Human immunodeficiency virus type 1 (HIV-1) protease specifically processes gag (p55) and gag-pol (p160) viral polyproteins to yield the viral structural proteins (p17, p24, p7, and p6)[3]. Atazanavir Sulfate (BMS-232632 Sulfate) is a protease inhibitor used to treat and prevent HIV/AIDS. Atazanavir is an azapeptide HIV-1 protease inhibitor that exhibits potent anti-HIV activity with EC50 of 2.6 to 5.3 nM and EC90 of 9 to 15 nM in cell culture[3]. Atazanavir/ritonavir (300/100 mg once daily) inhibited glucose uptake in vitro significantly less than lopinavir/ritonavir (400/100 mg twice daily) for 10 day[4]. In clinical trial, mean reductions from baseline in plasma HIV RNA levels in antiretroviral therapy-naive patients were not significantly different between once-daily atazanavir 400mg and two- or three-times daily nelfinavi or once-daily efavirenz[5]. After 21 days of treatment with atazanavir sulfate plus ritonavir (30 + 10 mg/kg) in Bleomycin (BLM)-induced pulmonary fibrosis model, the BLM-induced pathology score was reduced by 51.0%, and increase in collagen contents and Hyp content were also decreased compared with the BLM group[6]. In myocardial infarction (MI)-induced cardiac fibrosis rats, intragastric administration of atazanavir sulfate 30 mg/k ameliorated changes in the left ventricular systolic pressure (LVSP), + dp/dtmax, and - dp/dtmax after 4 weeks[7]. Recently, it is reported that Atazanavir showed anti-2019-novel coronavirus activity.
Atazanavir Sulfate/阿扎那韦硫酸盐 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Bovine cardiac myocytes
70–21,120 ng/mL
2 hours
Enhanced RyR2 open probability
Int J Mol Sci. 2022 Dec 23;24(1):274.
Whole blood
0, 1, 5, 10 µM
24 hours
To assess the effect of atazanavir on LPS-induced cytokine release. Results showed that atazanavir did not influence the release of TNF-α or IL-10.
Front Immunol. 2023 May 16;14:1176775.
Human primary monocytes
1 µM and 10 µM
24 hours
To evaluate the effects of ATV and ATV/RTV on viral replication, cell death, and inflammatory mediator release in SARS-CoV-2-infected monocytes. Results showed ATV and ATV/RTV significantly reduced viral RNA levels, cell death, and IL-6 and TNF-α release.
To evaluate the effect of Atazanavir on intracellular calcium homeostasis in skeletal muscle cells, results showed that ATV induced Ca2+ transients and mobilized Ca2+ from the SR via activation of RyR1.
Antiviral Res. 2021 Mar;187:104975.
Candida auris AR0390
16 mg/mL
48 hours
To evaluate the killing kinetics of atazanavir in combination with itraconazole, showing significant reduction in fungal burden.
Antimicrob Agents Chemother. 2023 May 17;67(5):e0163122.
A549 cells
0.22 µM
48 hours
To evaluate the inhibitory effects of ATV and ATV/RTV on SARS-CoV-2 replication in human lung epithelial cells. Results showed ATV had an EC50 of 0.22 μM in A549 cells, more potent than in Vero cells.
To evaluate the inhibitory effects of ATV and ATV/RTV on SARS-CoV-2 replication. Results showed ATV/RTV was more effective than ATV, with EC50 values of 0.5 μM and 2.0 μM, respectively.
Spain
... 展开 >> Hospital de Elche
Elche, Alicante, Spain
Hospital Marina Baixa
Villajoyosa, Alicante, Spain
H. Germans Trias i Pujol
Badalona, Barcelona, Spain
Hospital General de Granollers
Granollers, Barcelona, Spain
Hospital de Jerez
Jerez de la Frontera, Cádiz, Spain
Complexo Hospitalario Universitario de Santiago
Santiago de Compostela, La Coruña, Spain
H. San Pedro
Logroño, La Rioja, Spain
Hospital Príncipe de Asturias
Alcalá de Henares, Madrid, Spain
Hospital Severo Ochoa
Leganés, Madrid, Spain
Hospital Costa del Sol
Marbella, Málaga, Spain
Hospital Arquitecto Marcide
El Ferrol, Pontevedra, Spain
Hospital Xeral Cíes
Vigo, Pontevedra, Spain
Hospital de Basurto
Basurto, Vizcaya, Spain
Hospital General de Alicante
Alicante, Spain
H. Universitario Central de Asturias
Asturias, Spain
Hospital Santa Creu i Sant Pau
Barcelona, Spain
Hospital Vall d'Hebrón
Barcelona, Spain
Hospital Reina Sofía
Córdoba, Spain
Hospital Clínico San Cecilio
Granada, Spain
Hospital Virgen de las Nieves
Granada, Spain
H. Juan Ramón Jiménez
Huelva, Spain
Hospital Juan Canalejo
La Coruña, Spain
H. Clinico San Carlos
Madrid, Spain
H. Universitario Infanta Leonor
Madrid, Spain
Hospital Doce de Octubre
Madrid, Spain
Hospital Gregorio Marañón
Madrid, Spain
Hospital La Paz
Madrid, Spain
Hospital Ramón y Cajal
Madrid, Spain
H. Universitario Son Espases
Mallorca, Spain
Hospital de Mataró
Mataró, Spain
Hospital Virgen de la Victoria
Málaga, Spain
Hospital de Navarra
Pamplona, Spain
Hospital Donostia
San Sebastián, Spain
Hospital Marqués de Valdecilla
Santander, Spain
Hospital de Santa Tecla
Tarragona, Spain
Hospital La Fe
Valencia, Spain 收起 <<
United States, California
... 展开 >>
1100.1512.28 Boehringer Ingelheim Investigational Site
Beverly Hills, California, United States
1100.1512.20 Boehringer Ingelheim Investigational Site
Los Angeles, California, United States
United States, Colorado
1100.1512.15 Boehringer Ingelheim Investigational Site
Denver, Colorado, United States
United States, District of Columbia
1100.1512.26 Boehringer Ingelheim Investigational Site
Washington, District of Columbia, United States
United States, Florida
1100.1512.17 Boehringer Ingelheim Investigational Site
Fort Lauderdale, Florida, United States
1100.1512.14 Boehringer Ingelheim Investigational Site
Orlando, Florida, United States
1100.1512.23 Boehringer Ingelheim Investigational Site
Vero Beach, Florida, United States
United States, Illinois
1100.1512.29 Boehringer Ingelheim Investigational Site
Maywood, Illinois, United States
United States, New Jersey
1100.1512.11 Boehringer Ingelheim Investigational Site
