99%+
Droxinostat								+ HDAC3, IC50: 16.9 μM			+ HDAC6, IC50: 2.47 μM		+ HDAC8, IC50: 1.46 μM			99%+
Abexinostat				++++ HDAC1, Ki: 7 nM	+++ HDAC10, IC50: 24 nM		+++ HDAC2, Ki: 19 nM	++++ HDAC3/SMRT, Ki: 8.2 nM			+++ HDAC6, Ki: 17 nM		+ HDAC8, IC50: 280 nM			98%+
Citarinostat				+++ HDAC1, IC50: 35 nM			+++ HDAC2, IC50: 45 nM	+++ HDAC3, IC50: 46 nM			++++ HDAC6, IC50: 2.6 nM		++ HDAC8, IC50: 137 nM			99%+
HPOB				+ HDAC1, IC50: 2.9 μM	+ HDAC10, IC50: 3.0 μM		+ HDAC2, IC50: 4.4 μM	+ HDAC3, IC50: 1.7 μM			++ HDAC6, IC50: 56 nM		+ HDAC8, IC50: 2.8 μM			97%
Quisinostat 2HCl				++++ HDAC1, IC50: 0.11 nM	++++ HDAC10, IC50: 0.46 nM	++++ HDAC11, IC50: 0.37 nM	++++ HDAC2, IC50: 0.33 nM	++++ HDAC3, IC50: 4.86 nM	++++ HDAC4, IC50: 0.64 nM	++++ HDAC5, IC50: 3.69 nM			++++ HDAC8, IC50: 4.26 nM			97%
Domatinostat				+ HDAC1, IC50: 1.20 μM	+ HDAC10, IC50: 21 μM	+ HDAC11, IC50: 9.7 μM	+ HDAC2, IC50: 1.12 μM	+ HDAC3, IC50: 0.57 μM		+ HDAC5, IC50: 11.3 μM				+ HDAC9, IC50: 50 μM		99%+
TMP269									++ HDAC4, IC50: 157 nM	++ HDAC5, IC50: 97 nM		+++ HDAC7, IC50: 43 nM		+++ HDAC9, IC50: 23 nM		99%+
Pracinostat				++ HDAC1, IC50: 49 nM	+++ HDAC10, IC50: 40 nM	++ HDAC11, IC50: 93 nM	++ HDAC2, IC50: 96 nM	+++ HDAC3, IC50: 43 nM	++ HDAC4, IC50: 56 nM	+++ HDAC5, IC50: 47 nM	+ HDAC6, IC50: 1.008 μM	++ HDAC7, IC50: 137 nM	++ HDAC8, IC50: 140 nM	++ HDAC9, IC50: 70 nM		99%+
TMP195									++ HDAC4, Ki: 59 nM	++ HDAC5, Ki: 60 nM		+++ HDAC7, Ki: 26 nM		+++ HDAC9, Ki: 15 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Scriptaid 生物活性

靶点

HDAC

描述

Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research. Scriptaid (1 µg/mL) treatment inhibits cell growth in breast cancer cell lines, results in increased accumulation of both acetyl H3 and acetyl H4 proteins in MDA-MB-231, MDA-MB-435, and Hs578t cells. Scriptaid also inhibits cell growth of MDA-MB-231, MDA-MB-435, and Hs578t cell lines, with IC50s of 0.5-1.0 µg/mL. Scriptaid (0.1-1.0 µg/mL) induces ER and PR mRNA expression in a dose dependent manner; when it is combined with AZA(5-aza-2'-deoxycytidine), they enhance ER expression and induce a functional ER protein (estrogen receptor alpha)^[3]. Scriptaid and SAHA (suberoylanilide hydroxamic acid) preferentially inhibit the Class I histone deacetylases, hdac1, 2, and 3. Scriptaid is a potent anti-T. gondii compound with low cytotoxicity, and the IC50 is 39 nM. Scriptaid has atypical effects in T. gondiiinfected HS68 cells^[4]. Scriptaid inhibited the growth of HeLa cells with IC50 of 2μM at 48h in a dose-dependent manner^[5]. Treatment with 500nM scriptaid caused a significant increase in the acetylation of H3K9, H3K14, and H4K5. cEFs treated with 500nM. Scriptaid showed significantly decreased Gcn5, Hat1, Hdac6, and Bcl2 and increased Oct4 and Sox2 expression levels. Scriptaid affected the reprogramming of canine donor and cloned embryos, as well as early embryo development in canine-porcine iSCNT, by regulating reprogramming and apoptotic genes^[6].

