Lenacapavir
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货号：A1194685
同义名：
GS-6207
Lenacapavir是一种新型的HIV-1衣壳抑制剂，能够有效抑制HIV病毒的复制，是HIV感染治疗研究的重要工具。
Lenacapavir 化学结构
Lenacapavir 3D分子结构
规格
价格
会员价
库存
数量
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Lenacapavir 纯度/质量文件 产品仅供科研
货号：A1194685
标准纯度：
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产品说明书
全球学术期刊中引用的产品
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Lenacapavir 质控信息
Lenacapavir 生物活性
Lenacapavir 细胞实验
Cell Line
Concentration
Treated Time
Description
References
pigtail macaque PBMCs
pigtail macaque PBMCs
Evaluate the inhibitory effect of Lenacapavir on stHIV-A19 in pigtail macaque PBMCs
EBioMedicine. 2023 Sep;95:104764.
human PBMCs
human PBMCs
Evaluate the inhibitory effect of Lenacapavir on stHIV-A19 in human PBMCs
EBioMedicine. 2023 Sep;95:104764.
SupT1-CCR5 cells
SupT1-CCR5 cells
Evaluate the inhibitory effect of Lenacapavir on stHIV-A19, showing comparable efficacy to HIV-1 NL4-3
EBioMedicine. 2023 Sep;95:104764.
rhesus PBMCs
rhesus PBMCs
To evaluate the in vitro antiviral activity of Lenacapavir against SHIV, showing potent inhibition.
J Clin Invest. 2023 Aug 15;133(16):e167818.
TZM-bl cells
TZM-bl cells
Determine antiviral potency of LEN at the lowest p24 levels, EC50 was 60 pM
PLoS Pathog. 2025 Jan 27;21(1):e1012862.
Jurkat/Vpr-HiBiT T cells
Jurkat/Vpr-HiBiT T cells
Screened compounds inhibiting HIV-1 release, identified 10 candidate compounds
J Biol Chem. 2024 Sep;300(9):107701.
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Lenacapavir 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Pigtail macaques
StHIV-A19 infection model
Subcutaneous injection
25 mg/kg
Single injection, virus challenge after 30 days
Evaluate the preventive effect of Lenacapavir against stHIV-A19 in pigtail macaques, showing all treated animals were protected from infection
EBioMedicine. 2023 Sep;95:104764.
Rhesus macaques
SHIV rectal challenge model
Subcutaneous injection
5-75 mg/kg
Single dose, monitored up to 25 weeks
To evaluate the pharmacokinetic profile and prophylactic efficacy of Lenacapavir in rhesus macaques. Results showed long plasma half-life and complete protection against SHIV infection when plasma drug concentrations exceeded 70 nM.
J Clin Invest. 2023 Aug 15;133(16):e167818.
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Lenacapavir 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.03mL
0.21mL
0.10mL
5.16mL
1.03mL
0.52mL
10.33mL
2.07mL
1.03mL
Lenacapavir 技术信息
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