Neptune, New Jersey, United States
1100.1512.25 Boehringer Ingelheim Investigational Site
Newark, New Jersey, United States
1100.1512.18 Boehringer Ingelheim Investigational Site
Somers Point, New Jersey, United States
United States, North Carolina
1100.1512.22 Boehringer Ingelheim Investigational Site
Winston-Salem, North Carolina, United States
United States, Pennsylvania
1100.1512.21 Boehringer Ingelheim Investigational Site
Philadelphia, Pennsylvania, United States
United States, South Carolina
1100.1512.13 Boehringer Ingelheim Investigational Site
Charleston, South Carolina, United States
United States, Texas
1100.1512.30 Boehringer Ingelheim Investigational Site
Dallas, Texas, United States
1100.1512.19 Boehringer Ingelheim Investigational Site
Fort Worth, Texas, United States
1100.1512.16 Boehringer Ingelheim Investigational Site
Houston, Texas, United States
1100.1512.24 Boehringer Ingelheim Investigational Site
Houston, Texas, United States
United States, Virginia
1100.1512.27 Boehringer Ingelheim Investigational Site
Annandale, Virginia, United States 收起 <<
United States, District of Col... 展开 >>umbia
Whitman-Walker Clinic
Recruiting
Washington, District of Columbia, United States
Contact: Richard Elion, MD drrelion@aol.com
Principal Investigator: Richard A Elion, MD 收起 <<
United States, Arizona
... 展开 >>
Local Institution
Phoenix, Arizona, United States
United States, California
Local Institution
Bakersfield, California, United States
Local Institution
Los Angeles, California, United States
Local Institution
San Francisco, California, United States
United States, Florida
Local Institution
Miami, Florida, United States
United States, Massachusetts
Local Institution
Boston, Massachusetts, United States
United States, New York
Local Institution
New York, New York, United States
United States, Ohio
Local Institution
Cincinnati, Ohio, United States
United States, Oregon
Local Institution
Portland, Oregon, United States
United States, Pennsylvania
Local Institution
Philadelphia, Pennsylvania, United States
United States, South Carolina
Local Institution
Columbia, South Carolina, United States
United States, Texas
Local Institution
Dallas, Texas, United States
Canada, Ontario
Local Institution
Hamilton, Ontario, Canada
Canada, Quebec
Local Institution
Montreal, Quebec, Canada 收起 <<
United States, California
... 展开 >>
Stanford AIDS Clinical Trials Unit CRS
Palo Alto, California, United States, 94304-5350
United States, Colorado
University of Colorado Hospital CRS
Aurora, Colorado, United States, 80045
United States, Hawaii
Univ. of Hawaii at Manoa, Leahi Hosp.
Honolulu, Hawaii, United States, 96816
United States, Iowa
Univ. of Iowa Healthcare, Div. of Infectious Diseases
Iowa City, Iowa, United States, 52242
United States, Nebraska
Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr.
Omaha, Nebraska, United States, 68198-9500
United States, New York
Weill Cornell Chelsea CRS
New York, New York, United States, 10011
United States, North Carolina
Chapel Hill CRS
Chapel Hill, North Carolina, United States, 27599
Duke Univ. Med. Ctr. Adult CRS
Durham, North Carolina, United States, 27710
United States, Ohio
Cincinnati CRS
Cincinnati, Ohio, United States, 45219
United States, Pennsylvania
University of Pittsburgh CRS
Pittsburgh, Pennsylvania, United States, 15213
United States, Texas
Dallas VAMC
Dallas, Texas, United States, 75216
Puerto Rico
Puerto Rico AIDS Clinical Trials Unit CRS
San Juan, Puerto Rico, 00935 收起 <<
United States, California
... 展开 >>
Los Angeles, California, United States
United States, Connecticut
Glastonbury, Connecticut, United States
United States, District of Columbia
Washington, District of Columbia, United States
United States, Florida
Fort Lauderdale, Florida, United States
Miami, Florida, United States
Orlando, Florida, United States
United States, Indiana
Indianapolis, Indiana, United States
United States, Massachusetts
Boston, Massachusetts, United States
United States, Minnesota
Minneapolis, Minnesota, United States
United States, Missouri
Saint Louis, Missouri, United States
United States, New Jersey
Hillsborough, New Jersey, United States
United States, New York
New York, New York, United States
United States, Ohio
Cincinnati, Ohio, United States
United States, Pennsylvania
Philadelphia, Pennsylvania, United States
United States, Texas
Dallas, Texas, United States 收起 <<
United States, California
... 展开 >>
Local Institution
San Francisco, California, United States
United States, District of Columbia
Local Institution
Washington, District of Columbia, United States
United States, Florida
Local Institution
Atlantis, Florida, United States
Local Institution
Orlando, Florida, United States
Local Institution
South Miami, Florida, United States
Local Institution
Tampa, Florida, United States
United States, Louisiana
Local Institution
New Orleans, Louisiana, United States
United States, Massachusetts
Local Institution
Boston, Massachusetts, United States
United States, Michigan
Local Institution
Berkley, Michigan, United States
United States, Missouri
Local Institution
St. Louis, Missouri, United States
United States, North Carolina
Local Institution
Huntersville, North Carolina, United States
United States, South Carolina
Local Institution
Clumbia, South Carolina, United States
United States, Texas
Local Institution
Austin, Texas, United States
Local Institution
Dallas, Texas, United States
United States, Virginia
Local Institution
Hampton, Virginia, United States 收起 <<
United States, Arizona
... 展开 >>
Local Institution
Phoenix, Arizona, United States
United States, California
Local Institution
West Hollywood, California, United States
United States, District of Columbia
