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全部(267) Agonist(12) Antagonist(11) Inhibitor(3) Activator(2)
EP1-antagonist-1是一种 EP1 受体的拮抗剂,具有显著的抑制作用,pKi 为 7.54,pIC50 为 8.5,适用于疼痛和炎症相关的研究。
Carboprost tromethamine是前列腺素 F2α (prostaglandin F2α)的 15 甲基类似物,能够有效促进子宫规律性收缩,用于减少产后出血,适用于产科紧急情况下的应用。
p-Hydroxy-cinnamic acid is the isomer of cinnamic acid with anti-mutagenic and anti-tumor activities.
Ralinepag, is an orally available agonist of the prostacyclin (IP) receptor.
AM211 is a potent and selective prostaglandin D2 receptor type 2 antagonist with IC50 value of 4.9nM.
AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors.
E7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4. It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.
Asapiprant is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM.
MF-766是一种高效的 EP4 拮抗剂,能特异性地阻断 EP4 受体信号传导。它在癌症和炎症相关疾病研究中展现了良好的治疗潜力。
Limaprost is a PGE1 analog and potent platelet adhesion inhibitor.
Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist.
Taprenepag is an agonist of prostaglandin E2 receptor with EC50 of 2.8 nM with hypotensive activity.
Licarin A, a natural product isolated and purified from Machilus thunbergii, is a candidate compound for the treatment of immediate hypersensitivity via inhibition of rat mast cell line RBL-2H3 cells.
Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM).
Treprostinil sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB.
Alprostadil is an analog of prostaglandin which is prostaglandin E1 agonist with vasodilatory properties and can be used to treat erectile dysfunction.
BI-671800是一种前列腺素 D2 受体 (DP2/CRTH2) 拮抗剂,能够抑制过敏反应。它在哮喘和其他过敏性疾病研究中展现出良好的应用前景。
EP2 receptor antagonist-2 (CID891729)是一种EP2受体拮抗剂,能够抑制PGE2诱导的EP2受体激活,并且抑制N-甲基-D-天冬氨酸 (NMDA) 诱导的乳酸脱氢酶 (LDH) 释放。
Tags: 前列腺素受体 | Prostaglandin Receptor | G蛋白偶联受体/G蛋白 | GPCR/G Protein | 前列腺素受体 相关产品
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