Pectolinarigenin, a natural product isolated and purified from the herbs of Cirsium japonicum DC., possesses hepatoprotective and anti-inflammatory activity.
Pectolinarin/柳穿鱼叶苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Staphylococcus aureus
0.39 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
Streptococcus sobrinus
1.4 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
Streptococcus mutans
1.2 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
Escherichia coli
0.25 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
Enterococcus faecium
0.19 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
Enterococcus faecalis
0.39 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
T24 cells
0.01–50 μg/mL
24 hours
Reduced bacterial adherence
Antibiotics (Basel). 2022 Apr 29;11(5):598
Porphyromonas gingivalis
9.0 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
Cutibacterium acnes
12.5 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
Pseudomonas aeruginosa
0.9 μg/mL (IC50)
24 hours
Inhibited biofilm formation
Antibiotics (Basel). 2022 Apr 29;11(5):598
SARS-CoV 3CLpro
37.78 µM
16 hours
Inhibition of SARS-CoV 3CLpro enzymatic activity
J Enzyme Inhib Med Chem. 2020 Dec;35(1):145-151
L-929 fibroblasts
20 μg/mL
2 hours
Evaluate the antioxidant capacity of Pectolinarin, results showed that 20 μg/mL of Pectolinarin effectively counteracted the detrimental effects of reactive oxygen species (ROS).
J Cell Mol Med. 2024 Feb;28(4):e18130
SH-SY5Y neuronal cells
1, 2.5, 5, 10 µg/mL
24 hours
To investigate the protective effects of Pectolinarin against H2O2-induced oxidative stress. Results showed that Pectolinarin significantly increased cell viability and reduced ROS production and LDH release.
Molecules. 2023 Aug 2;28(15):5826
EA.hy926 endothelial cells
25, 50, 100, 200 μg/mL
24, 48, 72 hours
Assess the effect of Pectolinarin on endothelial cell proliferation, results showed that 50 μg/mL of Pectolinarin significantly promoted endothelial cell proliferation.
J Cell Mol Med. 2024 Feb;28(4):e18130
Pectolinarin/柳穿鱼叶苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 female mice
Ovariectomy model
Oral
20 mg/kg
Once daily for 8 weeks
To evaluate the protective effects of Pectolinarin on ovariectomy-induced osteoporosis, results showed Pectolinarin inhibited bone resorption and promoted bone formation.
Int J Mol Sci. 2023 Jan 13;24(2):1620
Mice
LPS-induced acute liver and kidney injury model
Intraperitoneal injection
25 mg/kg and 50 mg/kg
Once daily for 3 days
To evaluate the protective effect of Pectolinarin on LPS-induced acute liver and kidney injury. Results showed that Pectolinarin significantly alleviated histopathological injuries in liver and kidney and reduced serum TNF-α levels.
Molecules. 2022 Dec 8;27(24):8695
Sprague Dawley (SD) rats
Full-thickness skin defect model
Topical administration
50 μg/mL
Replenished every 3 days for 14 days
Evaluate the effect of Pectolinarin hydrogel on wound healing and scar formation, results showed that 50 μg/mL of Pectolinarin hydrogel significantly promoted wound healing and minimized scar formation.
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