Local Institution
Washington, District of Columbia, United States
United States, Florida
Local Institution
Altamonte Springs, Florida, United States
Local Institution
Ft. Lauderdale, Florida, United States
Local Institution
Miami, Florida, United States
Local Institution
Tampa, Florida, United States
United States, Massachusetts
Local Institution
Boston, Massachusetts, United States
United States, Minnesota
Local Institution
Minneapolis, Minnesota, United States
United States, Missouri
Local Institution
St. Louis, Missouri, United States
United States, New Jersey
Local Institution
East Orange, New Jersey, United States
United States, New York
Local Institution
New York, New York, United States
United States, North Carolina
Local Institution
Huntersville, North Carolina, United States
United States, Ohio
Local Institution
Cleveland, Ohio, United States
United States, Oklahoma
Local Institution
Oklahoma City, Oklahoma, United States
United States, Pennsylvania
Local Institution
Philadelphia, Pennsylvania, United States
United States, South Carolina
Local Institution
Columbia, South Carolina, United States
United States, Texas
Local Institution
Fort Worth, Texas, United States
Local Institution
Houston, Texas, United States 收起 <<
France
... 展开 >> Local Institution
Bobigny, France, 93009
Local Institution
Le Kremlin Bicetre, France, 94270
Local Institution
Paris Cedex 15, France, 75908
Local Institution
Paris Cedex 20, France, 75970
Local Institution
Paris, France, 75651
Local Institution
Paris, France, 75877 收起 <<
United States, New Jersey
... 展开 >>
Garden State Infectious Disease Associates, Pa
Voorhees, New Jersey, United States, 08043
United States, North Carolina
Unc Center For Aids Research
Chapel-Hill, North Carolina, United States, 27599
United States, Pennsylvania
Local Institution
Philadelphia, Pennsylvania, United States, 19104
United Kingdom
Local Institution
London, Greater London, United Kingdom, SW10 9TH 收起 <<
France
... 展开 >> Hopital du Kremlin Bicêtre Service de médecine interne
Kremlin Bicëtre, France, 94275
Hopital Bichat CIC
Paris cedex 18, France, 75877 收起 <<
Germany
... 展开 >> University of Bonn
Bonn, Germany
Netherlands
Rijnstate Hospital Arnhem
Arnhem, Netherlands
Radboud University Medical Centre Nijmegen
Nijmegen, Netherlands
Erasmus Medical Center Rotterdam
Rotterdam, Netherlands 收起 <<
United States, California
... 展开 >>
Local Institution
Pomona, California, United States
United States, Washington
Local Institution
Seattle, Washington, United States
United Kingdom
Local Institution
London, Greater London, United Kingdom 收起 <<
Estonia
... 展开 >> Local Institution
Tallinn, Estonia
France
Local Institution
Le Kremlin Bicetre 94, France
Local Institution
Orleans, France
Local Institution
Paris Cedex 12, France
Local Institution
Paris Cedex 20, France
Local Institution
Paris, France
Local Institution
Suresnes, France
Germany
Local Institution
Dusseldorf, Germany
Local Institution
Hannover, Germany
Local Institution
Stuttgart, Germany
Local Institution
Ulm, Germany
Ireland
Local Institution
Dublin 3, Dublin, Ireland
Local Institution
Dublin 8, Dublin, Ireland
Italy
Local Institution
Brescia, Italy
Local Institution
Milano, Italy
Local Institution
Napoli, Italy
Local Institution
Padova, Italy
Latvia
Local Institution
Riga, Latvia
Portugal
Local Institution
Cascais, Portugal
Local Institution
Porto, Portugal
Russian Federation
Local Institution
Moscow, Russian Federation
Local Institution
Smolensk, Russian Federation
Local Institution
St. Petersburg, Russian Federation
Spain
Local Institution
Elche, Alicante, Spain
Local Institution
Barcelona, Spain
Local Institution
Madrid, Spain
Local Institution
Valencia, Spain
United Kingdom
Local Institution
Bristol, Avon, United Kingdom
Local Institution
Edinburgh, Central, United Kingdom
Local Institution
London, Greater London, United Kingdom 收起 <<
United States, Arizona
... 展开 >>
Spectrum Medical Group
Phoenix, Arizona, United States, 85012
United States, California
AIDS Healthcare Foundation
Los Angeles, California, United States, 90028
United States, Colorado
Denver Public Health
Denver, Colorado, United States, 80204
United States, District of Columbia
Whitman-Walker Clinic
Washington, D.C., District of Columbia, United States, 20009
United States, Florida
Orlando Immunology Center
Orlando, Florida, United States, 32803
Treasure Coast Infectious Disease Consultants
Vero Beach, Florida, United States, 32960
United States, Kansas
Christi Research
Wichita, Kansas, United States, 67214
United States, Massachusetts
Community Research Initiative of New England - Boston
Boston, Massachusetts, United States, 02215
United States, Texas
David M. Lee, MD, PA d/b/a/ Uptown Physicians' Group
Dallas, Texas, United States, 75804 收起 <<
Korea, Republic of
... 展开 >>
Asan Medical Center
Not yet recruiting
Songpa-gu, Seoul, Korea, Republic of, 138-736
Contact: Kyun-Seop Bae, M.D., Ph. D. 82-2-3010-4622 收起 <<
South Africa
... 展开 >> Tshepang clinic, Limpopo University
Pretoria, South Africa
Tanzania
NIMR-Mbeya Medical Research Program-Mbeya Referral Hospital
Mbeya, Tanzania 收起 <<
Belgium
... 展开 >> Hospital St Pierre
Brussels, Belgium
Germany
German Competence Network
Frankfurt, Germany
Italy
Italian Register for HIV-infection in Children
Florence, Italy
Romania
Victor Babes Hospital
Bucharest, Romania
Spain
Spanish Perinatal Cohort
Barcelona, Spain
Madrid Paediatric HIV Cohort
Madrid, Spain
Switzerland
Swiss Mother and Child HIV Cohort
Basel, Switzerland
United Kingdom
Collaborative HIV Paediatric Study
London, United Kingdom
European Collaborative Study
London, United Kingdom 收起 <<
United States, Florida
... 展开 >>
Triple O Medical Services, P.A.