Scriptaid 细胞实验

Cell Line Huh7 cells GM979 cells HepG2 cells Hep3B cells Human BFUe cells Porcine SCNT embryos Porcine fetal fibroblasts (PFF) Human pulmonary artery endothelial cells (HPAECs) Oligodendrocytes UM-HACC-2A cells T98G LN229 A375 cells Rat aortic SMC Microglia HEK293 tau-BiFC cells CRL1790 cells HCT116 cells HT29 cells SW480 cells U87 cells Primary microglia Human breast CAFs (hCAFs) Murine melanoma CAFs (mCAFs)	Concentration	Treated Time	Description	References
Huh7 cells	10 µM	24 hours	Enhance fenretinide-induced apoptosis	Hepatology. 2011 Mar;53(3):865-74.
GM979 cells	2 µM	4 days	Scriptaid induced γ gene promoter activity by 2.6-fold	Blood. 2004 Jan 15;103(2):701-9.
HepG2 cells	10 µM	24 hours	Sensitize HepG2 cells to fenretinide-induced apoptosis	Hepatology. 2011 Mar;53(3):865-74.
Hep3B cells	10 µM	24 hours	Enhance fenretinide-induced apoptosis	Hepatology. 2011 Mar;53(3):865-74.
Human BFUe cells	5 µM	14 days	Scriptaid increased γ/γ + β mRNA ratio by 3.27-fold in BFUe cultures	Blood. 2004 Jan 15;103(2):701-9.
Porcine SCNT embryos	500 nM	15 hours	Evaluate the effect of combined Scriptaid and DRB treatment on transcriptional activity in SCNT embryos, results showed combined treatment significantly inhibited transcriptional activity.	Int J Mol Sci. 2022 Nov 16;23(22):14142.
Porcine fetal fibroblasts (PFF)	500 nM	15 hours	Evaluate the effect of Scriptaid on transcriptional activity, results showed Scriptaid alone did not affect transcriptional activity.	Int J Mol Sci. 2022 Nov 16;23(22):14142.
Human pulmonary artery endothelial cells (HPAECs)	8 µM	24 hours	Induced expression of extracellular superoxide dismutase (EC-SOD) up to 10-fold, whereas expression of the prooxidant gene NADPH oxidase 4 was decreased by more than 95%. We also found that this differential regulation of anti- and prooxidant gene expression resulted in significant attenuation in the cellular levels of reactive oxygen species.	Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. Am J Respir Cell Mol Biol.
Oligodendrocytes	1 µM	24 hours	Scriptaid provides protection to oligodendrocytes treated with microglial conditioned medium	Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2853-8.
UM-HACC-2A cells	10 µM	24 hours	Scriptaid effectively inhibited Snail expression, induced hyperacetylation of histone H3K9, reduced cell migration, and effectively disrupted tumorspheres.	Int J Mol Sci. 2024 Jan 29;25(3):1646.
T98G	5-20 µM	24 hours	Scriptaid reduced glioma cell viability by increasing JNK activation and induced apoptosis.	J Cell Mol Med. 2010 Aug;14(8):2151-61.
LN229	5-20 µM	24 hours	Scriptaid reduced glioma cell viability by increasing JNK activation and induced apoptosis.	J Cell Mol Med. 2010 Aug;14(8):2151-61.
A375 cells	1 µM	3 hours	Evaluate G4 stabilization and DNA damage response of Scriptaid in melanoma cells, results showed Scriptaid significantly stabilized G4s and induced DNA damage	Open Biol. 2025 Feb;15(2):240183.
Rat aortic SMC	6 µM	30 minutes	Inhibited mitogen-induced SMC proliferation by preventing Rb protein phosphorylation and cell cycle G1→S phase progression	Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):851-60.
Microglia	1 µM	48 hours	Scriptaid indirectly protects oligodendrocytes by modulating microglial polarization and reducing inflammatory responses	Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2853-8.
HEK293 tau-BiFC cells	3 µM	48 hours	To evaluate the effect of Scriptaid on tau aggregation, results showed that Scriptaid significantly increased tau-BiFC fluorescence intensity, indicating increased tau aggregation.	Int J Mol Sci. 2019 Sep 1;20(17):4283.
CRL1790 cells	128.8 µM (IC50)	48 hours	Evaluate cytotoxic activity of Scriptaid in non-tumoral colon epithelial cells, results showed Scriptaid induced cytotoxicity	Open Biol. 2025 Feb;15(2):240183.
HCT116 cells	42.8 µM (IC50)	48 hours	Evaluate cytotoxic activity of Scriptaid in colorectal cancer cells, results showed Scriptaid induced cytotoxicity	Open Biol. 2025 Feb;15(2):240183.
HT29 cells	8.9 µM (IC50)	48 hours	Evaluate cytotoxic activity of Scriptaid in colorectal cancer cells, results showed Scriptaid induced cytotoxicity	Open Biol. 2025 Feb;15(2):240183.
SW480 cells	9.6 µM (IC50)	48 hours	Evaluate cytotoxic activity of Scriptaid in colorectal cancer cells, results showed Scriptaid induced cytotoxicity	Open Biol. 2025 Feb;15(2):240183.
U87 cells	3.2 µM	48 hours or 72 hours	To verify whether Scriptaid could enhance the inhibitory effect of temozolomide on U87 cell proliferation. Results showed that Scriptaid combined with temozolomide significantly inhibited U87 cell proliferation.	Front Immunol. 2025 Jan 21;15:1523034.
Primary microglia	1 µM	6 hours	Scriptaid modulated microglia polarization, reduced pro-inflammatory cytokine secretion, and protected oligodendrocytes from hemoglobin-induced injury.	J Cereb Blood Flow Metab. 2021 May;41(5):958-974.
Human breast CAFs (hCAFs)	10 µM	7 days	To study the reversal effect of Scriptaid on CAF marker expression. Results showed Scriptaid reduced the expression of SMA, fibronectin, col1, and palladin.	Br J Cancer. 2018 May;118(10):1359-1368.
Murine melanoma CAFs (mCAFs)	10 µM	7 days	To study the reversal effect of Scriptaid on CAF marker expression. Results showed Scriptaid reduced the expression of SMA, fibronectin, col1, and palladin.	Br J Cancer. 2018 May;118(10):1359-1368.

