There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator. Nigericin (0.1 µM) inhibits proliferation, migration, invasion and clonogenicity of H460 lung cancer cells[3]. A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM) and Fluo3 fluorescence (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM) and cytosolic pH (0.1-1 nM). Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance[4]. Nigericin could selectively target CSCs (Cancer stem cells) and sensitize CSCs in NPC (Nasopharyngeal carcinoma) to the widely used clinical drug cisplatin both in vitro and in vivo[5]. Nigericin exhibits great toxicity for the HT29 and SW116 cell line with IC50 of 12.92±0.25 μM and 15.86±0.18 μM. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions. HT29 cells treated with nigericin induced an increase in E-cadherin expression and a decrease in the vimentin expression relative to vehicle controls[6].
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