West Palm Beach, Florida, United States, 33401
United States, Texas
Women's Hospital Of Texas
Houston, Texas, United States, 77054
Puerto Rico
Local Institution
San Juan, Puerto Rico, 00936
South Africa
Local Institution
Soweto, Gauteng, South Africa, 2001
Local Institution
Sunnyside, Gauteng, South Africa, 0002
Local Institution
Westdene, Gauteng, South Africa, 2092 收起 <<
Terminated(Efficacy endpoint m... 展开 >>et, but overall experimental dosing regimen not considered optimal to support further clinical development in this population.) 收起 <<
-
United States, Arizona
... 展开 >>
Southwest Center For HIV/AIDS
Phoenix, Arizona, United States, 85006
United States, Connecticut
Yale University School Of Medicine
New Haven, Connecticut, United States, 06510
United States, District of Columbia
Dupont Circle Physicians Group
Washington, District of Columbia, United States, 20009
United States, Florida
Orlando Immunology Center
Orlando, Florida, United States, 32803
United States, New York
The Aaron Diamond AIDS Research Center
New York, New York, United States, 10016
United States, Ohio
University Of Cincinnati
Cincinnati, Ohio, United States, 45267
United States, Texas
Tarrant County Infectious Disease Associates
Ft Worth, Texas, United States, 76104
Therapeutic Concepts, P.A.
Houston, Texas, United States, 77004
Diversified Medical Practices, P.A.
Houston, Texas, United States, 77057
Argentina
Local Institution
Buenos Aires, Bs As, Buenos Aires, Argentina, 1141
Local Institution
Capital Federal, Buenos Aires, Argentina, 1264
Local Institution
Mar Del Plata, Buenos Aires, Argentina, B7600CTO
Local Institution
Rosario, Santa Fe, Argentina, 2000
France
Local Institution
Nantes Cedex 01, France, 44035
Local Institution
Paris Cedex 10, France, 75475
Local Institution
Paris Cedex 20, France, 75970 收起 <<
Terminated(Efficacy endpoint m... 展开 >>et, but overall experimental dosing regimen not considered optimal to support further clinical development in this population.) 收起 <<
Human Immunodeficiency Virus T... 展开 >>ype 1 (HIV-1)
HIV Infections 收起 <<
Phase 1
Completed
-
United States, California
... 展开 >>
West Coast Clinical Trials, Llc
Cypress, California, United States, 90630
Netherlands
Local Institution
Nijmegen, Netherlands, 6425 GA 收起 <<
Brazil
... 展开 >> Local Institution
Sao Paolo, SAO Paulo, Brazil, 01246-900
Chile
Local Institution
Santiago, Metropolitana, Chile, 8380418
Local Institution
Santiago, Metropolitana, Chile
Mexico
Local Institution
Df, Distrito Federal, Mexico, 06720
Local Institution
Guadalajara, Jalisco, Mexico, 44160
Local Institution
Guadalajara, Jalisco, Mexico, 44280
Local Institution
Merida, Yucatan, Mexico, 97000
Local Institution
Oaxaca, Mexico, 71256
Local Institution
Puebla, Mexico, 72000
Peru
Local Institution
Lima, Peru, 1
Local Institution
Lima, Peru
South Africa
Local Institution
Bloemfontein, FREE State, South Africa, 9301
Local Institution
Coronationville, Gauteng, South Africa, 2092
Local Institution
Soweto, Gauteng, South Africa, 2001
Local Institution
Congella, KWA ZULU Natal, South Africa, 4013
Local Institution
Cape Town, Western CAPE, South Africa, 7505
Thailand
Local Institution
Bangkok, Thailand, 10330
Local Institution
Bangkok, Thailand, 10700 收起 <<
United States, Arizona
... 展开 >>
Phoenix Children'S Hospital
Phoenix, Arizona, United States, 85016
United States, Georgia
Grady Health System Ponce Family And Youth Clinic
Atlanta, Georgia, United States, 30322
United States, Texas
Children'S Medical Center Of Dallas
Dallas, Texas, United States, 75235
Argentina
Local Institution
Buenos Aires, Bs As, Buenos Aires, Argentina, 1141
Local Institution
Buenos Aires, Argentina, 1181
Local Institution
Buenos Aires, Argentina, 1425
Brazil
Local Institution
Salvador, Bahia, Brazil, 40110-160
Local Institution
Salvador, Bahia, Brazil, 40110
Local Institution
Porto Alegre, RIO Grande DO SUL, Brazil, 90035-903
Local Institution
Porto Alegre, Rio Grande Do Sul, Brazil, 90035
Local Institution
Sao Paulo, SP, Brazil, 01416-901
Local Institution
Sao Paulo, Brazil, 01246
Chile
Local Institution
Santiago, Metropolitana, Chile, 8207257
Local Institution
Santiago, Metropolitana, Chile, 8380418
Mexico
Local Institution
Guadalajara, Jalisco, Mexico, 44280
Local Institution
Monterrey, Nuevo LEON, Mexico, 64000
Local Institution
Merida, Yucatan, Mexico, 97000
Local Institution
Puebla, Mexico, 72000
Peru
Local Institution
Lima, Peru, 1
Local Institution
Lima, Peru, LIMA 10
Russian Federation
Local Institution
Moscow, Russian Federation, 129110
Local Institution
St. Petersburg, Russian Federation, 190103
South Africa
Local Institution
Port Elizabeth, Eastern CAPE, South Africa, 6001
Local Institution
Bloemfontein, FREE State, South Africa, 9301
Local Institution
Soweto, Gauteng, South Africa, 2013
Local Institution
Cape Town, Western CAPE, South Africa, 7505
Local Institution
Cape Town, Western CAPE, South Africa, 7530 收起 <<
