Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
囊泡
/
抗感染
外泌体
/
3CLpro
艾滋病病毒 HIV蛋白酶
/ Saquinavir Mesylate/沙奎那韦甲磺酸盐

Saquinavir Mesylate/沙奎那韦甲磺酸盐 {[allProObj[0].p_purity_real_show]}

货号：A732241 同义名： 沙奎拉韦 / Ro 31-8959/003; Saquinavir (mesylate)

Saquinavir Mesylate 是 Saquinavir 的甲磺酸盐形式，是一种 HIV 蛋白酶抑制剂，兼具抑制 SARS-CoV-2 3CLpro 主蛋白酶活性，常用于抗病毒相关研究。

Saquinavir Mesylate/沙奎那韦甲磺酸盐 化学结构 CAS号：149845-06-7
Saquinavir Mesylate/沙奎那韦甲磺酸盐 化学结构
CAS号：149845-06-7
Saquinavir Mesylate/沙奎那韦甲磺酸盐 3D分子结构
CAS号：149845-06-7
Saquinavir Mesylate/沙奎那韦甲磺酸盐 化学结构 CAS号：149845-06-7
Saquinavir Mesylate/沙奎那韦甲磺酸盐 3D分子结构 CAS号：149845-06-7
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Saquinavir Mesylate/沙奎那韦甲磺酸盐 纯度/质量文件 产品仅供科研

货号：A732241 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 HIV Protease ↓ HIV-1 caspid ↓ 其他靶点 纯度
Dextran sulfate sodium salt(MW 40000) ✔ M.W 40000
Vicriviroc maleate ✔ 95%
Rosamultin ✔ 97%
Darunavir ✔ 98%
Lopinavir ++++

HIV protease, Ki: 1.3 pM

 		99+%
Chloroquine ✔ Autophagy 95%
Amprenavir +

HIV protease, IC50: 14.6 ng/mL

 		PXR 99%+
NBD-556 ✔ 99%+
Nelfinavir Mesylate +++

HIV protease, Ki: 2 nM

 		99%+
Atazanavir Sulfate ✔ 98%
Limonin ✔ 98%
Saquinavir ++

HIV proteinase, IC50: 2.7 nM

 		98%
Ritonavir ✔ 98%
Azvudine ✔ 98%
Lenacapavir ++++

HIV-1 capsid, EC50: 0.1 nM

 		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Saquinavir Mesylate/沙奎那韦甲磺酸盐 生物活性

描述 Saquinavir (SAQ) mesylate is a potent inhibitor of the HIV-1 protease indicated in combination with other antiretrovirals for the management of HIV-1 infection[3]. Saquinavir is an anti-retroviral drug with very low oral bioavailability (e.g. 0.7-4.0%) due to its affinity toward efflux transporters (P-gp) and metabolic enzymes (CYP3A4)[4]. As with other HIV protease inhibitors, saquinavir inhibits the cleavage of the gag-pol protein substrate leading to the release of structurally defective and functionally inactive viral particles. It is active on both HIV-1 and HIV-2, and also has activity on chronically infected cells and HIV strains resistant to reverse transcriptase inhibitors. Saquinavir is characterised by a low bioavailability which is further reduced in the fasting state. Because of its metabolic interference with the CYP system, saquinavir cannot be coadministered with astemizole, terfenadine or cisapride. Saquinavir is generally well tolerated, with mild gastrointestinal symptoms representing the most commonly observed adverse effects[5].

Saquinavir Mesylate/沙奎那韦甲磺酸盐 细胞实验

Cell Line
Concentration Treated Time Description References
CEM-T4 cells 5 µM 7 days To prevent HIV spreading and permit cells to revert to latency Nat Med. 2016 Jul;22(7):807-11.
tonsil-derived CD4 T cells 5μM 48 h To evaluate the killing efficiency of cCAR-T cells against HIV-infected tonsil-derived CD4 T cells, results showed that killing efficiency increased with the number of effector cells. Cell. 2019 Oct 31;179(4):880-894.e10.
PC3 cells 10 μM 24 h To evaluate the cytotoxicity of Saquinavir on PC3 cells, results showed that Saquinavir significantly reduced the viability of PC3 cells Cell Death Dis. 2022 Mar 19;13(3):252.
LASCPC01 cells 10 μM 24 h To evaluate the cytotoxicity of Saquinavir on LASCPC01 cells, results showed that Saquinavir significantly reduced the viability of LASCPC01 cells Cell Death Dis. 2022 Mar 19;13(3):252.
resting CD4 T cells 1.25 µM 3 days To study the expression of HIV Gag protein in directly infected resting CD4 T cells, and it was found that Gag/H11001 cells lacked surface CD4, indicating these cells expressed multiple viral proteins. J Virol. 2015 Nov 4;90(5):2165-79.

