Thiazovivin

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Chemical Structure| 1226056-71-8 同义名 : -
CAS号 : 1226056-71-8
货号 : A211276
分子式 : C15H13N5OS
纯度 : 98%
分子量 : 311.36
MDL号 : MFCD16495823
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(96.35 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • ROCK

    ROCK, IC50:~0.5 μM
描述 Thiazovivin (GMP) is produced in accordance with GMP guidelines. GMP-compliant small molecules are effective as auxiliary reagents in the manufacture of cell therapies. Thiazovivin is recognized as a potent ROCK inhibitor[1].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
HSMCs 1 μM Function Assay 2 h reverses AngII-induced MYPT1 phosphorylation 24965170
SCU-i10 hiPSCs 0-20 μM Growth Inhibition Assay 24 h significantly modulates single-cell plating efficiency and promote NCM growth 25077932
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.21mL

0.64mL

0.32mL

16.06mL

3.21mL

1.61mL

32.12mL

6.42mL

3.21mL
参考文献

[1]Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8129-34.

[2]Park S, et al. Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. Anim Reprod Sci. 2015 Oct;161:47-57.

[3]Cheng L, et al. Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol. Front Mol Neurosci. 2017 Oct 30;10:348.

[4]Kuo HH, et al. Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture. Stem Cell Reports. 2020 Feb 11;14(2):256-270.

[5]Lin T, et al. A chemical platform for improved induction of human iPSCs. Nat Methods. 2009 Nov;6(11):805-8.