Australia, New South Wales
... 展开 >>
Holdsworth House Medical Practice
Sydney, New South Wales, Australia, 2010
St Vincent's Hospital
Sydney, New South Wales, Australia, 2010 收起 <<
France
... 展开 >> Hopital Zobda Quitman
Fort De France, Martinique, France, 97261
Centre Hospitalier D'Argenteuil
Argenteuil, France, 95107
Hopital Saint-Jacques
Besancon, France, 25000
Hopital Avicenne
Bobigny, France, 93000
Hopital Jean Verdier
Bondy, France, 93143
Hopital Saint-Andre
Bordeaux, France, 33075
Chu Cote de Nacre
Caen, France, 14033
Hopital Louis Mourier
Colombes, France, 92700
Hopital Le Bocage
Dijon, France, 21034
Hopital Raymond Poincare
Garches, France, 92380
C.H.D de Vendee
La Roche Sur Yon, France, 85925
Hopital Dupuytren
Limoges, France, 87000
Hopital Sainte-Marguerite
Marseille, France, 13274
Centre Hospitalier de Melun
Melun, France, 77011
Hopital L'Archet
Nice, France, 06202
Hopital Lariboisiere
Paris, France, 75010
Hopital Saint Antoine
Paris, France, 75012
Hopital Pitie-Salpetriere
Paris, France, 75013
Hopital Necker
Paris, France, 75015
Hopital Bichat
Paris, France, 75018
Hopital Tenon
Paris, France, 75020
Hopital Pitie-Salpetriere
Paris, France, 75651
Hopital Cochin
Paris, France, 75674
Hopital Europeen Georges Pompidou
Paris, France, 75908
Hopital Saint-Jean Roussillon
Perpignan, France, 66046
Hopital Rene Dubos
Pontoise, France, 95303
C.H.R.A
Pringy, France, 74374
Hopital Civil
Strasbourg, France, 67000
Hopital Gustave Dron
Tourcoing, France, 59208
Hopital Bretonneau
Tours, France, 37044 收起 <<
United States, California
... 展开 >>
University of California
San Diego, California, United States, 92103
United States, Illinois
Northwestern Universtiy
Chicago, Illinois, United States, 60611
United States, Indiana
Indiana University
Indianapolis, Indiana, United States, 46202
United States, Ohio
University of Cincinnati
Cincinnati, Ohio, United States, 45267
United States, Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53792
Argentina
ACLIRES - Argentina S.R.L.
Buenos Aires, Argentina
Italy
Universita degli studi di Modena e Reggio Emilia
Modena, Italy 收起 <<
Terminated(due to introduction... 展开 >> of another integrase inhibitor, recruitement was not feasible anymore.) 收起 <<
-
Germany
... 展开 >> University of Bonn
Bonn, Germany
Netherlands
Rijstate
Arnhem, Netherlands
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands
St. Elisabeth
Tilburg, Netherlands 收起 <<
Italy
... 展开 >> Ospedale S. M. Annunziata - U.O. Malattie Infettive
Bagno a Ripoli, Firenze, Italy, 50011
P.O. "S. Caterina Novella" - UOC di Malattie Infettive
Galatina, Lecce, Italy, 73013
Azienda Ospedaliero Universitaria - Ospedali Riuniti di Ancona Struttura Organizzativa Dipartimentale (S.O.D) Clinica di Malattie infettive
Ancona, Italy, 60126
Azienda Ospedaliera Spedali Civili - Istituto di Malattie Infettive e Tropicali
Brescia, Italy, 25123
Azienda Ospedaliera di Rilievo Nazionale di alta specializzazione Garibaldi di Catania - Istituto Malattie infettive
Catania, Italy, 95122
Azienda Ospedaliera Universitaria San Martino - Clinica Malattie Infettive
Genova, Italy, 16132
A.O. Ospedale Niguarda Cà Granda - Malattie Infettive
Milano, Italy, 20126
Ospedale San Raffaele
Milano, Italy, 20127
Ospedale Luigi Sacco di Milano - Malattie infettive I Divisione
Milano, Italy, 20157
Ospedale Luigi Sacco di Milano Azienda ospedaliera e Polo Universitario - Dip. di Scienze Cliniche L. Sacco / Sez. Malattie Infettive
Milano, Italy, 20157
A.O. Universitaria Policlinico Paolo Giaccone di Palermo - Malattie Infettive
Palermo, Italy, 9127
Ospedale S. Maria della Misericordia
Perugia, Italy, 06129
IRCCS Istituto Dermatologico S. Gallicano (IFO) - UOC Dermatologia Infettiva
Roma, Italy, 00144
I.N.M.I. L. Spallanzani I.R.C.C.S. - .O.C. Malattie Infettive e Tropicali IV Divisione
Roma, Italy, 00149
I.N.M.I. L. Spallanzani I.R.C.C.S. - U.O.C. Infezioni Sistemiche e dell'Immunodepresso II Divisione
Roma, Italy, 00149
Università' degli studi di Roma La Sapienza - Dipartimento di Malattie Infettive e Tropicali
Roma, Italy, 00161
Università Cattolica del S. Cuore Policlinico Universitario A. Gemelli - Istituto di Clinica delle Malattie Infettive
Roma, Italy, 00168
Università degli studi di Sassari - Reparto Malattie Infettive
Sassari, Italy, 07100
Ospedale Amedeo di Savoia - Divisione A Malattie Infettive
Torino, Italy, 10149
Azienda ULSS 9 Treviso Ospedale S. Maria di Ca'Foncello - U.O. Malattie infettive
Treviso, Italy, 31100
Azienda Ospedaliera Universitaria Integrata di Verona - U.O.C. Malattie infettive
Verona, Italy, 37134 收起 <<
Belgium
... 展开 >> CHU Saint-Pierre University Hospital
Brussels, Belgium
University Hospital Gent
Ghent, Belgium
France
CHU - Groupe Saint-Andre
Bordeaux, France
CHU de Dijon
Dijon, France
Hopital Europeen Marseille
Marseille, France
C.H.U. de Nantes
Nantes, France
C.H.U. de NICE
Nice, France
Hopital Saint Louis
Paris cedex 10, France
Hopital Saint Antoine