Cell Line

Concentration

Treated Time

Description

References

Huh7 cells

10 µM

24 hours

Enhance fenretinide-induced apoptosis

Hepatology. 2011 Mar;53(3):865-74.

GM979 cells

2 µM

4 days

Scriptaid induced γ gene promoter activity by 2.6-fold

Blood. 2004 Jan 15;103(2):701-9.

HepG2 cells

10 µM

24 hours

Sensitize HepG2 cells to fenretinide-induced apoptosis

Hepatology. 2011 Mar;53(3):865-74.

Hep3B cells

10 µM

24 hours

Enhance fenretinide-induced apoptosis

Hepatology. 2011 Mar;53(3):865-74.

Human BFUe cells

5 µM

14 days

Scriptaid increased γ/γ + β mRNA ratio by 3.27-fold in BFUe cultures

Blood. 2004 Jan 15;103(2):701-9.

Porcine SCNT embryos

500 nM

15 hours

Evaluate the effect of combined Scriptaid and DRB treatment on transcriptional activity in SCNT embryos, results showed combined treatment significantly inhibited transcriptional activity.

Int J Mol Sci. 2022 Nov 16;23(22):14142.

Porcine fetal fibroblasts (PFF)

500 nM

15 hours

Evaluate the effect of Scriptaid on transcriptional activity, results showed Scriptaid alone did not affect transcriptional activity.

Int J Mol Sci. 2022 Nov 16;23(22):14142.

Human pulmonary artery endothelial cells (HPAECs)

8 µM

24 hours

Induced expression of extracellular superoxide dismutase (EC-SOD) up to 10-fold, whereas expression of the prooxidant gene NADPH oxidase 4 was decreased by more than 95%. We also found that this differential regulation of anti- and prooxidant gene expression resulted in significant attenuation in the cellular levels of reactive oxygen species.

Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. Am J Respir Cell Mol Biol.

Oligodendrocytes

1 µM

24 hours

Scriptaid provides protection to oligodendrocytes treated with microglial conditioned medium

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2853-8.

UM-HACC-2A cells

10 µM

24 hours

Scriptaid effectively inhibited Snail expression, induced hyperacetylation of histone H3K9, reduced cell migration, and effectively disrupted tumorspheres.

Int J Mol Sci. 2024 Jan 29;25(3):1646.

T98G

5-20 µM

24 hours

Scriptaid reduced glioma cell viability by increasing JNK activation and induced apoptosis.

J Cell Mol Med. 2010 Aug;14(8):2151-61.

LN229

5-20 µM

24 hours

Scriptaid reduced glioma cell viability by increasing JNK activation and induced apoptosis.