Saquinavir Mesylate/沙奎那韦甲磺酸盐 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Macaques SIV infection model Oral 205 mg/kg Twice daily until necropsy To study the antiviral effects of Saquinavir in the SIV-infected macaque model Ann Neurol. 2011 Jan;69(1):100-10
Albino male rabbits Albino male rabbits Oral and intranasal administration 15 mg/kg To evaluate the pharmacokinetic parameters of the SQ-cubosomal thermogelling formulation, the results showed that the relative bioavailability of the intranasal thermogelling formulation was 12-fold higher compared to the oral aqueous suspension and 2.5-fold higher compared to the intranasal aqueous suspension. Int J Nanomedicine. 2020 Jul 16;15:5113-5129
Mice LASCPC01 and C4-2-MDVR xenograft model Intraperitoneal injection 25 mg/kg Twice a week for 4 weeks To evaluate the tumor growth inhibitory effect of Saquinavir on LASCPC01 and C4-2-MDVR xenografts, results showed that Saquinavir significantly inhibited tumor growth Cell Death Dis. 2022 Mar 19;13(3):252.

Saquinavir Mesylate/沙奎那韦甲磺酸盐 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00035932 HIV Infections Phase 3 Completed - -
NCT00197145 Infection, Human Immunodeficie... 展开 >>ncy Virus I 收起 << Phase 3 Terminated - -
NCT00197145 - Terminated - -

Saquinavir Mesylate/沙奎那韦甲磺酸盐 参考文献

[1]Branham ML, Moyo T, et al. Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement. Eur J Pharm Biopharm. 2012 Jan;80(1):194-202.

[2]Yerino GA, Halabe EK, et al. Bioequivalence study of two oral tablet formulations containing saquinavir mesylate boosted with ritonavir in healthy male subjects. Arzneimittelforschung. 2011;61(8):481-7.

[3]Yerino GA, Halabe EK, Zini E, Feleder EC. Bioequivalence study of two oral tablet formulations containing saquinavir mesylate boosted with ritonavir in healthy male subjects. Arzneimittelforschung. 2011;61(8):481-7

[4]Branham ML, Moyo T, Govender T. Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement. Eur J Pharm Biopharm. 2012 Jan;80(1):194-202

[5]Vella S, Floridia M. Saquinavir. Clinical pharmacology and efficacy. Clin Pharmacokinet. 1998 Mar;34(3):189-201

Saquinavir Mesylate/沙奎那韦甲磺酸盐 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.30mL

0.26mL

0.13mL

6.52mL

1.30mL

0.65mL

13.04mL

2.61mL

1.30mL

Saquinavir Mesylate/沙奎那韦甲磺酸盐 技术信息

CAS号149845-06-7
分子式C39H54N6O8S
分子量 766.95
SMILES Code CS(=O)(O)=O.O=C(C1=NC2=C(C=CC=C2)C=C1)N[C@@H](CC(N)=O)C(N[C@@H](CC3=CC=CC=C3)[C@H](O)CN4[C@@H](C[C@@]5([H])[C@@](CCCC5)([H])C4)C(NC(C)(C)C)=O)=O
MDL No. MFCD00944907
别名 沙奎拉韦 ;Ro 31-8959/003; Saquinavir (mesylate)
运输蓝冰
InChI Key IRHXGOXEBNJUSN-YOXDLBRISA-N
Pubchem ID 60934
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C
溶解方案

DMSO: 16 mg/mL(20.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Saquinavir | 149845-06-7 | Ro 31-8959/003 | HIV Protease Inhibitor | Anti-infection | Metabolic Enzyme/Protease | Autophagy | HIV | HIV Protease | Autophagy | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Saquinavir Mesylate/沙奎那韦甲磺酸盐 纯度/质量文件 | Saquinavir Mesylate/沙奎那韦甲磺酸盐 亚型比较 | Saquinavir Mesylate/沙奎那韦甲磺酸盐 生物活性 | Saquinavir Mesylate/沙奎那韦甲磺酸盐 临床数据 | Saquinavir Mesylate/沙奎那韦甲磺酸盐 参考文献 | Saquinavir Mesylate/沙奎那韦甲磺酸盐 实验方案 | Saquinavir Mesylate/沙奎那韦甲磺酸盐 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z