Paris cedex 12, France
CHU Hotel Dieu
Paris, France
Hopital Necker les Enfants Malades
Paris, France
Hopital Haut-Leveque
Pessac, Cedex, France
Service des Maladies Infectieuses et du Voyageur
Tourcoing, France
Italy
Azienda Ospedaliera Papa Giovanni XXIII
Bergamo, Italy
Busto Arsizio Hospital
Busto Arsizio, Italy
IRCCS A.O.U. San Martino
Genova, Italy
Azienda Ospedaliera Luigi Sacco
Milano, Italy
Azienda Ospedaliero Universitaria Policlinico di Modena
Modena, Italy
U.O. Malattie Infettive
Pescara, Italy
Istituto Nazionale Malattie Infettive Lazzaro Spallanzani I.R.C.C.S.
Roma, Italy
Azienda Ospedaliero Universitaria di Sassari
Sassari, Italy
Dipartimento di Malattie Infettive e Tropicali
Torino, Italy
Spain
Hospital Clinic de Barcelona
Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Universitari Germans Trias i Pujol
Barcelona, Spain
Hospital Vall d'Hebron
Barcelona, Spain
Hospital 12 de Octubre
Madrid, Spain
Hospital General Universitario Gregorio Maranon
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Ramon Y Cajal University Hospital
Madrid, Spain
Hospital Costa Del Sol
Marbella, Spain
Hospital General Universitario de Valencia
Valencia, Spain
United Kingdom
Royal Victoria Hospital
Belfast, United Kingdom
Mortimer Market Centre
London, United Kingdom
Newcastle Royal Victoria Infirmary
Newcastle Upon Tyne, United Kingdom 收起 <<
Canada, British Columbia
... 展开 >>
Providence Health Care- St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Canada, Ontario
University Health Network - Toronto General Hospital Division
Toronto, Ontario, Canada, M5G2N2
Canada, Quebec
Montreal Chest Institute
Montreal, Quebec, Canada 收起 <<
France
... 展开 >> Hôpital Meynard
Fort-de-france, Martinique, France, 97261
Hôpital Avicenne
Bobigny, France, 93000
CHU Côte de Nacre
Caen, France, 14033
Centre Hospitalier Sud Francilien
Corbeil Essonnes, France, 91100
Hôpital Le Bocage
Dijon, France, 21079
Hôpital Raymond Poincaré
Garches, France, 92380
Hôpital Bicêtre
Kremlin Bicetre, France, 94275
Hôpital Gui de Chauliac
Montpellier, France, 34295
Hôpital Saint-Antoine
Paris, France, 75012
Hôpital Pitié-Salpêtrière
Paris, France, 75013
Hôpital Européen Georges Pompidou
Paris, France, 75015
Hôpital Necker
Paris, France, 75015
Hôpital Bichat
Paris, France, 75018
Hôpital Tenon
Paris, France, 75020
Hôpital Foch
Suresnes, France, 92151
Hôpital Purpan
Toulouse, France, 31059
Hôpital Bretonneau
Tours, France, 37044 收起 <<
Argentina
... 展开 >> Hospital Italiano de Buenos Aires
Buenos Aires, Ciudad de Buenos Aires, Argentina, C1181ACH
Hospital General de Agudos J M Ramos Mejia
Buenos Aires, Ciudad de Buenos Aires, Argentina, C1221ADC
Fundación IDEAA
Buenos Aires, Ciudad de Buenos Aires, Argentina, C1405CKC
Australia, New South Wales
St. Vincent's Hospital
Sydney, New South Wales, Australia, 2010
Australia, Queensland
Brisbane Sexual Health and HIV Service
Brisbane, Queensland, Australia, 4000
Canada, Alberta
Southern Alberta Clinic
Calgary, Alberta, Canada, T2R OX7
Canada, Ontario
University Health Network - Toronto General Hospital
Toronto, Ontario, Canada, M5G 2N2
Canada, Quebec
Clinic Opus/Lori
Montreal, Quebec, Canada, H3A 1T1
Germany
Klinikum der Universitat Zu Koln
Cologne, Germany, 50937
Universitätsklinikum Düsseldorf, Klinik für Gastroenterologie, Hepatologie und Infektiologie, MX-Ambulanz
Dusseldorf, Germany, 40225
Japan
Nagoya Medical Center
Nagoya, Japan, 460-0001
Mexico
Instituto Nacional de Ciencias Medicas y Nutriciòn Salvador Zubiran
Mexico City, Tlalpan DF, Mexico, 14000
Thailand
Chulalongkorn University Hospital
Bangkok, Thailand, 10330
United Kingdom
Western General Hospital
Edinburgh, Lothian, United Kingdom
Brighton & Sussex University NHS Trust
Brighton, Sussex, United Kingdom 收起 <<
United States, California
... 展开 >>
Beverly Hills, California, United States, 90211
San Diego, California, United States, 92093
San Francisco, California, United States, 94110
United States, Florida
Miami, Florida, United States, 33125
Orlando, Florida, United States, 32803
United States, Illinois
Chicago, Illinois, United States, 60612
United States, Maryland
Baltimore, Maryland, United States, 21287
United States, Massachusetts
Boston, Massachusetts, United States, 02114
United States, New York
New York, New York, United States, 10029
United States, Ohio
Cincinnati, Ohio, United States, 45267
United States, Texas
Dallas, Texas, United States, 75204
France
Paris, France
Germany
Bonn-Venusberg, Germany
Hamburg, Germany
Spain
Barcelona, Spain
Madrid, Spain 收起 <<
United States, California
... 展开 >>
Usc La Nichd Crs
Alhambra, California, United States, 91803
University of California, UC San Diego CRS
La Jolla, California, United States, 92093-0672
Miller Children's Hosp. Long Beach CA NICHD CRS
Long Beach, California, United States, 90806
Harbor UCLA Medical Ctr. NICHD CRS
Torrance, California, United States, 90502
United States, Connecticut
Connecticut Children's Med. Ctr.