J Cell Mol Med. 2010 Aug;14(8):2151-61.

A375 cells

1 µM

3 hours

Evaluate G4 stabilization and DNA damage response of Scriptaid in melanoma cells, results showed Scriptaid significantly stabilized G4s and induced DNA damage

Open Biol. 2025 Feb;15(2):240183.

Rat aortic SMC

6 µM

30 minutes

Inhibited mitogen-induced SMC proliferation by preventing Rb protein phosphorylation and cell cycle G1→S phase progression

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):851-60.

Microglia

1 µM

48 hours

Scriptaid indirectly protects oligodendrocytes by modulating microglial polarization and reducing inflammatory responses

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2853-8.

HEK293 tau-BiFC cells

3 µM

48 hours

To evaluate the effect of Scriptaid on tau aggregation, results showed that Scriptaid significantly increased tau-BiFC fluorescence intensity, indicating increased tau aggregation.

Int J Mol Sci. 2019 Sep 1;20(17):4283.

CRL1790 cells

128.8 µM (IC50)

48 hours

Evaluate cytotoxic activity of Scriptaid in non-tumoral colon epithelial cells, results showed Scriptaid induced cytotoxicity

Open Biol. 2025 Feb;15(2):240183.

HCT116 cells

42.8 µM (IC50)

48 hours

Evaluate cytotoxic activity of Scriptaid in colorectal cancer cells, results showed Scriptaid induced cytotoxicity

Open Biol. 2025 Feb;15(2):240183.

HT29 cells

8.9 µM (IC50)

48 hours

Evaluate cytotoxic activity of Scriptaid in colorectal cancer cells, results showed Scriptaid induced cytotoxicity

Open Biol. 2025 Feb;15(2):240183.

SW480 cells

9.6 µM (IC50)

48 hours

Evaluate cytotoxic activity of Scriptaid in colorectal cancer cells, results showed Scriptaid induced cytotoxicity

Open Biol. 2025 Feb;15(2):240183.

U87 cells

3.2 µM

48 hours or 72 hours

To verify whether Scriptaid could enhance the inhibitory effect of temozolomide on U87 cell proliferation. Results showed that Scriptaid combined with temozolomide significantly inhibited U87 cell proliferation.

Front Immunol. 2025 Jan 21;15:1523034.

Primary microglia

1 µM

6 hours

Scriptaid modulated microglia polarization, reduced pro-inflammatory cytokine secretion, and protected oligodendrocytes from hemoglobin-induced injury.

J Cereb Blood Flow Metab. 2021 May;41(5):958-974.

Human breast CAFs (hCAFs)

10 µM

7 days

To study the reversal effect of Scriptaid on CAF marker expression. Results showed Scriptaid reduced the expression of SMA, fibronectin, col1, and palladin.

Br J Cancer. 2018 May;118(10):1359-1368.

Murine melanoma CAFs (mCAFs)

10 µM

7 days

To study the reversal effect of Scriptaid on CAF marker expression. Results showed Scriptaid reduced the expression of SMA, fibronectin, col1, and palladin.

Br J Cancer. 2018 May;118(10):1359-1368.