Hartford, Connecticut, United States, 06106
United States, Florida
Pediatric Perinatal HIV Clinical Trials Unit CRS
Miami, Florida, United States, 33136
United States, Illinois
Rush Univ. Cook County Hosp. Chicago NICHD CRS
Chicago, Illinois, United States, 60612
Ann & Robert H. Lurie Children's Hospital of Chicago (LCH) CRS
Chicago, Illinois, United States, 60614-3393
United States, Maryland
Univ. of Maryland Baltimore NICHD CRS
Baltimore, Maryland, United States, 21201
Johns Hopkins Univ. Baltimore NICHD CRS
Baltimore, Maryland, United States, 21287
United States, Massachusetts
Children's Hosp. of Boston NICHD CRS
Boston, Massachusetts, United States, 02115
Baystate Health, Baystate Med. Ctr.
Springfield, Massachusetts, United States, 01199
WNE Maternal Pediatric Adolescent AIDS CRS
Worcester, Massachusetts, United States, 01605
United States, Michigan
Children's Hospital of Michigan NICHD CRS
Detroit, Michigan, United States, 48201
United States, New Jersey
Rutgers - New Jersey Medical School CRS
Newark, New Jersey, United States, 07103
United States, New York
Jacobi Med. Ctr. Bronx NICHD CRS
Bronx, New York, United States, 10461
SUNY Downstate Med. Ctr., Children's Hosp. at Downstate NICHD CRS
Brooklyn, New York, United States, 11203
Nyu Ny Nichd Crs
New York, New York, United States, 10016
United States, North Carolina
DUMC Ped. CRS
Durham, North Carolina, United States, 27710
United States, Tennessee
St. Jude Children's Research Hospital CRS
Memphis, Tennessee, United States, 38105-3678
United States, Washington
Seattle Children's Hospital CRS
Seattle, Washington, United States, 98105
Puerto Rico
University of Puerto Rico Pediatric HIV/AIDS Research Program CRS
San Juan, Puerto Rico, 00935
San Juan City Hosp. PR NICHD CRS
San Juan, Puerto Rico, 00936 收起 <<
Spain
... 展开 >> Germans Trias i Pujol Hospital
Badalona, Barcelona, Spain, 08916
Lluita contra la Sida Foundation, HIV Unit, Irsi Caixa Foundation
Badalona, Barcelona, Spain, 08916
Lluita contra la Sida Foundation, HIV Unit
Badalona, Barcelona, Spain, 08916 收起 <<
United States, Colorado
... 展开 >>
University of Colorado Denver
Aurora, Colorado, United States, 80045
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Tennessee
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Italy
Universita degli Studi di Pavia - Fondazione IRCCS Policlinico San Matteo
Pavia, Italy, 27100
South Africa
Be Part Yoluntu Centre
Cape Town, South Africa, 7646
Rahima Moosa Mother and Child Hopsital
Johannesburg, South Africa, 2112
Spain
Hospital Universitario De Getafe
Getafe, Madrid, Spain, 28095
Hospital 12 de Octubre
Madrid, Spain, 28041
Thailand
Thai Red Cross AIDS Research Centre (HIV-NAT)
Bangkok, Thailand, 10330
Siriraj Hospital
Bangkok, Thailand, 10700
Uganda
Joint Clinical Research Centre
Kampala, Uganda 收起 <<
France
... 展开 >> Unité des Maladies Infectieuses, CHU de CAEN
Caen, France, 14033
Service des Maladies Infectieuses, CHR Orléans La Source, ORLEANS CEDEX 2
CHR d'ORLEANS, France, 45067
Service d'Immunologie Clinique centre de Vaccination anti- VIH ANRS Hopital Henri- Mondor
Creteil, France, 94010
Service de Médecine Interne et Maladies Infectieuses, Groupe Hospitalier La Rochelle, Cedex 01
La Rochelle, France, 17019
Service de Pneumologie, centre Hospitalier Fontenoy, CH de CHARTRES
Le Coudray, France, 28630
CHU de NANCY
Nancy, France, 54035
Service des maladies Infectieuses et tropicales, CH GEORGES RENON
Niort, France, 79021
Service des Maladies Infectieuses et tropicales, APHP SAINT LOUIS
Paris, France, 75475
Hospital Tenon
Paris, France, 75970
Centre de diagnostic et thérapeutique, Hopital Hotel Dieu
Paris, France, 94010
Consultation Maladies Infectieuses, Chu de Poitiers, Cedex
Poitiers, France, 86021
Maladies Infectieuses, CHU de ROUEN
Rouen, France, 76031
Service de Médecine Interne, CH de SAINTONGE- BP 326
Saintes, France, 17108
Médecine Interne, Hôpital FOCH
Suresnes, France, 92151
Service Universitaire des Maladies Infectieuses et du Voyageur, CH DRON
Tourcoing, France, 59200
Service de Medecine Interne et Maladies Infectieuses, CHRU BRETONNEAU, TOURS CEDEX9
Tours, France, 37044 收起 <<
Argentina
... 展开 >> Hospital General de Agudos "Dr. José María Ramos Mejía"
Buenos Aires, Argentina, C1221ADC
Fundacion IDEAA
Buenos Aires, Argentina, C1405CKC
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
Australia, New South Wales
St. Vincent's Hospital
Sydney, New South Wales, Australia, 2010
Germany
Johann Wolfgang Goethe-University Hospital, Medical HIVCENTER
Frankfurt, Frankfurt am Main, Germany, 60590
Thailand
Chulalongkorn University Hospital
Bangkok, Thailand, 10330 收起 <<
United States, California
... 展开 >>
UCLA
Recruiting
Los Angeles, California, United States, 90095
United States, Colorado
Children's Hospital Colorado
Recruiting
Aurora, Colorado, United States
United States, Pennsylvania
St. Christopher's Hospital, for Children
Recruiting
Philadelphia, Pennsylvania, United States, 19134
United States, Tennessee
St. Judes Children's Research Hospital
Recruiting
Memphis, Tennessee, United States, 38105
United States, Washington
Seattle Children's Hospital
Recruiting
Seattle, Washington, United States
Panama
Hospital del Nino
Recruiting
Panama City, Panama
South Africa
Be Part Yoluntu Centre
Recruiting
Cape Town, South Africa
University of Stellenbosch
Recruiting
Cape Town, South Africa
Rahima Moosa Mother and Child Hopsital
Recruiting
Johannesburg, South Africa 收起 <<
United States, Alabama
... 展开 >>
Univ. of Alabama Birmingham NICHD CRS (5096)
Birmingham, Alabama, United States, 35294
United States, California
Miller Children's Hospital Long Beach (5093)
Long Beach, California, United States, 90806
Usc La Nichd Crs (5048)
Los Angeles, California, United States, 90033
UCLA-Los Angeles/Brazil AIDS Consortium (LABAC) CR (3601)
Los Angeles, California, United States, 90095
Univ of California, San Diego (UCSD) (4601)
San Diego, California, United States, 92103
United States, Colorado
Childrens Hospital (U. Colorado, Denver) NICHD CRS (5052)
Denver, Colorado, United States, 80218-1088
United States, District of Columbia
Children's National Med. Ctr. Washington DC NICHD CRS (5015)
Washington, District of Columbia, United States, 20010
United States, Florida
South Florida CDC Ft Lauderdale NICHD CRS (5055)
Ft Lauderdal, Florida, United States, 33316
Univ of Miami Pediatric/Perinatal HIV/AIDS (4201)
Miami, Florida, United States, 33136
United States, Illinois
Chicago Children's CRS (4001)
Chicago, Illinois, United States, 60611
Rush University Cook County Hospital NICHD CRS (5083)
Chicago, Illinois, United States, 60612
United States, Maryland
Johns Hopkins University NICHD CRS (5092)
Baltimore, Maryland, United States, 21287
United States, Massachusetts
Boston Medical Center Ped. HIV Program NICHD CRS (5011)
Boston, Massachusetts, United States, 02118
WNE Maternal Pediatric Adolescent AIDS CRS (7301)
Worcester, Massachusetts, United States, 01605
United States, Michigan
Wayne State University/Children's Hospital of Michigan NICHD CRS (5041)
Detroit, Michigan, United States, 48201
United States, New York
Jacobi Med. Ctr. Bronx NICHD CRS (5013)
Bronx, New York, United States, 10461
New York University NY (5012)
New York, New York, United States, 10016
Columbia IMPAACT Center (4101)
New York, New York, United States, 10032
SUNY Stony Brook (5040)
Stony Brook, New York, United States, 11794-8111
United States, Tennessee
St. Jude Childrens Research Hospital, Memphis (6501)
Memphis, Tennessee, United States, 38105-2794
United States, Texas
Texas Children's Hosp. CRS (3801)
Houston, Texas, United States, 77030
Puerto Rico
San Juan City Hosp. PR NICHD CRS (5031)
San Juan, Puerto Rico, 00927 收起 <<
United States, Massachusetts
... 展开 >>
Fenway Community Health Ctr. CRS
Boston, Massachusetts, United States, 02115
Botswana
Gaborone CRS
Gaborone, Botswana
Brazil
Hospital Geral de Nova Iguaçu CRS (HGNI CRS)
Nova Iguacu, Rio de Janeiro, Brazil, 26030-380
Hospital Nossa Senhora da Conceicao CRS
Port Alegre, Rio Grande do Sul, Brazil, 91350 200
HSE-Hospital dos Servidores do Estado CRS
Rio de Janeiro, Brazil, 20221-903
Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS
Rio de Janeiro, Brazil, 21040-360
India
NARI Clinic at Gadikhana Dr. Kotnis Municipal Dispensary CRS
Pune, Maharashtra, India, 411002
NARI Clinic at NIV CRS
Pune, Maharashtra, India, 411011
NARI Pune CRS
Pune, Maharashtra, India, 411026
Chennai Antiviral Research and Treatment (CART) CRS
Chennai, Tamil Nadu, India, 600113
Kenya
Kisumu Crs
Kisumu, Nyanza, Kenya, 40100
Malawi
Blantyre CRS
Blantyre, Malawi
Malawi CRS
Lilongwe, Malawi
South Africa
Soweto HPTN CRS
Johannesburg, Gauteng, South Africa, 2001
Wits Helen Joseph Hospital CRS (Wits HJH CRS)
Johannesburg, Gauteng, South Africa, 2092
Thailand
CMU HIV Prevention CRS
Chiang Mai, Thailand, 50202
Zimbabwe
Parirenyatwa CRS
Harare, Zimbabwe 收起 <<
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