Scriptaid 动物实验

Species C57BL/6 J mice Mice C57BL/6 male mice C57BL/6J mice Mice Pigs	Animal Model Controlled cortical impact (CCI) model Traumatic brain injury model ICH model Vascular injury model B16F10 melanoma model SCNT embryo transfer model	Administration	Dosage	Frequency	Description	References
C57BL/6 J mice	Controlled cortical impact (CCI) model	Intraperitoneal injection	1.5 to 5.5 mg/kg	Administered at 30 minutes or 12 hours post-injury, continued for 3 days	Scriptaid, when administered at 30 minutes or 12 hours post-injury, significantly reduced lesion volume and attenuated motor and cognitive deficits. Additionally, Scriptaid modulated the PTEN and AKT pathways, increasing the number of surviving neurons and the number/length of their processes in the CA3 region of the hippocampus and the pericontusional cortex.	Neurotherapeutics. 2013 Jan;10(1):124-42
Mice	Traumatic brain injury model	Intraperitoneal injection	3.5 mg/kg	Injected at 2, 26, and 50 hours post-injury	Scriptaid protects white matter integrity by modulating microglial polarization and reducing inflammation	Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2853-8.
C57BL/6 male mice	ICH model	Intraperitoneal injection	3.5 mg/kg	Administered at 2, 26, and 50 hours post-ICH	Scriptaid improved neurological functional recovery, reduced white matter injury, and alleviated neuroinflammation by modulating microglia/macrophage polarization after ICH.	J Cereb Blood Flow Metab. 2021 May;41(5):958-974.
C57BL/6J mice	Vascular injury model	Intraperitoneal injection	3.5 μg/g	The day before injury, on the day of the injury, and every other day thereafter for 28 days	Reduced neointima formation and cyclin D1 expression following vascular injury	Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):851-60.
Mice	B16F10 melanoma model	Intraperitoneal injection	5.5 mg/kg	3 times per week until the end of the experiment	To study the effect of Scriptaid on tumor growth and CAF abundance. Results showed Scriptaid inhibited tumor growth by approximately twofold and significantly reduced the number of SMA+/Col1+ CAFs.	Br J Cancer. 2018 May;118(10):1359-1368.
Pigs	SCNT embryo transfer model	In vitro culture followed by transfer	500 nM Scriptaid + 100 µM DRB	Single treatment, lasting 15 hours	Evaluate the effect of combined Scriptaid and DRB treatment on SCNT embryo development, results showed combined treatment promoted normal fetal development and production of healthy cloned piglets.	Int J Mol Sci. 2022 Nov 16;23(22):14142.

Species

C57BL/6 J mice Mice C57BL/6 male mice C57BL/6J mice Mice Pigs

Animal Model

Controlled cortical impact (CCI) model Traumatic brain injury model ICH model Vascular injury model B16F10 melanoma model SCNT embryo transfer model

Administration

Dosage

Frequency

Description

References

C57BL/6 J mice

Controlled cortical impact (CCI) model

Intraperitoneal injection

1.5 to 5.5 mg/kg

Administered at 30 minutes or 12 hours post-injury, continued for 3 days

Scriptaid, when administered at 30 minutes or 12 hours post-injury, significantly reduced lesion volume and attenuated motor and cognitive deficits. Additionally, Scriptaid modulated the PTEN and AKT pathways, increasing the number of surviving neurons and the number/length of their processes in the CA3 region of the hippocampus and the pericontusional cortex.

Neurotherapeutics. 2013 Jan;10(1):124-42

Mice

Traumatic brain injury model

Intraperitoneal injection

3.5 mg/kg

Injected at 2, 26, and 50 hours post-injury

Scriptaid protects white matter integrity by modulating microglial polarization and reducing inflammation

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2853-8.

C57BL/6 male mice

ICH model

Intraperitoneal injection

3.5 mg/kg

Administered at 2, 26, and 50 hours post-ICH

Scriptaid improved neurological functional recovery, reduced white matter injury, and alleviated neuroinflammation by modulating microglia/macrophage polarization after ICH.

J Cereb Blood Flow Metab. 2021 May;41(5):958-974.

C57BL/6J mice

Vascular injury model

Intraperitoneal injection

3.5 μg/g

The day before injury, on the day of the injury, and every other day thereafter for 28 days

Reduced neointima formation and cyclin D1 expression following vascular injury

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):851-60.

Mice

B16F10 melanoma model

Intraperitoneal injection

5.5 mg/kg

3 times per week until the end of the experiment

To study the effect of Scriptaid on tumor growth and CAF abundance. Results showed Scriptaid inhibited tumor growth by approximately twofold and significantly reduced the number of SMA+/Col1+ CAFs.

Br J Cancer. 2018 May;118(10):1359-1368.

Pigs

SCNT embryo transfer model

In vitro culture followed by transfer

500 nM Scriptaid + 100 µM DRB

Single treatment, lasting 15 hours

Evaluate the effect of combined Scriptaid and DRB treatment on SCNT embryo development, results showed combined treatment promoted normal fetal development and production of healthy cloned piglets.

Int J Mol Sci. 2022 Nov 16;23(22):14142.

Scriptaid 参考文献

Scriptaid 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.32mL

3.06mL

1.53mL

30.64mL

6.13mL

3.06mL

Scriptaid 技术信息

CAS号	287383-59-9
分子式	C₁₈H₁₈N₂O₄
分子量	326.35
SMILES Code	O=C(NO)CCCCCN(C(C1=CC=CC2=CC=CC3=C12)=O)C3=O
MDL No.	MFCD00386477

别名	Scriptide; GCK1026
运输	蓝冰
InChI Key	JTDYUFSDZATMKU-UHFFFAOYSA-N
Pubchem ID	5186

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(321.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

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